The Reds will play the Cardinals on Wednesday, September 17th, 2025. Your timezone's first pitch time is 1:15 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best Reds at Cardinals Odds
| Underdog St. Louis Cardinals | Favorite Cincinnati Reds |
|---|---|
| Over | Under |
|---|---|
| Underdog St. Louis Cardinals | Favorite Cincinnati Reds |
|---|---|
Matchup Odds FAQs
The Cincinnati Reds are the -120 moneyline favorite at BetMGM and the St. Louis Cardinals are the +100 moneyline underdog at BetMGM.
The best over line is 8.5 -110 runs at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 8.5 -110 runs at BetMGM, and that means you risk $110 to win $100 betting the under.
The Cincinnati Reds are -1.5 +145 run line favorites at BetMGM, while the St. Louis Cardinals are +1.5 -175 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Reds
Cardinals
1:15pm EDT | -120+100 |
- St. Louis Cardinals bettors risk $100 to win $100 at +100 odds. The implied probability for St. Louis Cardinals is 50%.
- Cincinnati Reds bettors risk $100 to win $83.33 at -120 odds. The implied probability for Cincinnati Reds is 54.55%.
Cincinnati Reds at St. Louis Cardinals Prop Bets
| BetMGM Bet |
|
|---|---|
Reds
Cardinals
First Team to Score
1:15pm EDT | -165+130Bet |
Reds
Cardinals
Tie
1st Inning Winner
1:15pm EDT | +270+310-130Bet |
Reds
Cardinals
Tie
First 3 Innings Winner
1:15pm EDT | +125+150+300Bet |
Reds
Cardinals
To Extra Innings
1:15pm EDT | Yes +775No -1400Bet |
| BetMGM | |
Reds
Cardinals
1st Team to Score Will Win
1:15pm EDT | Yes -250No +190Bet |
Reds
Total Runs
CIN at STL 1:15pm EDT | 4.5 o +1004.5 u -130Bet |
Cardinals
Total Runs
CIN at STL 1:15pm EDT | 3.5 o -1453.5 u +110Bet |
Andre Pallante
Strikeouts Thrown
CIN at STL 1:15pm EDT | 3.5 o -1253.5 u -105Bet |
| BetMGM | |
Brady Singer
Strikeouts Thrown
CIN at STL 1:15pm EDT | 4.5 o -1454.5 u +110Bet |
Cincinnati Reds & St. Louis Cardinals Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Cincinnati Reds World Series Odds|
Team | BetMGM |
|---|---|
| Reds | +20000 Bet |
|
Team | BetMGM |
|---|---|
| Cardinals | +100000 Bet |
Cincinnati Reds & St. Louis Cardinals Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cincinnati Reds | 75 | 75 | 0.500 | +16.0 | 40-34 | 35-41 | 676 | 651 | +25 | W1 | 5-5 |
| St. Louis Cardinals | 73 | 78 | 0.483 | +18.5 | 41-35 | 32-43 | 648 | 705 | -57 | L1 | 3-7 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Cincinnati Reds vs St. Louis Cardinals MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, September 17th, 2025 at 1:15 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Cincinnati Reds vs St. Louis Cardinals Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Cincinnati Reds vs St. Louis Cardinals Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 17, 2025 MLB Games
- Chicago Cubs vs Pittsburgh Pirates - 12:35pm EDT
- Baltimore Orioles vs Chicago White Sox - 2:10pm EDT
- San Francisco Giants vs Arizona Diamondbacks - 3:40pm EDT
- Atlanta Braves vs Washington Nationals - 4:05pm EDT
- Cleveland Guardians vs Detroit Tigers - 6:40pm EDT
- Oakland Athletics vs Boston Red Sox - 6:45pm EDT
- Toronto Blue Jays vs Tampa Bay Rays - 7:05pm EDT
- San Diego Padres vs New York Mets - 7:10pm EDT
- Seattle Mariners vs Kansas City Royals - 7:40pm EDT
- Los Angeles Angels vs Milwaukee Brewers - 7:40pm EDT
- New York Yankees vs Minnesota Twins - 7:40pm EDT
- Texas Rangers vs Houston Astros - 8:10pm EDT
- Miami Marlins vs Colorado Rockies - 8:40pm EDT
- Philadelphia Phillies vs Los Angeles Dodgers - 10:10pm EDT