San Francisco Giants vs Los Angeles Dodgers Odds

The Giants will play the Dodgers on Sunday, September 21st, 2025. Your timezone's first pitch time is 4:10 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

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Best Giants at Dodgers Odds

**Best Moneyline Betting Odds**
Underdog San Francisco Giants	Favorite Los Angeles Dodgers
+175 BetMGM Bet	-210 BetMGM Bet

The Los Angeles Dodgers are the -210 moneyline favorite. Risk $210 to win $100 on the Los Angeles Dodgers at BetMGM. The San Francisco Giants are the +175 underdog at BetMGM. Risk $100 to win $175 on the San Francisco Giants. Learn more about how to bet on money lines.

**Best Total Betting Odds**
Over	Under
9 o -115 BetMGM Bet	9 u -105 BetMGM Bet

BetMGM has the best over line of 9 runs. Risk $115 to win $100. BetMGM has the best under line of 9 runs. Risk $105 to win $100. Our tutorial explains more about total bets.

**Best Run Line Betting Odds**
Underdog San Francisco Giants	Favorite Los Angeles Dodgers
+1.5 -115 BetMGM Bet	-1.5 -105 BetMGM Bet

The Los Angeles Dodgers have a -1.5 -105 run line at BetMGM OH. They are the run line favorite in this matchup. The San Francisco Giants have a +1.5 -115 run line at BetMGM OH. The San Francisco Giants are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the San Francisco Giants vs Los Angeles Dodgers MLB game on Sunday, September 21st, 2025?

The Los Angeles Dodgers are the -210 moneyline favorite at BetMGM and the San Francisco Giants are the +175 moneyline underdog at BetMGM.

What is the over-under total line for the San Francisco Giants vs Los Angeles Dodgers MLB game on Sunday, September 21st, 2025?

The best over line is 9 -115 runs at BetMGM, which means you risk $115 to win $100 betting the over. The best under line is 9 -105 runs at BetMGM, and that means you risk $105 to win $100 betting the under.

What is the run line for the San Francisco Giants vs Los Angeles Dodgers MLB game on Sunday, September 21st, 2025?

The Los Angeles Dodgers are -1.5 -105 run line favorites at BetMGM, while the San Francisco Giants are +1.5 -115 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained
Game	BetMGM Bet
Giants Dodgers 9/21/25 4:10pm EDT	+175 -210

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Possible Moneyline Outcomes

San Francisco Giants bettors risk $100 to win $175 at +175 odds. The implied probability for San Francisco Giants is 36.36%.
Los Angeles Dodgers bettors risk $100 to win $47.62 at -210 odds. The implied probability for Los Angeles Dodgers is 67.74%.

San Francisco Giants at Los Angeles Dodgers Prop Bets

MLB Prop Bets
+ Displays more odds
	BetMGM Bet
Giants Dodgers First Team to Score 9/21/25 4:10pm EDT	-118 -110 Bet
Giants Dodgers Tie 1st Inning Winner 9/21/25 4:10pm EDT	+333 +225 -118 Bet
Giants Dodgers Tie First 3 Innings Winner 9/21/25 4:10pm EDT	+185 +100 +320 Bet
Giants Dodgers To Extra Innings 9/21/25 4:10pm EDT	Yes +850 No -1600 Bet
	BetMGM
Giants Dodgers 1st Team to Score Will Win 9/21/25 4:10pm EDT	Yes -250 No +190 Bet
Dodgers Total Runs SFO at LAD 9/21/25 4:10pm EDT	4.5 o -150 4.5 u +115 Bet
Giants Total Runs SFO at LAD 9/21/25 4:10pm EDT	3.5 o -125 3.5 u -105 Bet
Emmet Sheehan Strikeouts Thrown SFO at LAD 9/21/25 4:10pm EDT	6.5 o +105 6.5 u -135 Bet

San Francisco Giants & Los Angeles Dodgers Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

San Francisco Giants World Series Odds

No World Series TM San Francisco Giants YR: futures available

Los Angeles Dodgers World Series Odds

2025 Los Angeles Dodgers World Series Odds
Team	BetMGM
Dodgers	-120 Bet

San Francisco Giants & Los Angeles Dodgers Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - San Francisco Giants, Los Angeles Dodgers
Team	W	L	Pct	GB	Home	Away	RS	RA	Diff	Strk	L10
x - Los Angeles Dodgers	93	69	0.574	+4.0	52-29	41-40	825	683	+142	W5	8-2
e - San Francisco Giants	81	81	0.500	+16.0	42-39	39-42	705	684	+21	W4	5-5

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco Giants vs Los Angeles Dodgers MLB Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 21st, 2025 at 4:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's MLB page, look for the San Francisco Giants vs Los Angeles Dodgers Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the San Francisco Giants vs Los Angeles Dodgers Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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