San Francisco Giants vs Seattle Mariners Odds

The Giants will play the Mariners on Saturday, February 21st, 2026. Your timezone's first pitch time is 3:10 pm EST. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Best Giants at Mariners Odds


Best Moneyline Betting Odds
Underdog

Seattle Mariners
Favorite

San Francisco Giants
The San Francisco Giants are the -115 moneyline favorite. Risk $115 to win $100 on the San Francisco Giants at BetMGM. The Seattle Mariners are the -105 underdog at BetMGM. Risk $105 to win $100 on the Seattle Mariners. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 10.5 runs. Risk $100 to win $105. BetMGM has the best under line of 10.5 runs. Risk $125 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

Seattle Mariners
Favorite

San Francisco Giants
The San Francisco Giants have a -1.5 +140 run line at BetMGM OH. They are the run line favorite in this matchup. The Seattle Mariners have a +1.5 -170 run line at BetMGM OH. The Seattle Mariners are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the San Francisco Giants vs Seattle Mariners MLB game on Saturday, February 21st, 2026?

The San Francisco Giants are the -115 moneyline favorite at BetMGM and the Seattle Mariners are the -105 moneyline underdog at BetMGM.

What is the over-under total line for the San Francisco Giants vs Seattle Mariners MLB game on Saturday, February 21st, 2026?

The best over line is 10.5 +105 runs at BetMGM, which means you risk $100 to win $105 betting the over. The best under line is 10.5 -125 runs at BetMGM, and that means you risk $125 to win $100 betting the under.

What is the run line for the San Francisco Giants vs Seattle Mariners MLB game on Saturday, February 21st, 2026?

The San Francisco Giants are -1.5 +140 run line favorites at BetMGM, while the Seattle Mariners are +1.5 -170 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Giants
Mariners
2/21/26 3:10pm EST
-115-105
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Possible Moneyline Outcomes
  • Seattle Mariners bettors risk $100 to win $95.24 at -105 odds. The implied probability for Seattle Mariners is 51.22%.
  • San Francisco Giants bettors risk $100 to win $86.96 at -115 odds. The implied probability for San Francisco Giants is 53.49%.

San Francisco Giants at Seattle Mariners Prop Bets

MLB Prop Bets
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BetMGM Sports Betting BetMGM
Bet
Giants
Mariners
2/21/26 3:10pm EST
Pending BetMGM

San Francisco Giants & Seattle Mariners Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

San Francisco Giants World Series Odds
2026 San Francisco Giants World Series Odds

Team
BetMGM Sports Betting BetMGM
Giants
+6600
Bet
Seattle Mariners World Series Odds
2026 Seattle Mariners World Series Odds

Team
BetMGM Sports Betting BetMGM
Mariners
+1300
Bet

San Francisco Giants & Seattle Mariners Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - San Francisco Giants, Seattle Mariners
Team W L Pct GB Home Away RS RA Diff Strk L10
x - Seattle Mariners90720.556+7.051-3039-42766694+72L37-3
e - San Francisco Giants81810.500+16.042-3939-42705684+21W45-5

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco Giants vs Seattle Mariners MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Saturday, February 21st, 2026 at 3:10 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the San Francisco Giants vs Seattle Mariners Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the San Francisco Giants vs Seattle Mariners Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other February 21, 2026 MLB Games

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