The Astros will play the White Sox on Sunday, May 4th, 2025. Your timezone's first pitch time is 2:10 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - The Houston Astros have a 92.67 power ranking. The power ranking for the Chicago White Sox is 86.00.
- Visiting Houston Astros - The Houston Astros have a 6-8 record as a visiting team, ranking them 6th Overall for visiting team wins.
- Home Chicago White Sox - The Chicago White Sox have a 6-11 record as a home team. They rank 10th for home team wins in the Overall standings.
- Runs Scored - The Houston Astros currently stand 15th (128) Overall, with the Chicago White Sox ranking 19th (119) for runs scored.
- Runs Allowed - The Houston Astros are 23rd (114) Overall for runs allowed. The Chicago White Sox stand 14th (144) for runs allowed.
- Team Streaks - The Houston Astros won their last game. Meanwhile, the Chicago White Sox lost their last game.
- Team Records - The Houston Astros have a 17-15 Overall record (3.0 GB American West Division), with the Chicago White Sox possessing a 9-24 Overall standing (11.5 GB American Central Division).
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scallywags! The Astros be heading to Chicago to plunder the White Sox...
Houston be lookin' to add to their winnin' ways against the hapless White Sox...
Ye best be visitin' SportsBetting3.com to bet on this game, review the odds below!
Best Astros at White Sox Odds
| Underdog Chicago White Sox | Favorite Houston Astros |
|---|---|
| Over | Under |
|---|---|
| Underdog Chicago White Sox | Favorite Houston Astros |
|---|---|
Matchup Odds FAQs
The Houston Astros are the -180 moneyline favorite at BetMGM and the Chicago White Sox are the +145 moneyline underdog at BetMGM.
The best over line is 8.5 -105 runs at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 8.5 -115 runs at BetMGM, and that means you risk $115 to win $100 betting the under.
The Houston Astros are -1.5 -110 run line favorites at BetMGM, while the Chicago White Sox are +1.5 -110 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Astros
White Sox
5/04/25 2:10pm EDT | -180+145 |
- Chicago White Sox bettors risk $100 to win $145 at +145 odds. The implied probability for Chicago White Sox is 40.82%.
- Houston Astros bettors risk $100 to win $55.56 at -180 odds. The implied probability for Houston Astros is 64.29%.
Houston Astros at Chicago White Sox Prop Bets
| BetMGM Bet |
|
|---|---|
Astros
White Sox
First Team to Score
5/04/25 2:10pm EDT | -200+155Bet |
Astros
White Sox
Tie
1st Inning Winner
5/04/25 2:10pm EDT | +250+375-140Bet |
Astros
White Sox
Tie
First 3 Innings Winner
5/04/25 2:10pm EDT | +110+195+270Bet |
Astros
White Sox
To Extra Innings
5/04/25 2:10pm EDT | Yes +775No -1400Bet |
| BetMGM | |
Astros
White Sox
1st Team to Score Will Win
5/04/25 2:10pm EDT | Yes -250No +190Bet |
Astros
Total Runs
HOU at CWS 5/04/25 2:10pm EDT | 4.5 o -1254.5 u -105Bet |
Bryse Wilson
Strikeouts Thrown
HOU at CWS 5/04/25 2:10pm EDT | 2.5 o -1052.5 u -125Bet |
Houston Astros & Chicago White Sox Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Houston Astros World Series Odds|
Team | BetMGM |
|---|---|
| Astros | +1000 Bet |
|
Team | BetMGM |
|---|---|
| White Sox | +200000 Bet |
Houston Astros & Chicago White Sox Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Houston Astros | 56 | 40 | 0.583 | +2.5 | 33-19 | 23-21 | 418 | 362 | +56 | L1 | 4-6 |
| Chicago White Sox | 32 | 65 | 0.330 | +27.0 | 21-29 | 11-36 | 332 | 430 | -98 | L2 | 4-6 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Houston Astros vs Chicago White Sox MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, May 4th, 2025 at 2:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Houston Astros vs Chicago White Sox Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Houston Astros vs Chicago White Sox Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other May 4, 2025 MLB Games
- New York Mets vs St. Louis Cardinals
- Tampa Bay Rays vs New York Yankees
- Kansas City Royals vs Baltimore Orioles
- Minnesota Twins vs Boston Red Sox
- San Diego Padres vs Pittsburgh Pirates
- Cleveland Guardians vs Toronto Blue Jays
- Oakland Athletics vs Miami Marlins
- Arizona Diamondbacks vs Philadelphia Phillies
- Chicago Cubs vs Milwaukee Brewers
- Seattle Mariners vs Texas Rangers
- Colorado Rockies vs San Francisco Giants
- Detroit Tigers vs Los Angeles Angels
- Washington Nationals vs Cincinnati Reds
- New York Mets vs St. Louis Cardinals
- Los Angeles Dodgers vs Atlanta Braves