Notre Dame vs Louisville Basketball Odds

The Fighting Irish will play the Cardinals on Wednesday, February 4th, 2026. Your timezone's tip off time is 7:00 pm EST. Check local listings or your nearest streaming app for coverage.

Review our College Basketball Betting guide to learn how to bet this game.


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Table of Contents

Key Matchup Stats

Looking into the second half of the 2025-26 college basketball season, Notre Dame and Louisville are set to hit the hardwood on Wednesday, February 4th, 2026. Luckily, we have some clear performance trends emerging now that each team has more than a dozen games under their belts. Use the following data to help analyze this matchup and to place an intelligent wager on its ultimate outcome.

  • SportsBetting3.com Power Rankings - With the 2025-26 season in full stride, Notre Dame currently has a 92.33 conference power ranking, while the SportsBetting3.com conference power ranking for Louisville is 96.00.
  • Away Notre Dame - Notre Dame starts this game with a 2-5 record as an away team, ranking them 6th in the ACC Conference for away team wins.
  • Home Louisville - Louisville meets Notre Dame boasting a 11-2 record as a home team. They currently rank 3rd in the ACC Conference for home team wins.
  • Conference Win Percentage - Notre Dame currently ranks 11th (0.222) in the ACC Conference, with Louisville now standing 5th (0.556) for their conference win percentage in the 2025 ACC Conference for the 2025-26 college basketball season.
  • Overall Win Percentage - Notre Dame has a 0.500 overall win percentage, with Louisville matching up with a 0.714 overall win percentage.
  • Team Records - Notre Dame currently possesses 11-11 regular season overall record. Meanwhile, Louisville has tallied a 15-6 standing as the 2025-26 college basketball season continues to unfold.

Moneyline Mage

Spelling out the winners with humor since the middle ages.

Moneyline Mage
Moneyline Mage

Hocus pocus! Notre Dame, 11-11, faces Louisville, 15-6, in a magical matchup.

Conference records crucial for tournament seeds. Notre Dame, 2-7, vs Louisville, 5-4.

Review the tables below to find the best point spread, total, and moneylines for this game. You can bet on college basketball legally at BetRivers and BetMGM. We've also listed each team's futures odds and current standings below.

Best Fighting Irish at Cardinals Odds


Best Point Spread Betting Odds
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Best Total Betting Odds
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Best Moneyline Betting Odds
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Notre Dame at Louisville Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

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Team Standings

2025-2026 College Basketball Regular Season Standings - Notre Dame, Louisville
Team W-L Win% Home Away Conf CGB Conf% Strk
#24 Louisville15-60.71411-22-45-4+4.50.556W1
Notre Dame11-110.5008-42-52-7+7.50.222L2

Notre Dame & Louisville Futures Odds

Latest College Basketball Championship odds, if available, for each team. Review March Madness odds for other teams and learn how to bet on the college basketball tournament. Also be sure to read Ron Halfback's Final Four write-up.

Notre Dame Championship Odds
2025-26 Notre Dame NCAA Men's Basketball Tournament Odds

Team
OH,US ncaabb Evnum: 1 Odds Pending
Louisville Championship Odds
2025-26 Louisville NCAA Men's Basketball Tournament Odds

Team
OH,US ncaabb Evnum: 1 Odds Pending

Notre Dame & Louisville Team Pages

Review each team's futures odds, betting bonuses, current standings and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Notre Dame vs Louisville College Basketball Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, February 4th, 2026 at 7:00 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's College Basketball page, look for the Notre Dame vs Louisville Game.

    Navigate to the sportsbook's College Basketball page. Next, look for live or upcoming matchups. Select the Notre Dame vs Louisville Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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