The Astros will play the Athletics on Thursday, September 25th, 2025. Your timezone's first pitch time is 3:35 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best Astros at Athletics Odds
| Underdog Oakland Athletics | Favorite Houston Astros |
|---|---|
| Over | Under |
|---|---|
| Underdog Oakland Athletics | Favorite Houston Astros |
|---|---|
Matchup Odds FAQs
The Houston Astros are the -115 moneyline favorite at BetMGM and the Oakland Athletics are the -105 moneyline underdog at BetMGM.
The best over line is 9.5 -110 runs at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 9.5 -110 runs at BetMGM, and that means you risk $110 to win $100 betting the under.
The Houston Astros are -1.5 +140 run line favorites at BetMGM, while the Oakland Athletics are +1.5 -170 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Astros
Athletics
9/25/25 3:35pm EDT | -115-105 |
- Oakland Athletics bettors risk $100 to win $95.24 at -105 odds. The implied probability for Oakland Athletics is 51.22%.
- Houston Astros bettors risk $100 to win $86.96 at -115 odds. The implied probability for Houston Astros is 53.49%.
Houston Astros at Oakland Athletics Prop Bets
| BetMGM Bet |
|
|---|---|
Astros
Athletics
First Team to Score
9/25/25 3:35pm EDT | -165+130Bet |
Astros
Athletics
Tie
1st Inning Winner
9/25/25 3:35pm EDT | +260+275-115Bet |
Astros
Athletics
Tie
First 3 Innings Winner
9/25/25 3:35pm EDT | +130+135+333Bet |
Astros
Athletics
To Extra Innings
9/25/25 3:35pm EDT | Yes +825No -1400Bet |
| BetMGM | |
Astros
Athletics
1st Team to Score Will Win
9/25/25 3:35pm EDT | Yes -250No +190Bet |
Astros
Total Runs
HOU at OAK 9/25/25 3:35pm EDT | 4.5 o -1404.5 u +105Bet |
Framber Valdez
Strikeouts Thrown
HOU at OAK 9/25/25 3:35pm EDT | 4.5 o -1354.5 u +105Bet |
JT Ginn
Strikeouts Thrown
HOU at OAK 9/25/25 3:35pm EDT | 4.5 o -1404.5 u +105Bet |
Houston Astros & Oakland Athletics Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Houston Astros World Series Odds|
Team | BetMGM |
|---|---|
| Astros | +1300 Bet |
|
Team | BetMGM |
|---|---|
| Athletics | +10000 Bet |
Houston Astros & Oakland Athletics Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| e - Houston Astros | 87 | 75 | 0.537 | +10.0 | 46-35 | 41-40 | 686 | 665 | +21 | W2 | 4-6 |
| e - Oakland Athletics | 76 | 86 | 0.469 | +21.0 | 36-45 | 40-41 | 733 | 817 | -84 | L2 | 5-5 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Houston Astros vs Oakland Athletics MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Thursday, September 25th, 2025 at 3:35 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Houston Astros vs Oakland Athletics Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Houston Astros vs Oakland Athletics Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 25, 2025 MLB Games
- Tampa Bay Rays vs Baltimore Orioles
- Pittsburgh Pirates vs Cincinnati Reds
- Minnesota Twins vs Texas Rangers
- Los Angeles Dodgers vs Arizona Diamondbacks
- Miami Marlins vs Philadelphia Phillies
- Detroit Tigers vs Cleveland Guardians
- Chicago White Sox vs New York Yankees
- Boston Red Sox vs Toronto Blue Jays
- New York Mets vs Chicago Cubs
- Kansas City Royals vs Los Angeles Angels
- Colorado Rockies vs Seattle Mariners