The Astros will play the Guardians on Wednesday, April 22nd, 2026. Your timezone's first pitch time is 1:11 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
| Bonus | |
|---|---|
 #1 BetMGMREVIEW | New Customers - Up to $1500 Paid Back in Bonus Bets Bonus Bets Expire in 7 Days One new customer offer/Add'l Terms Bet Now 21+ Playable in Ohio only Gambling Problem? Call 1-800-589-9966 |
Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - The Houston Astros have a 87.67 power ranking. The power ranking for the Cleveland Guardians is 92.67.
- Visiting Houston Astros - The Houston Astros have a 2-10 record as a visiting team, ranking them 8th Overall for visiting team wins.
- Home Cleveland Guardians - The Cleveland Guardians have a 8-4 record as a home team. They rank 2nd for home team wins in the Overall standings.
- Runs Scored - The Houston Astros currently stand 1st (135) Overall, with the Cleveland Guardians ranking 10th (105) for runs scored.
- Runs Allowed - The Houston Astros are 1st (150) Overall for runs allowed. The Cleveland Guardians stand 10th (109) for runs allowed.
- Team Streaks - The Houston Astros lost their last game. Meanwhile, the Cleveland Guardians won their last game.
- Team Records - The Houston Astros have a 9-16 Overall record (3.5 GB American West Division), with the Cleveland Guardians possessing a 14-11 Overall standing (0.0 GB American Central Division).
Captain Shady Lines
A broken compass is right at least twice a day.
Arrr me hearties, the scurvy Astros be sailin' to Cleveland for battle...
Against the Guardians, who be havin' a better record than us...
But don't ye worry, we be aimin' to plunder their treasure on Wednesday!
The Astros, with their pitiful record, be needin' to shape up quick...
Or they be walkin' the plank faster than ye can say "walk the plank"...
But fear not, mates, for we shall rise like the kraken and conquer!
If ye be lookin' to make some doubloons, head to SportsBetting3.com...
And bet on this game to show them landlubbers what we're made of...
Review the odds below, and let's make those scallywags walk the plank!
Best Astros at Guardians Odds
| Underdog Houston Astros | Favorite Cleveland Guardians |
|---|---|
| Over | Under |
|---|---|
| Underdog Houston Astros | Favorite Cleveland Guardians |
|---|---|
Matchup Odds FAQs
The Cleveland Guardians are the -160 moneyline favorite at BetMGM and the Houston Astros are the +135 moneyline underdog at BetMGM.
The best over line is 8 -105 runs at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 8 -115 runs at BetMGM, and that means you risk $115 to win $100 betting the under.
The Cleveland Guardians are -1.5 +145 run line favorites at BetMGM, while the Houston Astros are +1.5 -175 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Astros
Guardians
4/22/26 1:11pm EDT | +135-160 |
- Houston Astros bettors risk $100 to win $135 at +135 odds. The implied probability for Houston Astros is 42.55%.
- Cleveland Guardians bettors risk $100 to win $62.5 at -160 odds. The implied probability for Cleveland Guardians is 61.54%.
Houston Astros at Cleveland Guardians Prop Bets
| BetMGM Bet |
|
|---|---|
Astros
Guardians
First Team to Score
4/22/26 1:11pm EDT | -130+100Bet |
Astros
Guardians
Tie
1st Inning Winner
4/22/26 1:11pm EDT | +340+280-145Bet |
Astros
Guardians
Tie
First 3 Innings Winner
4/22/26 1:11pm EDT | +170+125+270Bet |
Astros
Guardians
To Extra Innings
4/22/26 1:11pm EDT | Yes +750No -1200Bet |
| BetMGM | |
Astros
Guardians
1st Team to Score Will Win
4/22/26 1:11pm EDT | Yes -250No +190Bet |
Guardians
Total Runs
HOU at CLE 4/22/26 1:11pm EDT | 4.5 o +1154.5 u -150Bet |
Astros
Total Runs
HOU at CLE 4/22/26 1:11pm EDT | 3.5 o -1103.5 u -118Bet |
Houston Astros & Cleveland Guardians Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Houston Astros World Series Odds|
Team | BetMGM |
|---|---|
| Astros | +6600 Bet |
|
Team | BetMGM |
|---|---|
| Guardians | +4500 Bet |
Houston Astros & Cleveland Guardians Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cleveland Guardians | 14 | 11 | 0.560 | +3.0 | 8-4 | 6-7 | 105 | 109 | -4 | W1 | 5-5 |
| Houston Astros | 9 | 16 | 0.360 | +8.0 | 7-6 | 2-10 | 135 | 150 | -15 | L1 | 3-7 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Houston Astros vs Cleveland Guardians MLB Game
-
Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, April 22nd, 2026 at 1:11 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
-
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
-
Tap to the sportsbook's MLB page, look for the Houston Astros vs Cleveland Guardians Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Houston Astros vs Cleveland Guardians Game.
-
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other April 22, 2026 MLB Games
- St. Louis Cardinals vs Miami Marlins - 4/22/26 12:10pm EDT
- Cincinnati Reds vs Tampa Bay Rays - 4/22/26 1:10pm EDT
- Baltimore Orioles vs Kansas City Royals - 4/22/26 2:10pm EDT
- Toronto Blue Jays vs Los Angeles Angels - 4/22/26 3:07pm EDT
- Oakland Athletics vs Seattle Mariners - 4/22/26 4:10pm EDT
- Milwaukee Brewers vs Detroit Tigers - 4/22/26 6:40pm EDT
- New York Yankees vs Boston Red Sox - 4/22/26 6:45pm EDT
- Atlanta Braves vs Washington Nationals - 4/22/26 6:45pm EDT
- Minnesota Twins vs New York Mets - 4/22/26 7:10pm EDT
- Philadelphia Phillies vs Chicago Cubs - 4/22/26 7:40pm EDT
- Pittsburgh Pirates vs Texas Rangers - 4/22/26 8:08pm EDT
- San Diego Padres vs Colorado Rockies - 4/22/26 8:40pm EDT
- Chicago White Sox vs Arizona Diamondbacks - 4/22/26 9:40pm EDT
- Los Angeles Dodgers vs San Francisco Giants - 4/22/26 9:45pm EDT