The Giants will play the Padres on Thursday, August 21st, 2025. Your timezone's first pitch time is 4:10 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best Giants at Padres Odds
| Underdog San Francisco Giants | Favorite San Diego Padres |
|---|---|
| Over | Under |
|---|---|
| Underdog San Francisco Giants | Favorite San Diego Padres |
|---|---|
Matchup Odds FAQs
The San Diego Padres are the -185 moneyline favorite at BetMGM and the San Francisco Giants are the +150 moneyline underdog at BetMGM.
The best over line is 7.5 -118 runs at BetMGM, which means you risk $118 to win $100 betting the over. The best under line is 7.5 -102 runs at BetMGM, and that means you risk $102 to win $100 betting the under.
The San Diego Padres are -1.5 +125 run line favorites at BetMGM, while the San Francisco Giants are +1.5 -150 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Giants
Padres
8/21/25 4:10pm EDT | +150-185 |
- San Francisco Giants bettors risk $100 to win $150 at +150 odds. The implied probability for San Francisco Giants is 40%.
- San Diego Padres bettors risk $100 to win $54.05 at -185 odds. The implied probability for San Diego Padres is 64.91%.
San Francisco Giants at San Diego Padres Prop Bets
| BetMGM Bet |
|
|---|---|
Giants
Padres
First Team to Score
8/21/25 4:10pm EDT | -115-110Bet |
Giants
Padres
Tie
1st Inning Winner
8/21/25 4:10pm EDT | +375+250-140Bet |
Giants
Padres
Tie
First 3 Innings Winner
8/21/25 4:10pm EDT | +195+105+280Bet |
Giants
Padres
To Extra Innings
8/21/25 4:10pm EDT | Yes +725No -1200Bet |
| BetMGM | |
Giants
Padres
1st Team to Score Will Win
8/21/25 4:10pm EDT | Yes -250No +190Bet |
Padres
Total Runs
SFO at SDG 8/21/25 4:10pm EDT | 4.5 o +1054.5 u -140Bet |
Giants
Total Runs
SFO at SDG 8/21/25 4:10pm EDT | 3.5 o +1053.5 u -140Bet |
Dylan Cease
Strikeouts Thrown
SFO at SDG 8/21/25 4:10pm EDT | 6.5 o -1456.5 u +110Bet |
| BetMGM | |
Justin Verlander
Strikeouts Thrown
SFO at SDG 8/21/25 4:10pm EDT | 3.5 o -1753.5 u +130Bet |
San Francisco Giants & San Diego Padres Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
San Francisco Giants World Series Odds|
Team | BetMGM |
|---|---|
| Giants | +100000 Bet |
|
Team | BetMGM |
|---|---|
| Padres | +1000 Bet |
San Francisco Giants & San Diego Padres Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| San Diego Padres | 75 | 59 | 0.560 | +7.5 | 43-22 | 32-37 | 564 | 510 | +54 | L1 | 6-4 |
| San Francisco Giants | 66 | 68 | 0.493 | +16.5 | 33-33 | 33-35 | 551 | 548 | +3 | W5 | 6-4 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco Giants vs San Diego Padres MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Thursday, August 21st, 2025 at 4:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the San Francisco Giants vs San Diego Padres Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the San Francisco Giants vs San Diego Padres Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other August 21, 2025 MLB Games
- Oakland Athletics vs Minnesota Twins - 8/21/25 1:10pm EDT
- Texas Rangers vs Kansas City Royals - 8/21/25 2:10pm EDT
- Milwaukee Brewers vs Chicago Cubs - 8/21/25 2:20pm EDT
- Los Angeles Dodgers vs Colorado Rockies - 8/21/25 3:10pm EDT
- New York Mets vs Washington Nationals - 8/21/25 4:05pm EDT
- Houston Astros vs Baltimore Orioles - 8/21/25 7:15pm EDT
- Boston Red Sox vs New York Yankees - 8/21/25 7:15pm EDT
- St. Louis Cardinals vs Tampa Bay Rays - 8/21/25 7:35pm EDT