Chicago White Sox vs Cleveland Indians MLB Betting Lines

Odds Preview 3043

The White Sox will play the Indians on Sunday, September 26th, 2021 at 1:10 pm ET. Check network listings or your nearest streaming app for coverage. Our opening pitch flys at Eastern Standard, make sure you adjust for your local timezone.

Matchup Pitchers
  • White Sox - L. Giolito - R
  • Indians - T. Mckenzie - R

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

Best Money Line Bets
Underdog

Cleveland Indians
Favorite

Chicago White Sox
+146 Sb3gen1-158 Sb3gen1
+135 Sb3gen3-160 Sb3gen2
+134 Sb3gen2-160 Sb3gen3
Here are money lines for the outright winner. Favorite Chicago White Sox has a minus value. Lay $158 at Sb3gen1 to win $100. Underdog Cleveland Indians has a positive value. Risk $100 at Sb3gen1 to win $146.
Best Over and Under Total Lines
OverUnder
8o -125 Sb3gen18.5u -115 Sb3gen2
8.5o -105 Sb3gen28.5u -115 Sb3gen3
8.5o -105 Sb3gen38u +105 Sb3gen1
The over under line estimates the combined total of each team's final score. Sb3gen1 has the best over line of 8 points laying $125 to win $100. Sb3gen2 has the best under line of 8.5 u -115.
Best Underdog and Favorite Run Line Bets
Underdog

Cleveland Indians
Favorite

Chicago White Sox
+1.5 -115 Sb3gen3-1.5 +100 Sb3gen2
+1.5 -118 Sb3gen1-1.5 -102 Sb3gen1
+1.5 -120 Sb3gen2-1.5 -105 Sb3gen3
SportsBetting3.com has analyzed the latest lines. Review our "Best Run Line Bets" table above to smash the books this Sunday. Sb3gen2 has the best favorite Chicago White Sox run line at -1.5 points. Sb3gen3 has the best underdog Cleveland Indians run line at +1.5 points.

Review our point spread betting tutorial and video for more information.

MLB World Series Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament here. See past Championship results and learn how to bet World Series teasers, props and parlays.

Chicago White Sox World Series Odds
OutcomeSB3Gen SB3Gen
Chicago White Sox

Cached 2021-10-17 07:49:32
Cleveland Indians World Series Odds
OutcomeSB3Gen SB3Gen

Cached 2021-10-17 07:49:32

Team Standings

Season Standings
TeamWLPctGBHomeAwayStrkL10
Chicago White Sox93690.57414.093-6953-28L179-63
Cleveland Indians80820.49427.080-8240-41W171-71

Chicago White Sox Batting Stats

2021 Chicago White Sox Batting
Top 12 by Games Played
PlayerGPRHHRRBIBBSOAVG
Jose Abreu
1B
1528614830117611430.261
Yoan Moncada
3B
144741371461841570.263
Andrew Vaughn
RF
12756981548411010.235
Leury Garcia
LF
1266011155441970.267
Tim Anderson
SS
123941631761221190.309
Bo Bichette
SS
10583123197330940.291
Marcus Semien
SS
105791162566421040.275
Jonathan Schoop
2B
10559117186227900.285
Robbie Grossman
LF
10559871651721050.233
Vladimir Guerrero Jr.
DH
10482123348559750.322
Randal Grichuk
CF
1034597196816860.254
Jeimer Candelario
3B
1004710273648940.274

Cleveland Indians Batting Stats

2021 Cleveland Indians Batting
Top 12 by Games Played
PlayerGPRHHRRBIBBSOAVG
Jose Ramirez
3B
1521111473610372870.266
Amed Rosario
SS
141771551157311200.282
Franmil Reyes
RF
115571063085431490.254
Bo Bichette
SS
10583123197330940.291
Marcus Semien
SS
105791162566421040.275
Vladimir Guerrero Jr.
DH
10482123348559750.322
Randal Grichuk
CF
1034597196816860.254
Harold Ramirez
LF
99339174114560.268
Bradley Zimmer
CF
994468835301220.227
Cesar Hernandez
2B
966087184738900.231
Lourdes Gurriel Jr.
LF
933989114217730.264
Yu Chang
SS
89325493911690.228

Chicago White Sox Pitching Stats

2021 Chicago White Sox Pitching
Top 12 by Wins and Games Played
PlayerGPWLSVHLDIPKWHIPERA
Dylan Cease
SP
3213700165.22261.253.91
Carlos Rodon
SP
2413500132.21850.962.37
Lucas Giolito
SP
3111900178.22011.103.53
Lance Lynn
SP
2811600157.01761.072.69
Dallas Keuchel
SP
329900162.0951.535.28
Liam Hendriks
RP
698338071.01130.732.54
Aaron Bummer
RP
625522156.1751.263.51
Michael Kopech
SP
444301569.11031.133.50
Codi Dalton Heuer
SP
404101438.2391.425.12
Codi Heuer
RP
404101438.2391.425.12
Reynaldo Lopez
SP
20440057.2550.953.43
Garrett Crochet
RP
543501454.1651.272.82

Cleveland Indians Pitching Stats

2021 Cleveland Indians Pitching
Top 12 by Wins and Games Played
PlayerGPWLSVHLDIPKWHIPERA
Aaron Civale
SP
2112500124.1991.123.84
Zach Plesac
SP
2510600142.21001.204.67
Lance Lynn
SP
1910300108.21221.052.07
Cal Quantrill
SP
408301149.21211.182.89
Lucas Giolito
SP
228800129.01451.163.98
Dylan Cease
SP
228600114.21491.263.92
Carlos Rodon
SP
188500104.21490.962.49
James Karinchak
RP
6074111355.1781.214.07
Dallas Keuchel
SP
217400113.2711.354.51
Shane Bieber
SP
16740096.21341.213.17
Bryan Shaw
RP
816722077.1711.383.49
Liam Hendriks
RP
475226047.1750.722.47

More MLB Matchups

MatchupDate & Time
Kansas City Royals vs
Detroit Tigers
09/26/2021
12:10pm
Texas Rangers vs
Baltimore Orioles
09/26/2021
1:05pm
Washington Nationals vs
Cincinnati Reds
09/26/2021
1:10pm
Miami Marlins vs
Tampa Bay Rays
09/26/2021
1:10pm
Kansas City Royals vs
Detroit Tigers
09/26/2021
1:10pm
New York Mets vs
Milwaukee Brewers
09/26/2021
2:10pm
Toronto Blue Jays vs
Minnesota Twins
09/26/2021
2:10pm
St. Louis Cardinals vs
Chicago Cubs
09/26/2021
2:20pm
San Francisco Giants vs
Colorado Rockies
09/26/2021
3:10pm
Seattle Mariners vs
Los Angeles Angels
09/26/2021
4:07pm
Houston Astros vs
Oakland Athletics
09/26/2021
4:07pm
Los Angeles Dodgers vs
Arizona Diamondbacks
09/26/2021
4:10pm
Atlanta Braves vs
San Diego Padres
09/26/2021
4:10pm
New York Yankees vs
Boston Red Sox
09/26/2021
7:08pm