The Indians will play the Astros on Wednesday, July 21st, 2021. Your timezone's first pitch time is 8:10 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

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Best Indians at Astros Odds

**Best Moneyline Betting Odds**
TBD	TBD

Moneyline odds are updating, please check back soon.

**Best Total Betting Odds**
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**Best Run Line Betting Odds**
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Game	Book

Cleveland Indians at Houston Astros Prop Bets

MLB Prop Bets
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	BetMGM Bet
Indians Astros 7/21/21 8:10pm EDT	Pending BetMGM

Cleveland Indians & Houston Astros Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Cleveland Indians World Series Odds

No World Series TM Cleveland Indians YR: futures available

Houston Astros World Series Odds

2025 Houston Astros World Series Odds
Team	BetMGM
Astros	+1100 Bet

Cleveland Indians & Houston Astros Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2021 MLB Regular Season Standings - Cleveland Indians, Houston Astros
Team	W	L	Pct	GB	Home	Away	RS	RA	Diff	Strk	L10
x - Houston Astros	95	67	0.586	+12.0	51-30	44-37	863	658	+205	W2	4-6
e - Cleveland Indians	80	82	0.494	+27.0	40-41	40-41	717	727	-10	W1	5-5

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Cleveland Indians vs Houston Astros MLB Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, July 21st, 2021 at 8:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's MLB page, look for the Cleveland Indians vs Houston Astros Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Cleveland Indians vs Houston Astros Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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Cleveland Indians vs Houston Astros Odds

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