The Cardinals will play the Guardians on Sunday, June 29th, 2025. Your timezone's first pitch time is 12:05 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - As the 2025 season continues, the St. Louis Cardinals possess a 95.33 SportsBetting3.com power ranking. The Cleveland Guardians now have a 90.00 power ranking. Teams with a higher SportsBetting3.com power ranking will typically be moneyline favorites.
- Visiting St. Louis Cardinals - The St. Louis Cardinals head into this matchup with a 11-16 record as a visiting team. This standing ranks them 7th Overall for visiting team wins.
- Home Cleveland Guardians - The Cleveland Guardians will throw the first pitch possessing a 14-10 home team record. That puts them 6th for home team wins in the Overall MLB standings.
- Runs Scored - St. Louis Cardinals batters have produced 256 runs, ranking them 8th Overall, with the Cleveland Guardians ranking 19th (216) for runs scored.
- Runs Allowed - St. Louis Cardinals pitchers and fielders have allowed 216 runs, ranking them 18th Overall for runs allowed. Meanwhile, the Cleveland Guardians now rank 11th Overall, allowing 236 runs.
- Team Streaks - The St. Louis Cardinals lost their last game. Their opponent, the Cleveland Guardians have lost their last 3 games.
- Team Records - Let's review each team's records. The St. Louis Cardinals have a 30-24 Overall record (3.0 GB National Central Division), with the Cleveland Guardians notching a 29-25 Overall standing (6.0 GB American Central Division).
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scallywags! The Cardinals be takin' on them Guardians in Cleveland... (Arrr, they be lookin' to plunder a victory on enemy waters!)
With a record of 30-24, the Cardinals be fightin' with all their might... (But the Guardians be lookin' to defend their home turf fiercely!)
The Cardinals be showin' their strength with a 0.556 win percentage... (But the Guardians be no pushovers with a record of 29-25!)
Ye best be keepin' a weather eye on this match-up... (As the battle on the diamond promises to be fierce and thrilling!)
Check out this game's prop bets below, bet on MLB baseball at legal US sportsbooks, review each team's standing at the bottom of the page.
Best Cardinals at Guardians Odds
| Underdog Cleveland Guardians | Favorite St. Louis Cardinals |
|---|---|
| Over | Under |
|---|---|
| Underdog Cleveland Guardians | Favorite St. Louis Cardinals |
|---|---|
Matchup Odds FAQs
The St. Louis Cardinals are the -118 moneyline favorite at BetMGM and the Cleveland Guardians are the -102 moneyline underdog at BetMGM.
The best over line is 8.5 -105 runs at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 8.5 -115 runs at BetMGM, and that means you risk $115 to win $100 betting the under.
The St. Louis Cardinals are -1.5 +145 run line favorites at BetMGM, while the Cleveland Guardians are +1.5 -175 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Cardinals
Guardians
6/29/25 12:05pm EDT | -118-102 |
- Cleveland Guardians bettors risk $100 to win $98.04 at -102 odds. The implied probability for Cleveland Guardians is 50.5%.
- St. Louis Cardinals bettors risk $100 to win $84.75 at -118 odds. The implied probability for St. Louis Cardinals is 54.13%.
St. Louis Cardinals at Cleveland Guardians Prop Bets
| BetMGM Bet |
|
|---|---|
Cardinals
Guardians
First Team to Score
6/29/25 12:05pm EDT | -175+135Bet |
Cardinals
Guardians
Tie
1st Inning Winner
6/29/25 12:05pm EDT | +270+325-135Bet |
Cardinals
Guardians
Tie
First 3 Innings Winner
6/29/25 12:05pm EDT | +125+160+290Bet |
Cardinals
Guardians
To Extra Innings
6/29/25 12:05pm EDT | Yes +725No -1200Bet |
| BetMGM | |
Cardinals
Guardians
1st Team to Score Will Win
6/29/25 12:05pm EDT | Yes -250No +190Bet |
Guardians
Total Runs
STL at CLE 6/29/25 12:05pm EDT | 3.5 o -1403.5 u +105Bet |
Cardinals
Total Runs
STL at CLE 6/29/25 12:05pm EDT | 4.5 o +1054.5 u -140Bet |
Logan Allen
Strikeouts Thrown
STL at CLE 6/29/25 12:05pm EDT | 4.5 o +1054.5 u -135Bet |
| BetMGM | |
Matthew Liberatore
Strikeouts Thrown
STL at CLE 6/29/25 12:05pm EDT | 4.5 o +1054.5 u -140Bet |
St. Louis Cardinals & Cleveland Guardians Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
St. Louis Cardinals World Series Odds|
Team | BetMGM |
|---|---|
| Cardinals | +8000 Bet |
|
Team | BetMGM |
|---|---|
| Guardians | +15000 Bet |
St. Louis Cardinals & Cleveland Guardians Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| St. Louis Cardinals | 50 | 46 | 0.521 | +9.0 | 28-20 | 22-26 | 439 | 423 | +16 | L2 | 3-7 |
| Cleveland Guardians | 45 | 49 | 0.479 | +13.0 | 20-23 | 25-26 | 347 | 393 | -46 | W1 | 5-5 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the St. Louis Cardinals vs Cleveland Guardians MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, June 29th, 2025 at 12:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the St. Louis Cardinals vs Cleveland Guardians Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the St. Louis Cardinals vs Cleveland Guardians Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other June 29, 2025 MLB Games
- Tampa Bay Rays vs Baltimore Orioles - 6/29/25 1:35pm EDT
- Toronto Blue Jays vs Boston Red Sox - 6/29/25 1:35pm EDT
- Oakland Athletics vs New York Yankees - 6/29/25 1:35pm EDT
- Philadelphia Phillies vs Atlanta Braves - 6/29/25 1:35pm EDT
- New York Mets vs Pittsburgh Pirates - 6/29/25 1:35pm EDT
- San Diego Padres vs Cincinnati Reds - 6/29/25 1:40pm EDT
- San Francisco Giants vs Chicago White Sox - 6/29/25 2:10pm EDT
- Los Angeles Dodgers vs Kansas City Royals - 6/29/25 2:10pm EDT
- Colorado Rockies vs Milwaukee Brewers - 6/29/25 2:10pm EDT
- Chicago Cubs vs Houston Astros - 6/29/25 2:10pm EDT
- Seattle Mariners vs Texas Rangers - 6/29/25 2:35pm EDT
- Washington Nationals vs Los Angeles Angels - 6/29/25 4:07pm EDT
- Miami Marlins vs Arizona Diamondbacks - 6/29/25 4:10pm EDT
- Minnesota Twins vs Detroit Tigers - 6/29/25 7:10pm EDT