San Francisco Giants vs San Diego Padres Odds

The Giants will play the Padres on Wednesday, April 1st, 2026. Your timezone's first pitch time is 4:10 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - The San Francisco Giants have a 91.67 power ranking. The power ranking for the San Diego Padres is 92.00.
  • Visiting San Francisco Giants - The San Francisco Giants have a 1-0 record as a visiting team, ranking them 4th Overall for visiting team wins.
  • Home San Diego Padres - The San Diego Padres have a 1-3 record as a home team. They rank 4th for home team wins in the Overall standings.
  • Runs Scored - The San Francisco Giants currently stand 19th (4) Overall, with the San Diego Padres ranking 18th (9) for runs scored.
  • Runs Allowed - The San Francisco Giants are 14th (15) Overall for runs allowed. The San Diego Padres stand 13th (16) for runs allowed.
  • Team Streaks - The San Francisco Giants won their last game. Meanwhile, the San Diego Padres lost their last game.
  • Team Records - The San Francisco Giants have a 1-3 Overall record (2.0 GB National West Division), with the San Diego Padres possessing a 1-3 Overall standing (2.0 GB National West Division).

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Arrr, ye scurvy dogs! The Giants be playin' the Padres with a dismal record...

Both teams be sittin' at a pitiful 1-3 overall, win percentage be abysmal...

If ye be brave enough, head to SportsBetting3.com and bet on this game... Review the odds below, but don't be expectin' a win from these landlubbers!

Best Giants at Padres Odds


Best Moneyline Betting Odds
Underdog

San Francisco Giants
Favorite

San Diego Padres
The San Diego Padres are the -150 moneyline favorite. Risk $150 to win $100 on the San Diego Padres at BetMGM. The San Francisco Giants are the +125 underdog at BetMGM. Risk $100 to win $125 on the San Francisco Giants. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 8 runs. Risk $105 to win $100. BetMGM has the best under line of 8 runs. Risk $115 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

San Francisco Giants
Favorite

San Diego Padres
The San Diego Padres have a -1.5 +150 run line at BetMGM OH. They are the run line favorite in this matchup. The San Francisco Giants have a +1.5 -185 run line at BetMGM OH. The San Francisco Giants are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the San Francisco Giants vs San Diego Padres MLB game on Wednesday, April 1st, 2026?

The San Diego Padres are the -150 moneyline favorite at BetMGM and the San Francisco Giants are the +125 moneyline underdog at BetMGM.

What is the over-under total line for the San Francisco Giants vs San Diego Padres MLB game on Wednesday, April 1st, 2026?

The best over line is 8 -105 runs at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 8 -115 runs at BetMGM, and that means you risk $115 to win $100 betting the under.

What is the run line for the San Francisco Giants vs San Diego Padres MLB game on Wednesday, April 1st, 2026?

The San Diego Padres are -1.5 +150 run line favorites at BetMGM, while the San Francisco Giants are +1.5 -185 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Giants
Padres
4/01/26 4:10pm EDT
+125-150
Bet $100 at BetMGM Ohio
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Possible Moneyline Outcomes
  • San Francisco Giants bettors risk $100 to win $125 at +125 odds. The implied probability for San Francisco Giants is 44.44%.
  • San Diego Padres bettors risk $100 to win $66.67 at -150 odds. The implied probability for San Diego Padres is 60%.

San Francisco Giants at San Diego Padres Prop Bets

MLB Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Giants
Padres
First Team to Score
4/01/26 4:10pm EDT
-120-105Bet
Giants
Padres
Tie
1st Inning Winner
4/01/26 4:10pm EDT
+375+275-150Bet
Giants
Padres
Tie
First 3 Innings Winner
4/01/26 4:10pm EDT
+195+115+250Bet
Giants
Padres
To Extra Innings
4/01/26 4:10pm EDT
Yes +750No -1200Bet
BetMGM Sports Betting BetMGM
Giants
Padres
1st Team to Score Will Win
4/01/26 4:10pm EDT
Yes -250No +190Bet
Padres
Total Runs
SFO at SDG
4/01/26 4:10pm EDT
4.5 o +1154.5 u -150Bet
Giants
Total Runs
SFO at SDG
4/01/26 4:10pm EDT
3.5 o -1183.5 u -110Bet

San Francisco Giants & San Diego Padres Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

San Francisco Giants World Series Odds
2026 San Francisco Giants World Series Odds

Team
BetMGM Sports Betting BetMGM
Giants
+10000
Bet
San Diego Padres World Series Odds
2026 San Diego Padres World Series Odds

Team
BetMGM Sports Betting BetMGM
Padres
+3000
Bet

San Francisco Giants & San Diego Padres Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2026 MLB Regular Season Standings - San Francisco Giants, San Diego Padres
Team W L Pct GB Home Away RS RA Diff Strk L10
San Diego Padres1670.6960.09-47-39779+18W39-1
San Francisco Giants10130.435+6.04-76-67897-19W15-5

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco Giants vs San Diego Padres MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, April 1st, 2026 at 4:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the San Francisco Giants vs San Diego Padres Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the San Francisco Giants vs San Diego Padres Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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