The Astros will play the Cardinals on Wednesday, April 16th, 2025. Your timezone's first pitch time is 12:15 pm CDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - The Houston Astros have a 90.67 power ranking. The power ranking for the St. Louis Cardinals is 93.67.
- Visiting Houston Astros - The Houston Astros have a 3-4 record as a visiting team, ranking them 6th Overall for visiting team wins.
- Home St. Louis Cardinals - The St. Louis Cardinals have a 7-3 record as a home team. They rank 3rd for home team wins in the Overall standings.
- Runs Scored - The Houston Astros currently stand 17th (63) Overall, with the St. Louis Cardinals ranking 3rd (90) for runs scored.
- Runs Allowed - The Houston Astros are 14th (66) Overall for runs allowed. The St. Louis Cardinals stand 5th (81) for runs allowed.
- Team Streaks - The Houston Astros lost their last game. Meanwhile, the St. Louis Cardinals have won their last 2 games.
- Team Records - The Houston Astros have a 7-9 Overall record (2.5 GB American West Division), with the St. Louis Cardinals possessing a 8-8 Overall standing (1.5 GB National Central Division).
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye mateys! The Astros be facing the Cardinals in their den...
Houston be strugglin' with a record below 0.500... (Arrr, it be shameful!)
But fear not, me hearties, for the Cardinals be only slightly better... (Aye, just barely!)
If ye be feelin' lucky, head to SportsBetting3.com... bet on this game... and review the odds below. May the best team prevail on the diamond!
Best Astros at Cardinals Odds
| Underdog St. Louis Cardinals | Favorite Houston Astros |
|---|---|
| Over | Under |
|---|---|
| Underdog St. Louis Cardinals | Favorite Houston Astros |
|---|---|
Matchup Odds FAQs
The Houston Astros are the -105 moneyline favorite at BetRivers and the St. Louis Cardinals are the -110 moneyline underdog at BetMGM.
The best over line is 8 -118 runs at BetMGM, which means you risk $118 to win $100 betting the over. The best under line is 8.5 -120 runs at BetRivers, and that means you risk $120 to win $100 betting the under.
The Houston Astros are -1.5 +160 run line favorites at BetRivers, while the St. Louis Cardinals are +1.5 -190 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Astros
Cardinals
4/16/25 12:15pm CDT | -110-110 |
- St. Louis Cardinals bettors risk $100 to win $90.91 at -110 odds. The implied probability for St. Louis Cardinals is 52.38%.
- Houston Astros bettors risk $100 to win $90.91 at -110 odds. The implied probability for Houston Astros is 52.38%.
Houston Astros at St. Louis Cardinals Prop Bets
| BetMGM Bet |
|
|---|---|
Astros
Cardinals
First Team to Score
4/16/25 12:15pm CDT | -155+120Bet |
Astros
Cardinals
Tie
1st Inning Winner
4/16/25 12:15pm CDT | +290+280-130Bet |
Astros
Cardinals
Tie
First 3 Innings Winner
4/16/25 12:15pm CDT | +140+135+300Bet |
Astros
Cardinals
To Extra Innings
4/16/25 12:15pm CDT | Yes +750No -1200Bet |
| BetMGM | |
Astros
Cardinals
1st Team to Score Will Win
4/16/25 12:15pm CDT | Yes -250No +190Bet |
Astros
Total Runs
HOU at STL 4/16/25 12:15pm CDT | 3.5 o -1453.5 u +110Bet |
Cardinals
Total Runs
HOU at STL 4/16/25 12:15pm CDT | 3.5 o -1403.5 u +105Bet |
Ronel Blanco
Strikeouts Thrown
HOU at STL 4/16/25 12:15pm CDT | 4.5 o -1404.5 u +105Bet |
Houston Astros & St. Louis Cardinals Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Houston Astros World Series Odds|
Team | BetMGM |
 BetRivers |
|---|---|---|
| Astros | +2200 Bet | +2000 Bet |
|
Team | BetMGM |
BetRivers |
|---|---|---|
| Cardinals | +15000 Bet | +10000 Bet |
Houston Astros & St. Louis Cardinals Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Houston Astros | 15 | 13 | 0.536 | +4.5 | 10-6 | 5-7 | 107 | 93 | +14 | W2 | 7-3 |
| St. Louis Cardinals | 12 | 17 | 0.414 | +8.0 | 10-5 | 2-12 | 131 | 135 | -4 | L2 | 3-7 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Houston Astros vs St. Louis Cardinals MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, April 16th, 2025 at 12:15 pm CDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Houston Astros vs St. Louis Cardinals Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Houston Astros vs St. Louis Cardinals Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other April 16, 2025 MLB Games
- Atlanta Braves vs Toronto Blue Jays - 4/16/25 12:07pm CDT
- Detroit Tigers vs Milwaukee Brewers - 4/16/25 12:10pm CDT
- New York Mets vs Minnesota Twins - 4/16/25 12:10pm CDT
- Chicago Cubs vs San Diego Padres - 4/16/25 3:10pm CDT
- Cleveland Guardians vs Baltimore Orioles - 4/16/25 5:35pm CDT
- Washington Nationals vs Pittsburgh Pirates - 4/16/25 5:40pm CDT
- Seattle Mariners vs Cincinnati Reds - 4/16/25 5:40pm CDT
- Arizona Diamondbacks vs Miami Marlins - 4/16/25 5:40pm CDT
- San Francisco Giants vs Philadelphia Phillies - 4/16/25 5:45pm CDT
- Kansas City Royals vs New York Yankees - 4/16/25 6:05pm CDT
- Boston Red Sox vs Tampa Bay Rays - 4/16/25 6:05pm CDT
- Oakland Athletics vs Chicago White Sox - 4/16/25 6:40pm CDT
- Los Angeles Angels vs Texas Rangers - 4/16/25 7:08pm CDT
- Colorado Rockies vs Los Angeles Dodgers - 4/16/25 9:10pm CDT