Chicago White Sox vs Chicago Cubs Odds

The White Sox will play the Cubs on Sunday, May 18th, 2025. Your timezone's first pitch time is 2:20 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - The Chicago White Sox have a 86.33 power ranking. The power ranking for the Chicago Cubs is 95.67.
  • Visiting Chicago White Sox - The Chicago White Sox have a 5-17 record as a visiting team, ranking them 10th Overall for visiting team wins.
  • Home Chicago Cubs - The Chicago Cubs have a 12-10 record as a home team. They rank 6th for home team wins in the Overall standings.
  • Runs Scored - The Chicago White Sox currently stand 25th (148) Overall, with the Chicago Cubs ranking 2nd (244) for runs scored.
  • Runs Allowed - The Chicago White Sox are 16th (177) Overall for runs allowed. The Chicago Cubs stand 9th (192) for runs allowed.
  • Team Streaks - The Chicago White Sox have won their last 3 games. Meanwhile, the Chicago Cubs lost their last game.
  • Team Records - The Chicago White Sox have a 14-29 Overall record (15.0 GB American Central Division), with the Chicago Cubs possessing a 25-19 Overall standing (0.0 GB National Central Division).

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast ye scallywags! The White Sox be settin' sail for enemy territory...to face the cursed Cubs on Sunday, May 18th, 2025.

With a dismal record of 14-29, the Sox be playin' like landlubbers...but don't count 'em out just yet, they be hungry for a win.

Ye best be headin' over to SportsBetting3.com to bet on this game...review the odds below, the outcome be as uncertain as a stormy sea.

The Cubs may be holdin' the advantage with a 25-19 record...but a 5-5 last 10 games performance from the White Sox be a warning sign.

Aye, the odds may be stacked against the Sox, but never underestimate...the heart of a true pirate - they may just surprise ye yet.

So hoist the Jolly Roger and prepare for a battle on the diamond...bet on this game at SportsBetting3.com, and may the best team win.

Best White Sox at Cubs Odds


Best Moneyline Betting Odds
Underdog

Chicago White Sox
Favorite

Chicago Cubs
The Chicago Cubs are the -278 moneyline favorite. Risk $278 to win $100 on the Chicago Cubs at BetRivers. The Chicago White Sox are the +240 underdog at BetMGM. Risk $100 to win $240 on the Chicago White Sox. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetRivers has the best over line of 7.5 runs. Risk $106 to win $100. BetMGM has the best under line of 7.5 runs. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

Chicago White Sox
Favorite

Chicago Cubs
The Chicago Cubs have a -1.5 -115 run line at BetRivers PA. They are the run line favorite in this matchup. The Chicago White Sox have a +1.5 +115 run line at BetMGM PA. The Chicago White Sox are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the Chicago White Sox vs Chicago Cubs MLB game on Sunday, May 18th, 2025?

The Chicago Cubs are the -278 moneyline favorite at BetRivers and the Chicago White Sox are the +240 moneyline underdog at BetMGM.

What is the over-under total line for the Chicago White Sox vs Chicago Cubs MLB game on Sunday, May 18th, 2025?

The best over line is 7.5 -106 runs at BetRivers, which means you risk $106 to win $100 betting the over. The best under line is 7.5 -110 runs at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the run line for the Chicago White Sox vs Chicago Cubs MLB game on Sunday, May 18th, 2025?

The Chicago Cubs are -1.5 -115 run line favorites at BetRivers, while the Chicago White Sox are +1.5 +115 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
White Sox
Cubs
5/18/25 2:20pm EDT
+240-295
Bet $100 at BetMGM Pennsylvania
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Possible Moneyline Outcomes
  • Chicago White Sox bettors risk $100 to win $240 at +240 odds. The implied probability for Chicago White Sox is 29.41%.
  • Chicago Cubs bettors risk $100 to win $33.9 at -295 odds. The implied probability for Chicago Cubs is 74.68%.

Chicago White Sox at Chicago Cubs Prop Bets

MLB Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
White Sox
Cubs
First Team to Score
5/18/25 2:20pm EDT
+110-140Bet
White Sox
Cubs
Tie
1st Inning Winner
5/18/25 2:20pm EDT
+425+230-145Bet
White Sox
Cubs
Tie
First 3 Innings Winner
5/18/25 2:20pm EDT
+250-115+270Bet
White Sox
Cubs
To Extra Innings
5/18/25 2:20pm EDT
Yes +825No -1400Bet
BetMGM Sports Betting BetMGM
White Sox
Cubs
1st Team to Score Will Win
5/18/25 2:20pm EDT
Yes -250No +190Bet
Cubs
Total Runs
CWS at CUB
5/18/25 2:20pm EDT
4.5 o -1254.5 u -105Bet
Colin Rea
Strikeouts Thrown
CWS at CUB
5/18/25 2:20pm EDT
5.5 o +1105.5 u -140Bet
Jonathan Cannon
Strikeouts Thrown
CWS at CUB
5/18/25 2:20pm EDT
4.5 o +1004.5 u -135Bet

Chicago White Sox & Chicago Cubs Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Chicago White Sox World Series Odds
2025 Chicago White Sox World Series Odds

Team
BetMGM Sports Betting BetMGM BetRivers Sports Betting BetRivers
White Sox
+100000
Bet
+50000
Bet
Chicago Cubs World Series Odds
2025 Chicago Cubs World Series Odds

Team
BetMGM Sports Betting BetMGM BetRivers Sports Betting BetRivers
Cubs
+1600
Bet
+1500
Bet

Chicago White Sox & Chicago Cubs Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - Chicago White Sox, Chicago Cubs
Team W L Pct GB Home Away RS RA Diff Strk L10
Chicago Cubs31210.596+2.515-1016-11310222+88L17-3
Chicago White Sox17350.327+16.512-145-21178227-49W24-6

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Chicago White Sox vs Chicago Cubs MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Sunday, May 18th, 2025 at 2:20 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the Chicago White Sox vs Chicago Cubs Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Chicago White Sox vs Chicago Cubs Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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