The White Sox will play the Yankees on Thursday, September 25th, 2025. Your timezone's first pitch time is 7:05 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best White Sox at Yankees Odds
| Underdog Chicago White Sox | Favorite New York Yankees |
|---|---|
| Over | Under |
|---|---|
| Underdog Chicago White Sox | Favorite New York Yankees |
|---|---|
Matchup Odds FAQs
The New York Yankees are the -295 moneyline favorite at BetMGM and the Chicago White Sox are the +240 moneyline underdog at BetMGM.
The best over line is 8.5 -115 runs at BetMGM, which means you risk $115 to win $100 betting the over. The best under line is 8.5 -105 runs at BetMGM, and that means you risk $105 to win $100 betting the under.
The New York Yankees are -2.5 +110 run line favorites at BetMGM, while the Chicago White Sox are +2.5 -135 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
White Sox
Yankees
9/25/25 7:05pm EDT | +240-295 |
- Chicago White Sox bettors risk $100 to win $240 at +240 odds. The implied probability for Chicago White Sox is 29.41%.
- New York Yankees bettors risk $100 to win $33.9 at -295 odds. The implied probability for New York Yankees is 74.68%.
Chicago White Sox at New York Yankees Prop Bets
| BetMGM Bet |
|
|---|---|
White Sox
Yankees
First Team to Score
9/25/25 7:05pm EDT | +120-155Bet |
White Sox
Yankees
Tie
1st Inning Winner
9/25/25 7:05pm EDT | +450+190-125Bet |
White Sox
Yankees
Tie
First 3 Innings Winner
9/25/25 7:05pm EDT | +280-140+320Bet |
White Sox
Yankees
To Extra Innings
9/25/25 7:05pm EDT | Yes +875No -1600Bet |
| BetMGM | |
White Sox
Yankees
1st Team to Score Will Win
9/25/25 7:05pm EDT | Yes -250No +190Bet |
Yankees
Total Runs
CWS at NYY 9/25/25 7:05pm EDT | 5.5 o +1055.5 u -140Bet |
Carlos Rodon
Strikeouts Thrown
CWS at NYY 9/25/25 7:05pm EDT | 6.5 o +1156.5 u -155Bet |
Davis Martin
Strikeouts Thrown
CWS at NYY 9/25/25 7:05pm EDT | 4.5 o +1104.5 u -145Bet |
Chicago White Sox & New York Yankees Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Chicago White Sox World Series OddsNo World Series TM Chicago White Sox YR: futures available
New York Yankees World Series OddsNo World Series TM New York Yankees YR: futures available
Chicago White Sox & New York Yankees Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| y - New York Yankees | 94 | 68 | 0.580 | +3.0 | 50-31 | 44-37 | 849 | 685 | +164 | W8 | 9-1 |
| e - Chicago White Sox | 60 | 102 | 0.370 | +37.0 | 33-48 | 27-54 | 647 | 742 | -95 | W1 | 3-7 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Chicago White Sox vs New York Yankees MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Thursday, September 25th, 2025 at 7:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Chicago White Sox vs New York Yankees Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Chicago White Sox vs New York Yankees Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 25, 2025 MLB Games
- Tampa Bay Rays vs Baltimore Orioles - 9/25/25 1:06pm EDT
- Pittsburgh Pirates vs Cincinnati Reds - 9/25/25 2:00pm EDT
- Minnesota Twins vs Texas Rangers - 9/25/25 2:35pm EDT
- Houston Astros vs Oakland Athletics - 9/25/25 3:35pm EDT
- Los Angeles Dodgers vs Arizona Diamondbacks - 9/25/25 3:40pm EDT
- Miami Marlins vs Philadelphia Phillies - 9/25/25 6:05pm EDT
- Detroit Tigers vs Cleveland Guardians - 9/25/25 6:40pm EDT
- Boston Red Sox vs Toronto Blue Jays - 9/25/25 7:07pm EDT
- New York Mets vs Chicago Cubs - 9/25/25 7:40pm EDT
- Kansas City Royals vs Los Angeles Angels - 9/25/25 9:38pm EDT
- Colorado Rockies vs Seattle Mariners - 9/25/25 9:40pm EDT