USC vs Notre Dame Football Odds

The Trojans will play the Fighting Irish on Saturday, October 18th, 2025. The matchup takes place at Notre Dame Stadium. Watch this exciting Week 8 matchup at 7:30 pm EDT. Check local listings for coverage on NBC, Peacock.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.


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Table of Contents

Key Matchup Stats

We're now well into the 2025 college football season. Week 8 action features a matchup between USC and Notre Dame taking place at Notre Dame Stadium. The following are some key season stats to help you size up this game.

  • SportsBetting3.com Power Rankings - USC has a 97.67 conference power ranking for the 2025 season. The conference power ranking for Notre Dame is 99.67.
  • Away USC - Heading into Week 8, USC currently has a 1-1 record as an away team for the 2025 regular season. This ranks them 2nd in the Big Ten Conference for away team wins. Watch this stat carefully as the season progresses.
  • Home Notre Dame - Notre Dame has a 3-1 record as a home team. Looking ahead to this 2025 Week 8 matchup, they rank 1st in the Independent Conference for home team wins. Like the USC away record and ranking, you should continually keep tabs on this stat.
  • Points Scored - For the 2025 season, USC ranks 1st (273) in the Big Ten Conference, with Notre Dame currently ranking 1st (240) for points scored in the Independent Conference.
  • Points Against - Also in 2025, USC stands 7th (128) in the Big Ten Conference for points scored by opponents in 2025. Notre Dame sits at 4th (125) in the Independent Conference for points against in the 2025 season so far.
  • Team Records - USC has a 5-1 overall record for the 2025 regular season, with Notre Dame currently 4-2 for the 2025 NCAAF regular season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Paddy O'Parlay
Paddy O'Parlay

Get ready for a wild showdown between USC and Notre Dame on October 18th!

This Week 8 matchup will be held at the electric Notre Dame Stadium.

According to SportsBetting3.com Power Rankings, Notre Dame has a slight edge over USC.

USC enters the game with a 5-1 record, while Notre Dame stands at 4-2.

Don't miss out on the action - bet this game at BetRivers or BetMGM!

Review this game's prop bets and compare the odds below for an exciting Saturday matchup.

Best Trojans at Fighting Irish Odds


Best Point Spread Betting Odds
Underdog

USC
Favorite

Notre Dame
Notre Dame has a -10.5 -110 point spread at BetMGM OH. They are the point spread favorite in this matchup. USC has a +10.5 -110 point spread at BetMGM OH. USC is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 59.5 points. Risk $115 to win $100. BetMGM has the best under line of 59.5 points. Risk $105 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

USC
Favorite

Notre Dame
Notre Dame is the -400 moneyline favorite. Risk $400 to win $100 on Notre Dame at BetMGM. USC is the +310 underdog at BetMGM. Risk $100 to win $310 on USC. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the USC vs Notre Dame College Football game on Saturday, October 18th, 2025?

Notre Dame is a -10.5 -110 point spread favorite at BetMGM, while USC is a +10.5 -110 point spread underdog at BetMGM.

What is the over-under total line for the USC vs Notre Dame College Football game on Saturday, October 18th, 2025?

The best over line is 59.5 -115 points at BetMGM, which means you risk $115 to win $100 betting the over. The best under line is 59.5 -105 points at BetMGM, and that means you risk $105 to win $100 betting the under.

What is the moneyline for the USC vs Notre Dame College Football game on Saturday, October 18th, 2025?

Notre Dame is a -400 moneyline favorite at BetMGM and USC is a +310 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
USC
Notre Dame
10/18/25 7:30pm EDT
+10.5 -110-10.5 -110
Bet $100 at BetMGM Ohio
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Underdog USC - USC bettors risk $100 to win $90.91 at -110 odds.

A +10.5 USC underdog bet wins if they lose by 10 or fewer, tie, or win outright. Your bet loses if they lose by 11 or more.

Favorite Notre Dame - Notre Dame bettors risk $100 to win $90.91 at -110 odds.

A -10.5 Notre Dame favorite bet wins if they win by 11 or more. Your bet loses if they win by 10 or fewer, tie, or lose outright.

USC at Notre Dame Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
USC
Notre Dame
No Touchdown
To Score 1st Touchdown
10/18/25 7:30pm EDT
+154-225+10000Bet
USC
Notre Dame
Game to Overtime
10/18/25 7:30pm EDT
Yes +1200No -10000Bet
USC
Notre Dame
Both Teams Score 10+
10/18/25 7:30pm EDT
Yes -2000No +800Bet
USC
Notre Dame
Both Teams Score 20+
10/18/25 7:30pm EDT
Yes -210No +160Bet
BetMGM Sports Betting BetMGM
USC
Notre Dame
Both Teams Score 30+
10/18/25 7:30pm EDT
Yes +260No -350Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
WeekGameResultMargin
2025
Week 8
USC vs Notre Dame
Saturday, October 18th, 2025
ND 34, USC 24
Notre Dame Stadium
Notre Dame by 10
2024
Week 14
Notre Dame vs USC
Saturday, November 30th, 2024
ND 49, USC 35
Los Angeles Memorial Coliseum
Notre Dame by 14
2023
Week 7
USC vs Notre Dame
Saturday, October 14th, 2023
ND 48, USC 20
Notre Dame Stadium
Notre Dame by 28
2022
Week 13
Notre Dame vs USC
Saturday, November 26th, 2022
USC 38, ND 27
Los Angeles Memorial Coliseum
USC by 11
2021
Week 8
USC vs Notre Dame
Saturday, October 23rd, 2021
ND 31, USC 16
Notre Dame Stadium
Notre Dame by 15

Team Standings

2025-2026 College Football Regular Season Standings - USC, Notre Dame
Team Conf Conf% W L PF PA Home Away Strk
Independent
#12 Notre Dame0-00.000622991594-12-1W6
Big Ten
#23 USC4-10.800623181794-02-2W1

USC & Notre Dame Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

USC Championship Odds
2025-26 USC NCAA College Football Championship Odds

Team
BetMGM Sports Betting BetMGM
USC
+8000
Bet
Notre Dame Championship Odds
2025-26 Notre Dame NCAA College Football Championship Odds

Team
BetMGM Sports Betting BetMGM
Notre Dame
+1000
Bet

USC & Notre Dame Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results


2025-26 USC Games & Results
WeekMatchupDate & Result
Week 1Missouri State vs
USC
USC 73, MOST 13
Saturday, August 30th, 2025
Week 2Georgia Southern vs
USC
USC 59, GASO 20
Saturday, September 6th, 2025
Week 3USC vs
Purdue
USC 33, PUR 17
Saturday, September 13th, 2025
Week 4Michigan State vs
USC
USC 45, MSU 31
Saturday, September 20th, 2025
Week 5USC vs
Illinois
ILL 34, USC 32
Saturday, September 27th, 2025
Week 7Michigan vs
USC
USC 31, MICH 13
Saturday, October 11th, 2025
Week 8USC vs
Notre Dame
ND 34, USC 24
Saturday, October 18th, 2025
Week 10USC vs
Nebraska
Saturday, November 1st, 2025
7:30 pm EDT
Week 11Northwestern vs
USC
Friday, November 7th, 2025
9:00 pm EST
Week 12Iowa vs
USC
Saturday, November 15th, 2025
12:00 am EST
Week 13USC vs
Oregon
Saturday, November 22nd, 2025
12:00 am EST
Week 14UCLA vs
USC
Saturday, November 29th, 2025
12:00 am EST


2025-26 Notre Dame Games & Results
WeekMatchupDate & Result
Week 1Notre Dame vs
Miami (FL)
MIA 27, ND 24
Sunday, August 31st, 2025
Week 3Texas A&M vs
Notre Dame
TA&M 41, ND 40
Saturday, September 13th, 2025
Week 4Purdue vs
Notre Dame
ND 56, PUR 30
Saturday, September 20th, 2025
Week 5Notre Dame vs
Arkansas
ND 56, ARK 13
Saturday, September 27th, 2025
Week 6Boise State vs
Notre Dame
ND 28, BOIS 7
Saturday, October 4th, 2025
Week 7NC State vs
Notre Dame
ND 36, NCSU 7
Saturday, October 11th, 2025
Week 8USC vs
Notre Dame
ND 34, USC 24
Saturday, October 18th, 2025
Week 10Notre Dame vs
Boston College
Saturday, November 1st, 2025
12:00 am EDT
Week 11Navy vs
Notre Dame
Saturday, November 8th, 2025
7:30 pm EST
Week 12Notre Dame vs
Pittsburgh
Saturday, November 15th, 2025
12:00 am EST
Week 13Syracuse vs
Notre Dame
Saturday, November 22nd, 2025
3:30 pm EST
Week 14Notre Dame vs
Stanford
Saturday, November 29th, 2025
12:00 am EST

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the USC vs Notre Dame College Football Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Saturday, October 18th, 2025 at 7:30 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's College Football page, look for the USC vs Notre Dame Game.

    Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the USC vs Notre Dame Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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