St. Louis Cardinals vs San Francisco Giants Odds

The Cardinals will play the Giants on Wednesday, September 24th, 2025. Your timezone's first pitch time is 9:45 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

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Best Cardinals at Giants Odds

**Best Moneyline Betting Odds**
Underdog San Francisco Giants	Favorite St. Louis Cardinals
-105 BetMGM Bet	-115 BetMGM Bet

The St. Louis Cardinals are the -115 moneyline favorite. Risk $115 to win $100 on the St. Louis Cardinals at BetMGM. The San Francisco Giants are the -105 underdog at BetMGM. Risk $105 to win $100 on the San Francisco Giants. Learn more about how to bet on money lines.

**Best Total Betting Odds**
Over	Under
7.5 o -118 BetMGM Bet	7.5 u -102 BetMGM Bet

BetMGM has the best over line of 7.5 runs. Risk $118 to win $100. BetMGM has the best under line of 7.5 runs. Risk $102 to win $100. Our tutorial explains more about total bets.

**Best Run Line Betting Odds**
Underdog San Francisco Giants	Favorite St. Louis Cardinals
+1.5 -190 BetMGM Bet	-1.5 +155 BetMGM Bet

The St. Louis Cardinals have a -1.5 +155 run line at BetMGM OH. They are the run line favorite in this matchup. The San Francisco Giants have a +1.5 -190 run line at BetMGM OH. The San Francisco Giants are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the St. Louis Cardinals vs San Francisco Giants MLB game on Wednesday, September 24th, 2025?

The St. Louis Cardinals are the -115 moneyline favorite at BetMGM and the San Francisco Giants are the -105 moneyline underdog at BetMGM.

What is the over-under total line for the St. Louis Cardinals vs San Francisco Giants MLB game on Wednesday, September 24th, 2025?

The best over line is 7.5 -118 runs at BetMGM, which means you risk $118 to win $100 betting the over. The best under line is 7.5 -102 runs at BetMGM, and that means you risk $102 to win $100 betting the under.

What is the run line for the St. Louis Cardinals vs San Francisco Giants MLB game on Wednesday, September 24th, 2025?

The St. Louis Cardinals are -1.5 +155 run line favorites at BetMGM, while the San Francisco Giants are +1.5 -190 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained
Game	BetMGM Bet
Cardinals Giants 9/24/25 9:45pm EDT	-115 -105

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Possible Moneyline Outcomes

San Francisco Giants bettors risk $100 to win $95.24 at -105 odds. The implied probability for San Francisco Giants is 51.22%.
St. Louis Cardinals bettors risk $100 to win $86.96 at -115 odds. The implied probability for St. Louis Cardinals is 53.49%.

St. Louis Cardinals at San Francisco Giants Prop Bets

MLB Prop Bets
+ Displays more odds
	BetMGM Bet
Cardinals Giants First Team to Score 9/24/25 9:45pm EDT	-155 +120 Bet
Cardinals Giants Tie 1st Inning Winner 9/24/25 9:45pm EDT	+300 +325 -150 Bet
Cardinals Giants Tie First 3 Innings Winner 9/24/25 9:45pm EDT	+145 +145 +260 Bet
Cardinals Giants To Extra Innings 9/24/25 9:45pm EDT	Yes +725 No -1200 Bet
	BetMGM
Cardinals Giants 1st Team to Score Will Win 9/24/25 9:45pm EDT	Yes -250 No +190 Bet
Giants Total Runs STL at SFO 9/24/25 9:45pm EDT	3.5 o -125 3.5 u -105 Bet
Cardinals Total Runs STL at SFO 9/24/25 9:45pm EDT	3.5 o -140 3.5 u +105 Bet
Sonny Gray Strikeouts Thrown STL at SFO 9/24/25 9:45pm EDT	5.5 o -155 5.5 u +120 Bet

St. Louis Cardinals & San Francisco Giants Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

St. Louis Cardinals World Series Odds

No World Series TM St. Louis Cardinals YR: futures available

San Francisco Giants World Series Odds

No World Series TM San Francisco Giants YR: futures available

St. Louis Cardinals & San Francisco Giants Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - St. Louis Cardinals, San Francisco Giants
Team	W	L	Pct	GB	Home	Away	RS	RA	Diff	Strk	L10
e - San Francisco Giants	81	81	0.500	+16.0	42-39	39-42	705	684	+21	W4	5-5
e - St. Louis Cardinals	78	84	0.481	+19.0	44-37	34-47	689	754	-65	L4	4-6

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the St. Louis Cardinals vs San Francisco Giants MLB Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, September 24th, 2025 at 9:45 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's MLB page, look for the St. Louis Cardinals vs San Francisco Giants Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the St. Louis Cardinals vs San Francisco Giants Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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