The 49ers will play the Buccaneers on Sunday, October 12th, 2025. The matchup takes place at Raymond James Stadium. Watch this exciting Week 6 matchup at 4:25 pm EDT. Check local listings for coverage on CBS.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

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Matchup Stats
Captain Shady Lines
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Key Matchup Stats

The San Francisco 49ers and Tampa Bay Buccaneers will take the field at Raymond James Stadium for a key Week 6 matchup on Sunday, October 12th, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.

SportsBetting3.com Power Rankings - Heading into Week 6 of the 2025-26 season, the San Francisco 49ers have a power ranking of 95.67. Our calculations have the Tampa Bay Buccaneers at a 95.00 power ranking.
Away San Francisco 49ers - Now in the middle of the season, the San Francisco 49ers have a 3-0-0 record as an away team, ranking them 1st in the league for away team wins.
Home Tampa Bay Buccaneers - The Tampa Bay Buccaneers come to this Week 6 matchup with a 1-1-0 record as a home team. They rank 3rd in the league for home team wins so far this season.
Points Scored - The San Francisco 49ers currently rank 15th (106) on the edge of Week 6, with the Tampa Bay Buccaneers ranked 7th (135) for points scored to date.
Points Against - The San Francisco 49ers stand 20th (98) in the middle weeks of the regular season for points against. As for the Tampa Bay Buccaneers, they currently rank 9th (132) for points against.
Team Records - Standings become more important now more than ever. Approaching Week 6, the San Francisco 49ers have a 4-1-0 record, with the Tampa Bay Buccaneers at 4-1-0 for the 2025-26 regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Avast ye scallywags! The San Francisco 49ers be facing the Tampa Bay Buccaneers on Sunday!

Both teams be standin' at 4-1-0, makin' this a crucial Week 6 match!

The battle be happenin' at Raymond James Stadium, known for its lively city and culture.

Bet this game at BetMGM or our preferred sports betting partner BetRivers, look at this game's prop bets, and compare odds from partner sports betting sites.

Best 49ers at Buccaneers Odds

**Best Point Spread Betting Odds**
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Point Spread odds are updating, please check back soon.

**Best Total Betting Odds**
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**Best Moneyline Betting Odds**
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NFL Odds Example

NFL Odds and Outcomes Explained
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San Francisco 49ers at Tampa Bay Buccaneers Prop Bets

NFL Prop Bets
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	Bet
49ers Buccaneers 10/12/25 4:25pm EDT	Pending

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 6	49ers vs Buccaneers Sunday, October 12th, 2025	TB 30, SF 19 Raymond James Stadium	Buccaneers by 11
2024 Week 10	49ers vs Buccaneers Sunday, November 10th, 2024	SF 23, TB 20 Raymond James Stadium	49ers by 3
2023 Week 11	Buccaneers vs 49ers Sunday, November 19th, 2023	SF 27, TB 14 Levi's Stadium	49ers by 13
2022 Week 14	Buccaneers vs 49ers Sunday, December 11th, 2022	SF 35, TB 7 Levi's Stadium	49ers by 28

Team Standings

2025-2026 NFL Regular Season Standings - San Francisco 49ers, Tampa Bay Buccaneers
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xy - San Francisco 49ers	12	5	0	0.706	437	371	5-3-0	7-2-0	4-2-0	0.667	9-3-0	0.750	1L	4-1-0
Tampa Bay Buccaneers	8	9	0	0.471	380	411	4-4-0	4-5-0	3-3-0	0.500	6-6-0	0.500	1W	1-4-0

San Francisco 49ers & Tampa Bay Buccaneers Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds

No Super Bowl TM San Francisco 49ers YR: futures available

Tampa Bay Buccaneers Futures Odds

No Super Bowl TM Tampa Bay Buccaneers YR: futures available

San Francisco 49ers & Tampa Bay Buccaneers Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

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How to Bet on the San Francisco 49ers vs Tampa Bay Buccaneers NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, October 12th, 2025 at 4:25 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Tampa Bay Buccaneers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Tampa Bay Buccaneers Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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