The Guardians will play the Red Sox on Wednesday, September 3rd, 2025. Your timezone's first pitch time is 6:45 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best Guardians at Red Sox Odds
| Underdog Cleveland Guardians | Favorite Boston Red Sox |
|---|---|
| Over | Under |
|---|---|
| Underdog Cleveland Guardians | Favorite Boston Red Sox |
|---|---|
Matchup Odds FAQs
The Boston Red Sox are the -150 moneyline favorite at BetMGM and the Cleveland Guardians are the +125 moneyline underdog at BetMGM.
The best over line is 9 -115 runs at BetMGM, which means you risk $115 to win $100 betting the over. The best under line is 9 -105 runs at BetMGM, and that means you risk $105 to win $100 betting the under.
The Boston Red Sox are -1.5 +135 run line favorites at BetMGM, while the Cleveland Guardians are +1.5 -160 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Guardians
Red Sox
9/03/25 6:45pm EDT | +125-150 |
- Cleveland Guardians bettors risk $100 to win $125 at +125 odds. The implied probability for Cleveland Guardians is 44.44%.
- Boston Red Sox bettors risk $100 to win $66.67 at -150 odds. The implied probability for Boston Red Sox is 60%.
Cleveland Guardians at Boston Red Sox Prop Bets
| BetMGM Bet |
|
|---|---|
Guardians
Red Sox
First Team to Score
9/03/25 6:45pm EDT | -140+110Bet |
Guardians
Red Sox
Tie
1st Inning Winner
9/03/25 6:45pm EDT | +300+250-120Bet |
Guardians
Red Sox
Tie
First 3 Innings Winner
9/03/25 6:45pm EDT | +154+120+320Bet |
Guardians
Red Sox
To Extra Innings
9/03/25 6:45pm EDT | Yes +800No -1400Bet |
| BetMGM | |
Guardians
Red Sox
1st Team to Score Will Win
9/03/25 6:45pm EDT | Yes -250No +190Bet |
Red Sox
Total Runs
CLE at BOS 9/03/25 6:45pm EDT | 4.5 o -1254.5 u -105Bet |
Guardians
Total Runs
CLE at BOS 9/03/25 6:45pm EDT | 3.5 o -1503.5 u +115Bet |
Joey Cantillo
Strikeouts Thrown
CLE at BOS 9/03/25 6:45pm EDT | 4.5 o -1554.5 u +120Bet |
Cleveland Guardians & Boston Red Sox Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Cleveland Guardians World Series Odds|
Team | BetMGM |
|---|---|
| Guardians | +10000 Bet |
|
Team | BetMGM |
|---|---|
| Red Sox | +2000 Bet |
Cleveland Guardians & Boston Red Sox Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Boston Red Sox | 82 | 69 | 0.543 | +10.0 | 45-31 | 37-38 | 737 | 634 | +103 | L1 | 4-6 |
| Cleveland Guardians | 79 | 71 | 0.527 | +12.5 | 41-34 | 38-37 | 587 | 616 | -29 | W5 | 9-1 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Cleveland Guardians vs Boston Red Sox MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, September 3rd, 2025 at 6:45 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Cleveland Guardians vs Boston Red Sox Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Cleveland Guardians vs Boston Red Sox Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 3, 2025 MLB Games
- Miami Marlins vs Washington Nationals - 9/03/25 1:05pm EDT
- New York Mets vs Detroit Tigers - 9/03/25 1:10pm EDT
- Texas Rangers vs Arizona Diamondbacks - 9/03/25 3:40pm EDT
- Baltimore Orioles vs San Diego Padres - 9/03/25 4:10pm EDT
- Los Angeles Dodgers vs Pittsburgh Pirates - 9/03/25 6:40pm EDT
- Toronto Blue Jays vs Cincinnati Reds - 9/03/25 6:40pm EDT
- Seattle Mariners vs Tampa Bay Rays - 9/03/25 7:35pm EDT
- Philadelphia Phillies vs Milwaukee Brewers - 9/03/25 7:40pm EDT
- Chicago White Sox vs Minnesota Twins - 9/03/25 7:40pm EDT
- Atlanta Braves vs Chicago Cubs - 9/03/25 7:40pm EDT
- Los Angeles Angels vs Kansas City Royals - 9/03/25 7:40pm EDT
- Oakland Athletics vs St. Louis Cardinals - 9/03/25 7:45pm EDT
- New York Yankees vs Houston Astros - 9/03/25 8:10pm EDT
- San Francisco Giants vs Colorado Rockies - 9/03/25 8:40pm EDT