Cleveland Guardians vs Boston Red Sox Odds

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The Guardians will play the Red Sox on Tuesday, September 22nd, 2026. Your timezone's first pitch time is 6:45 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Best Guardians at Red Sox Odds


Best Moneyline Betting Odds
TBDTBD
Moneyline odds are updating, please check back soon.

Best Total Betting Odds
OverUnder
Total odds are updating, please check back soon.

Best Run Line Betting Odds
TBDTBD
Run Line odds are updating, please check back soon.

MLB Odds Example

MLB Odds and Outcomes Explained
Game Book

Cleveland Guardians at Boston Red Sox Prop Bets

MLB Prop Bets
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Guardians
Red Sox
6:45pm EDT
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Cleveland Guardians & Boston Red Sox Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Cleveland Guardians World Series Odds

No World Series TM Cleveland Guardians YR: futures available

Boston Red Sox World Series Odds

No World Series TM Boston Red Sox YR: futures available

Cleveland Guardians & Boston Red Sox Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2026 MLB Regular Season Standings - Cleveland Guardians, Boston Red Sox
Team W L Pct GB Home Away RS RA Diff Strk L10
z - Boston Red Sox84720.538+14.038-3746-35678598+80L24-6
Cleveland Guardians81750.519+17.041-4040-35649647+2W57-3

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Cleveland Guardians vs Boston Red Sox MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Tuesday, September 22nd, 2026 at 6:45 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the Cleveland Guardians vs Boston Red Sox Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Cleveland Guardians vs Boston Red Sox Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other September 22, 2026 MLB Games

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