The 49ers will play the Bills on Sunday, December 1st, 2024. The matchup takes place at Highmark Stadium. Watch this exciting Week 13 matchup at 8:20 pm EST. Check local listings for coverage on NBC, Peacock.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

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Matchup Stats
Captain Shady Lines
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Key Matchup Stats

It's now Week 13, as the 2024-25 NFL regular season is coming to a close. This week's action includes a matchup between the San Francisco 49ers and Buffalo Bills. They'll play on Sunday, December 1st, 2024 at Highmark Stadium, in a game that may affect this season's playoff picture. We've highlighted each team's key performance stats below. Take note of the following as you handicap this matchup.

SportsBetting3.com Power Rankings - Now Week 13 of the 2024-25 NFL regular season, the San Francisco 49ers have a 89.33 power ranking based on our formula. Their opponent, the Buffalo Bills, currently possess a 98.67 power ranking.
Away San Francisco 49ers - With the season coming to a close, the San Francisco 49ers have a 2-3-0 record as an away team, ranking them 5th in the league for away team wins.
Home Buffalo Bills - The Buffalo Bills come to this Week 13 game with a 5-0-0 record as a home team. They rank 1st in the league for home team wins as the 2024-25 regular season wraps up.
Points Scored - The San Francisco 49ers currently rank 14th (260) headed into Week 13, with the Buffalo Bills ranked 4th (320) for points scored to date.
Points Against - As the regular season winds down, the San Francisco 49ers rank 15th (260) for points score against them. Note that the Buffalo Bills now rank 23rd (214) for points scored against.
Team Records - The final games of the season will determine who heads to the playoffs. Heading into Week 13, the San Francisco 49ers have a 5-6-0 record, with the Buffalo Bills at 9-2-0 for the 2024-25 NFL regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Avast ye scallywags! The 49ers sail to Buffalo to plunder victory on Sunday!

Ye NFL regular season be near over, this match may change the playoff picture.

With a 5-6-0 record, the 49ers challenge the Bills who stand at 9-2-0.

This fierce battle be held at Highmark Stadium, where the Bills aim to defend their turf.

According to SportsBetting3.com, the Bills rank higher at 98.67 compared to the 49ers' 89.33.

Place a bet at BetRivers or BetMGM, and be sure to look at this matchup's prop bets below. We've compared odds from our partner sportsbooks.

Best 49ers at Bills Odds

**Best Point Spread Betting Odds**
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**Best Total Betting Odds**
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**Best Moneyline Betting Odds**
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NFL Odds Example

NFL Odds and Outcomes Explained
Game	Book

San Francisco 49ers at Buffalo Bills Prop Bets

NFL Prop Bets
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	Bet
49ers Bills 12/01/24 8:20pm EST	Pending

Recent Meetings Since 2020

Recent Meetings Since 2020
Week	Game	Result	Margin
2024 Week 13	49ers vs Bills Sunday, December 1st, 2024	BUF 35, SF 10 Highmark Stadium	Bills by 25
2020 Week 13	Bills vs 49ers Monday, December 7th, 2020	BUF 34, SF 24 State Farm Stadium	Bills by 10

Team Standings

2024-2025 NFL Regular Season Standings - San Francisco 49ers, Buffalo Bills
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xz - Buffalo Bills	13	4	0	0.765	525	368	8-0-0	5-4-0	5-1-0	0.833	9-3-0	0.750	1L	3-2-0
San Francisco 49ers	6	11	0	0.353	389	436	4-5-0	2-6-0	1-5-0	0.167	4-8-0	0.333	4L	1-4-0

San Francisco 49ers & Buffalo Bills Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds

No Super Bowl TM San Francisco 49ers YR: futures available

Buffalo Bills Futures Odds

No Super Bowl TM Buffalo Bills YR: futures available

San Francisco 49ers & Buffalo Bills Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco 49ers vs Buffalo Bills NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, December 1st, 2024 at 8:20 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Buffalo Bills Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Buffalo Bills Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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