Northwestern vs USC Basketball Odds

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The Wildcats will play the Trojans on Wednesday, January 21st, 2026. Your timezone's tip off time is 11:00 pm EST. Check local listings or your nearest streaming app for coverage.

Review our College Basketball Betting guide to learn how to bet this game.


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Table of Contents

Key Matchup Stats

Looking into the second half of the 2025-26 college basketball season, Northwestern and USC are set to hit the hardwood on Wednesday, January 21st, 2026. Luckily, we have some clear performance trends emerging now that each team has more than a dozen games under their belts. Use the following data to help analyze this matchup and to place an intelligent wager on its ultimate outcome.

  • SportsBetting3.com Power Rankings - With the 2025-26 season in full stride, Northwestern currently has a 88.33 conference power ranking, while the SportsBetting3.com conference power ranking for USC is 94.33.
  • Away Northwestern - Northwestern starts this game with a 1-3 record as an away team, ranking them 5th in the Big Ten Conference for away team wins.
  • Home USC - USC meets Northwestern boasting a 7-2 record as a home team. They currently rank 5th in the Big Ten Conference for home team wins.
  • Conference Win Percentage - Northwestern currently ranks 13th (0.000) in the Big Ten Conference, with USC now standing 7th (0.429) for their conference win percentage in the 2025 Big Ten Conference for the 2025-26 college basketball season.
  • Overall Win Percentage - Northwestern has a 0.444 overall win percentage, with USC matching up with a 0.778 overall win percentage.
  • Team Records - Northwestern currently possesses 8-10 regular season overall record. Meanwhile, USC has tallied a 14-4 standing as the 2025-26 college basketball season continues to unfold.

Moneyline Mage

Spelling out the winners with humor since the middle ages.

Moneyline Mage
Moneyline Mage

Hocus pocus! Northwestern faces USC in a magical matchup on January 21st.

Northwestern 8-10 overall, 0-7 in conference. USC 14-4 overall, 3-4 in conference.

Review the tables below to find the best point spread, total, and moneylines for this game. You can bet on college basketball legally at BetRivers and BetMGM. We've also listed each team's futures odds and current standings below.

Best Wildcats at Trojans Odds


Best Point Spread Betting Odds
Underdog

Northwestern		Favorite

USC
+5.5 -105 BetMGM
Bet
-5.5 -115 BetMGM
Bet
USC has a -5.5 -115 point spread at BetMGM OH. They are the point spread favorite in this matchup. Northwestern has a +5.5 -105 point spread at BetMGM OH. Northwestern is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
149.5 o -110 BetMGM
Bet
149.5 u -110 BetMGM
Bet
BetMGM has the best over line of 149.5 points. Risk $110 to win $100. BetMGM has the best under line of 149.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

Northwestern		Favorite

USC
+200 BetMGM
Bet
-250 BetMGM
Bet
USC is the -250 moneyline favorite. Risk $250 to win $100 on USC at BetMGM. Northwestern is the +200 underdog at BetMGM. Risk $100 to win $200 on Northwestern. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Northwestern vs USC College Basketball game on Wednesday, January 21st, 2026?

USC is a -5.5 -115 point spread favorite at BetMGM, while Northwestern is a +5.5 -105 point spread underdog at BetMGM.

What is the over-under total line for the Northwestern vs USC College Basketball game on Wednesday, January 21st, 2026?

The best over line is 149.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 149.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Northwestern vs USC College Basketball game on Wednesday, January 21st, 2026?

USC is a -250 moneyline favorite at BetMGM and Northwestern is a +200 moneyline underdog at BetMGM.

College Basketball Odds Example

College Basketball Odds and Outcomes Explained

Game		 BetMGM Sports Betting BetMGM
Bet
Northwestern
USC
1/21/26 11:00pm EST
+5.5 -105-5.5 -115
Bet $100 at BetMGM Ohio
21+ Playable in Ohio only
Gambling Problem? Call 1-800-589-9966

Underdog Northwestern - Northwestern bettors risk $100 to win $95.24 at -105 odds.

A +5.5 Northwestern underdog bet wins if they lose by 5 or fewer, tie, or win outright. Your bet loses if they lose by 6 or more.

Favorite USC - USC bettors risk $100 to win $86.96 at -115 odds.

A -5.5 USC favorite bet wins if they win by 6 or more. Your bet loses if they win by 5 or fewer, tie, or lose outright.

Northwestern at USC Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Basketball Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Northwestern
USC
First to 5 Points
1/21/26 11:00pm EST
+105-145Bet
Northwestern
USC
First to 10 Points
1/21/26 11:00pm EST
+110-155Bet
Northwestern
USC
First to 15 Points
1/21/26 11:00pm EST
+120-165Bet
Northwestern
USC
Game to Overtime
1/21/26 11:00pm EST
Yes +825No -3000Bet

Team Standings

2025-2026 College Basketball Regular Season Standings - Northwestern, USC
Team W-L Win% Home Away Conf CGB Conf% Strk
USC15-50.7507-34-24-5+50.444W1
Northwestern9-110.4506-52-41-8+80.111L1

Northwestern & USC Futures Odds

Latest College Basketball Championship odds, if available, for each team. Review March Madness odds for other teams and learn how to bet on the college basketball tournament. Also be sure to read Ron Halfback's Final Four write-up.

Northwestern Championship Odds
2025-26 Northwestern NCAA Men's Basketball Tournament Odds

Team
OH,US ncaabb Evnum: 1 Odds Pending
USC Championship Odds
2025-26 USC NCAA Men's Basketball Tournament Odds

Team
OH,US ncaabb Evnum: 1 Odds Pending

Northwestern & USC Team Pages

Review each team's futures odds, betting bonuses, current standings and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Northwestern vs USC College Basketball Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, January 21st, 2026 at 11:00 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's College Basketball page, look for the Northwestern vs USC Game.

    Navigate to the sportsbook's College Basketball page. Next, look for live or upcoming matchups. Select the Northwestern vs USC Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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