The Astros will play the Cardinals on Wednesday, March 18th, 2026. Your timezone's first pitch time is 1:05 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best Astros at Cardinals Odds
| Underdog St. Louis Cardinals | Favorite Houston Astros |
|---|---|
| Over | Under |
|---|
| TBD | TBD |
|---|
Matchup Odds FAQs
The Houston Astros are the -150 moneyline favorite at BetMGM and the St. Louis Cardinals are the +125 moneyline underdog at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Astros
Cardinals
3/18/26 1:05pm EDT | -150+125 |
- St. Louis Cardinals bettors risk $100 to win $125 at +125 odds. The implied probability for St. Louis Cardinals is 44.44%.
- Houston Astros bettors risk $100 to win $66.67 at -150 odds. The implied probability for Houston Astros is 60%.
Houston Astros at St. Louis Cardinals Prop Bets
| BetMGM Bet |
|
|---|---|
Astros
Cardinals
3/18/26 1:05pm EDT | Pending BetMGM |
Houston Astros & St. Louis Cardinals Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Houston Astros World Series Odds|
Team | BetMGM |
|---|---|
| Astros | +4000 Bet |
|
Team | BetMGM |
|---|---|
| Cardinals | +15000 Bet |
Houston Astros & St. Louis Cardinals Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| St. Louis Cardinals | 14 | 9 | 0.609 | +2.0 | 7-5 | 7-4 | 111 | 119 | -8 | W1 | 6-4 |
| Houston Astros | 9 | 16 | 0.360 | +8.0 | 7-6 | 2-10 | 135 | 150 | -15 | L1 | 3-7 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Houston Astros vs St. Louis Cardinals MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, March 18th, 2026 at 1:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Houston Astros vs St. Louis Cardinals Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Houston Astros vs St. Louis Cardinals Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.