The Giants will play the Cardinals on Saturday, September 6th, 2025. Your timezone's first pitch time is 7:15 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best Giants at Cardinals Odds
| Underdog St. Louis Cardinals | Favorite San Francisco Giants |
|---|---|
| Over | Under |
|---|---|
| Underdog St. Louis Cardinals | Favorite San Francisco Giants |
|---|---|
Matchup Odds FAQs
The San Francisco Giants are the -130 moneyline favorite at BetMGM and the St. Louis Cardinals are the +110 moneyline underdog at BetMGM.
The best over line is 8.5 -105 runs at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 8.5 -115 runs at BetMGM, and that means you risk $115 to win $100 betting the under.
The San Francisco Giants are -1.5 +135 run line favorites at BetMGM, while the St. Louis Cardinals are +1.5 -160 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Giants
Cardinals
7:15pm EDT | -130+110 |
- St. Louis Cardinals bettors risk $100 to win $110 at +110 odds. The implied probability for St. Louis Cardinals is 47.62%.
- San Francisco Giants bettors risk $100 to win $76.92 at -130 odds. The implied probability for San Francisco Giants is 56.52%.
San Francisco Giants at St. Louis Cardinals Prop Bets
| BetMGM Bet |
|
|---|---|
Giants
Cardinals
First Team to Score
7:15pm EDT | -180+140Bet |
Giants
Cardinals
Tie
1st Inning Winner
7:15pm EDT | +260+325-135Bet |
Giants
Cardinals
Tie
First 3 Innings Winner
7:15pm EDT | +120+160+290Bet |
Giants
Cardinals
To Extra Innings
7:15pm EDT | Yes +750No -1200Bet |
| BetMGM | |
Giants
Cardinals
1st Team to Score Will Win
7:15pm EDT | Yes -250No +190Bet |
Giants
Total Runs
SFO at STL 7:15pm EDT | 4.5 o +1004.5 u -130Bet |
Cardinals
Total Runs
SFO at STL 7:15pm EDT | 3.5 o -1303.5 u +100Bet |
Andre Pallante
Strikeouts Thrown
SFO at STL 7:15pm EDT | 3.5 o +1003.5 u -135Bet |
| BetMGM | |
Justin Verlander
Strikeouts Thrown
SFO at STL 7:15pm EDT | 5.5 o +1005.5 u -135Bet |
San Francisco Giants & St. Louis Cardinals Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
San Francisco Giants World Series Odds|
Team | BetMGM |
|---|---|
| Giants | +10000 Bet |
|
Team | BetMGM |
|---|---|
| Cardinals | +100000 Bet |
San Francisco Giants & St. Louis Cardinals Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| San Francisco Giants | 72 | 69 | 0.511 | +15.0 | 35-34 | 37-35 | 613 | 585 | +28 | W5 | 9-1 |
| St. Louis Cardinals | 70 | 72 | 0.493 | +17.5 | 39-34 | 31-38 | 615 | 657 | -42 | L1 | 5-5 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco Giants vs St. Louis Cardinals MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 6th, 2025 at 7:15 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the San Francisco Giants vs St. Louis Cardinals Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the San Francisco Giants vs St. Louis Cardinals Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 6, 2025 MLB Games
- Toronto Blue Jays vs New York Yankees - 1:05pm EDT
- Washington Nationals vs Chicago Cubs - 2:20pm EDT
- Philadelphia Phillies vs Miami Marlins - 4:10pm EDT
- Chicago White Sox vs Detroit Tigers - 6:10pm EDT
- Milwaukee Brewers vs Pittsburgh Pirates - 6:40pm EDT
- New York Mets vs Cincinnati Reds - 6:40pm EDT
- Los Angeles Dodgers vs Baltimore Orioles - 7:05pm EDT
- Cleveland Guardians vs Tampa Bay Rays - 7:05pm EDT
- Minnesota Twins vs Kansas City Royals - 7:15pm EDT
- Seattle Mariners vs Atlanta Braves - 7:15pm EDT
- Houston Astros vs Texas Rangers - 7:15pm EDT
- Boston Red Sox vs Arizona Diamondbacks - 8:10pm EDT
- San Diego Padres vs Colorado Rockies - 8:10pm EDT
- Oakland Athletics vs Los Angeles Angels - 9:38pm EDT