Houston Astros vs Cleveland Guardians Odds

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The Astros will play the Guardians on Wednesday, April 22nd, 2026. Your timezone's first pitch time is 1:11 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - The Houston Astros have a 87.67 power ranking. The power ranking for the Cleveland Guardians is 92.67.
  • Visiting Houston Astros - The Houston Astros have a 2-10 record as a visiting team, ranking them 8th Overall for visiting team wins.
  • Home Cleveland Guardians - The Cleveland Guardians have a 8-4 record as a home team. They rank 2nd for home team wins in the Overall standings.
  • Runs Scored - The Houston Astros currently stand 1st (135) Overall, with the Cleveland Guardians ranking 10th (105) for runs scored.
  • Runs Allowed - The Houston Astros are 1st (150) Overall for runs allowed. The Cleveland Guardians stand 10th (109) for runs allowed.
  • Team Streaks - The Houston Astros lost their last game. Meanwhile, the Cleveland Guardians won their last game.
  • Team Records - The Houston Astros have a 9-16 Overall record (3.5 GB American West Division), with the Cleveland Guardians possessing a 14-11 Overall standing (0.0 GB American Central Division).

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Arrr me hearties, the scurvy Astros be sailin' to Cleveland for battle...

Against the Guardians, who be havin' a better record than us...

But don't ye worry, we be aimin' to plunder their treasure on Wednesday!

The Astros, with their pitiful record, be needin' to shape up quick...

Or they be walkin' the plank faster than ye can say "walk the plank"...

But fear not, mates, for we shall rise like the kraken and conquer!

If ye be lookin' to make some doubloons, head to SportsBetting3.com...

And bet on this game to show them landlubbers what we're made of...

Review the odds below, and let's make those scallywags walk the plank!

Best Astros at Guardians Odds


Best Moneyline Betting Odds
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Best Total Betting Odds
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Best Run Line Betting Odds
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MLB Odds Example

MLB Odds and Outcomes Explained
Game Book

Houston Astros at Cleveland Guardians Prop Bets

MLB Prop Bets
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4/22/26 1:11pm EDT
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Houston Astros & Cleveland Guardians Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Houston Astros World Series Odds

No World Series TM Houston Astros YR: futures available

Cleveland Guardians World Series Odds

No World Series TM Cleveland Guardians YR: futures available

Houston Astros & Cleveland Guardians Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2026 MLB Regular Season Standings - Houston Astros, Cleveland Guardians
Team W L Pct GB Home Away RS RA Diff Strk L10
Cleveland Guardians65660.496+16.531-3434-32527536-9W46-4
Houston Astros65660.496+16.533-3532-31596640-44L24-6

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Houston Astros vs Cleveland Guardians MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, April 22nd, 2026 at 1:11 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the Houston Astros vs Cleveland Guardians Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Houston Astros vs Cleveland Guardians Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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