Cleveland Indians vs Houston Astros MLB Betting Lines

Odds Preview 2123

The Indians will play the Astros on Wednesday, July 21st, 2021 at 8:10 pm ET. Check network listings or your nearest streaming app for coverage. Our opening pitch flys at Eastern Standard, make sure you adjust for your local timezone.

Matchup Pitchers
  • Indians - E. Morgan - R
  • Astros - L. Mccullers Jr - R

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

Best Money Line Bets
Underdog
Cleveland Indians
Cleveland Indians
Favorite
Houston Astros
Houston Astros
+220 Sb3gen1 -235 Sb3gen3
+220 Sb3gen2 -245 Sb3gen1
+190 Sb3gen3 -260 Sb3gen2
Here are money lines for the outright winner. Favorite Houston Astros has a minus value. Lay $235 at Sb3gen3 to win $100. Underdog Cleveland Indians has a positive value. Risk $100 at Sb3gen1 to win $220.
Best Over and Under Total Lines
OverUnder
8.5o -105 Sb3gen1 8.5u -105 Sb3gen3
8.5o -105 Sb3gen2 8.5u -115 Sb3gen1
8.5o -115 Sb3gen3 8.5u -115 Sb3gen2
The over under line estimates the combined total of each team's final score. Sb3gen1 has the best over line of 8.5 points laying $105 to win $100. Sb3gen3 has the best under line of 8.5 u -105.
Best Underdog and Favorite Run Line Bets
Underdog
Cleveland Indians
Cleveland Indians
Favorite
Houston Astros
Houston Astros
+1.5 +115 Sb3gen2 -1.5 -125 Sb3gen3
+1.5 +113 Sb3gen1 -1.5 -133 Sb3gen1
+1.5 +105 Sb3gen3 -1.5 -135 Sb3gen2
SportsBetting3.com has analyzed the latest lines. Review our "Best Run Line Bets" table above to smash the books this Wednesday. Sb3gen3 has the best favorite Houston Astros run line at -1.5 points. Sb3gen2 has the best underdog Cleveland Indians run line at +1.5 points.

Review our point spread betting tutorial and video for more information.

MLB World Series Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament here. See past Championship results and learn how to bet World Series teasers, props and parlays.

Cleveland Indians World Series Odds
OutcomeSB3Gen SB3Gen
Cleveland IndiansCleveland Indians

Cached 2021-07-26 21:15:00
Houston Astros World Series Odds
OutcomeSB3Gen SB3Gen
Houston AstrosHouston Astros

Cached 2021-07-26 21:15:00

Team Standings

Season Standings
Team W L Pct GB Home Away Strk L10
Houston AstrosCleveland Indians 48 47 0.505 12.0 24-21 24-26 L2 5-5
Houston AstrosHouston Astros 59 39 0.602 2.5 32-20 27-19 W1 5-5

Cleveland Indians Batting Stats

2021 Cleveland Indians Batting
Top 12 by Games Played
Player GP R H HR RBI BB SO AVG
Cesar Hernandez
2B
91 55 81 16 43 36 89 0.226
Jose Ramirez
3B
87 63 78 19 52 38 47 0.252
Amed Rosario
SS
87 42 85 5 27 19 72 0.262
Eddie Rosario
LF
78 29 72 7 46 17 47 0.254
Josh Naylor
LF
69 28 59 7 21 14 45 0.253
Harold Ramirez
LF
62 25 57 6 24 10 32 0.279
Franmil Reyes
RF
54 30 53 17 45 15 70 0.264
Yu Chang
SS
50 13 20 2 14 5 33 0.179
Austin Hedges
C
47 12 23 4 14 8 51 0.159
James Karinchak
RP
44 0 0 0 0 0 0 0.000
Jake Bauers
1B
43 7 19 2 6 12 27 0.190
Bryan Shaw
RP
43 0 0 0 0 0 0 0.000

Houston Astros Batting Stats

2021 Houston Astros Batting
Top 12 by Games Played
Player GP R H HR RBI BB SO AVG
Myles Straw
CF
93 41 81 2 31 38 66 0.263
Yuli Gurriel
1B
91 47 104 10 59 38 40 0.313
Carlos Correa
SS
89 63 89 16 53 48 75 0.269
Kyle Tucker
LF
86 52 88 18 57 27 57 0.276
Jose Altuve
2B
85 72 96 23 59 44 61 0.277
Yordan Alvarez
DH
82 55 87 17 61 25 95 0.282
Michael Brantley
LF
76 48 101 6 35 19 35 0.330
Martin Maldonado
C
70 25 39 6 23 24 80 0.172
Alex Bregman
3B
59 37 63 7 34 29 42 0.275
Chas McCormick
RF
59 30 36 10 35 13 54 0.245
Ryne Stanek
RP
40 0 0 0 0 0 0 0.000
Robel Garcia
2B
39 7 16 1 8 7 37 0.176

Cleveland Indians Pitching Stats

2021 Cleveland Indians Pitching
Top 12 by Wins and Games Played
Player GP W L SV HLD IP K WHIP ERA
Aaron Civale
SP
15 10 2 0 0 97.2 76 1.06 3.32
Shane Bieber
SP
14 7 4 0 0 90.2 130 1.25 3.28
James Karinchak
RP
45 6 2 11 9 43.1 69 1.06 2.91
Zach Plesac
SP
13 5 3 0 0 75.1 48 1.06 4.30
Bryan Shaw
RP
44 3 4 2 14 43.1 53 1.34 2.91
Emmanuel Clase
RP
42 3 5 11 6 40.0 43 1.25 2.03
Phil Maton
RP
36 2 0 0 3 39.2 59 1.29 4.54
Nick Wittgren
RP
34 2 3 1 8 33.0 37 1.21 5.73
Cal Quantrill
SP
28 2 2 0 1 72.2 50 1.35 3.84
Nick Sandlin
RP
26 1 0 0 4 27.1 39 1.17 2.63
Trevor Stephan
RP
24 1 0 0 1 34.0 42 1.50 4.24
Blake Parker
RP
17 1 0 0 1 15.2 11 1.28 2.87

Houston Astros Pitching Stats

2021 Houston Astros Pitching
Top 12 by Wins and Games Played
Player GP W L SV HLD IP K WHIP ERA
Zack Greinke
SP
20 9 3 0 0 120.2 89 1.12 3.58
Luis Garcia
SP
18 7 5 0 0 91.1 105 1.06 2.86
Lance McCullers Jr.
SP
16 7 2 0 0 91.2 107 1.20 3.04
Jose Urquidy
SP
14 6 3 0 0 77.1 66 0.96 3.38
Framber Valdez
SP
10 5 2 0 0 60.2 56 1.32 3.26
Ryan Pressly
RP
38 4 1 17 1 40.0 50 0.78 1.35
Bryan Abreu
SP
27 3 3 1 5 32.0 30 1.34 4.22
Brandon Bielak
RP
22 3 3 0 2 36.2 31 1.34 5.40
Cristian Javier
RP
21 3 1 1 4 74.2 93 1.06 2.89
Jake Odorizzi
SP
13 3 5 0 0 55.1 51 1.14 4.23
Brooks Raley
RP
36 2 3 2 8 30.1 40 1.35 5.93
Blake Taylor
SP
26 2 2 0 3 23.0 24 1.52 3.52

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