San Francisco Giants vs San Diego Padres Odds

The Giants will play the Padres on Wednesday, April 30th, 2025. Your timezone's first pitch time is 4:10 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - The San Francisco Giants have a 97.33 power ranking. The power ranking for the San Diego Padres is 94.67.
  • Visiting San Francisco Giants - The San Francisco Giants have a 10-6 record as a visiting team, ranking them 1st Overall for visiting team wins.
  • Home San Diego Padres - The San Diego Padres have a 12-4 record as a home team. They rank 2nd for home team wins in the Overall standings.
  • Runs Scored - The San Francisco Giants currently stand 9th (135) Overall, with the San Diego Padres ranking 21st (106) for runs scored.
  • Runs Allowed - The San Francisco Giants are 20th (107) Overall for runs allowed. The San Diego Padres stand 25th (83) for runs allowed.
  • Team Streaks - The San Francisco Giants have won their last 2 games. Meanwhile, the San Diego Padres have lost their last 4 games.
  • Team Records - The San Francisco Giants have a 19-10 Overall record (0.0 GB National West Division), with the San Diego Padres possessing a 17-11 Overall standing (1.5 GB National West Division).

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast ye mateys! The Giants be facing the Padres in their home port...

San Francisco be comin' in hot with a 19-10 record, ready to plunder...

Ye best be visitin' SportsBetting3.com to bet on this game, review the odds below!

The Padres be strugglin' with a 3-7 record in their last 10 battles...

But don't be lettin' yer guard down, for they be a fierce opponent...

Only the strongest crew will emerge victorious in this epic clash on the high seas!

Best Giants at Padres Odds


Best Moneyline Betting Odds
Underdog

San Francisco Giants
Favorite

San Diego Padres
The San Diego Padres are the -135 moneyline favorite. Risk $135 to win $100 on the San Diego Padres at BetMGM. The San Francisco Giants are the +110 underdog at BetMGM. Risk $100 to win $110 on the San Francisco Giants. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 7 runs. Risk $120 to win $100. BetMGM has the best under line of 7 runs. Risk $100 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

San Francisco Giants
Favorite

San Diego Padres
The San Diego Padres have a -1.5 +170 run line at BetMGM OH. They are the run line favorite in this matchup. The San Francisco Giants have a +1.5 -210 run line at BetMGM OH. The San Francisco Giants are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the San Francisco Giants vs San Diego Padres MLB game on Wednesday, April 30th, 2025?

The San Diego Padres are the -135 moneyline favorite at BetMGM and the San Francisco Giants are the +110 moneyline underdog at BetMGM.

What is the over-under total line for the San Francisco Giants vs San Diego Padres MLB game on Wednesday, April 30th, 2025?

The best over line is 7 -120 runs at BetMGM, which means you risk $120 to win $100 betting the over. The best under line is 7 +100 runs at BetMGM, and that means you risk $100 to win $100 betting the under.

What is the run line for the San Francisco Giants vs San Diego Padres MLB game on Wednesday, April 30th, 2025?

The San Diego Padres are -1.5 +170 run line favorites at BetMGM, while the San Francisco Giants are +1.5 -210 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Giants
Padres
4:10pm EDT
+110-135
Bet $100 at BetMGM Ohio
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Possible Moneyline Outcomes
  • San Francisco Giants bettors risk $100 to win $110 at +110 odds. The implied probability for San Francisco Giants is 47.62%.
  • San Diego Padres bettors risk $100 to win $74.07 at -135 odds. The implied probability for San Diego Padres is 57.45%.

San Francisco Giants at San Diego Padres Prop Bets

MLB Prop Bets
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Bet
Giants
Padres
4:10pm EDT
Pending BetMGM

San Francisco Giants & San Diego Padres Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

San Francisco Giants World Series Odds
2025 San Francisco Giants World Series Odds

Team
BetMGM Sports Betting BetMGM
Giants
+4000
Bet
San Diego Padres World Series Odds
2025 San Diego Padres World Series Odds

Team
BetMGM Sports Betting BetMGM
Padres
+2000
Bet

San Francisco Giants & San Diego Padres Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - San Francisco Giants, San Diego Padres
Team W L Pct GB Home Away RS RA Diff Strk L10
San Francisco Giants19100.655+1.09-410-6135107+28W26-4
San Diego Padres17110.607+2.512-45-710683+23L43-7

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco Giants vs San Diego Padres MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, April 30th, 2025 at 4:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the San Francisco Giants vs San Diego Padres Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the San Francisco Giants vs San Diego Padres Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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