Santa Clara vs San Francisco Basketball Odds

The Broncos will play the Dons on Saturday, February 21st, 2026. Your timezone's tip off time is 10:00 pm EST. Check local listings or your nearest streaming app for coverage.

Review our College Basketball Betting guide to learn how to bet this game.

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Matchup Stats
Moneyline Mage
Best Odds
Interactive Odds Example
Prop Bets
Team Standings
Futures Odds
Team Pages
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Key Matchup Stats

Looking into the second half of the 2025-26 college basketball season, Santa Clara and San Francisco are set to hit the hardwood on Saturday, February 21st, 2026. Luckily, we have some clear performance trends emerging now that each team has more than a dozen games under their belts. Use the following data to help analyze this matchup and to place an intelligent wager on its ultimate outcome.

SportsBetting3.com Power Rankings - With the 2025-26 season in full stride, Santa Clara currently has a 97.67 conference power ranking, while the SportsBetting3.com conference power ranking for San Francisco is 95.67.
Away Santa Clara - Santa Clara starts this game with a 7-2 record as an away team, ranking them 2nd in the WCC Conference for away team wins.
Home San Francisco - San Francisco meets Santa Clara boasting a 10-5 record as a home team. They currently rank 5th in the WCC Conference for home team wins.
Conference Win Percentage - Santa Clara currently ranks 2nd (0.867) in the WCC Conference, with San Francisco now standing 5th (0.438) for their conference win percentage in the 2025 WCC Conference for the 2025-26 college basketball season.
Overall Win Percentage - Santa Clara has a 0.786 overall win percentage, with San Francisco matching up with a 0.517 overall win percentage.
Team Records - Santa Clara currently possesses 22-6 regular season overall record. Meanwhile, San Francisco has tallied a 15-14 standing as the 2025-26 college basketball season continues to unfold.

Moneyline Mage

Spelling out the winners with humor since the middle ages.

Hocus pocus, Santa Clara is 22-6, San Francisco is 15-14 overall.

Conference record crucial for tournament seeds, Santa Clara 13-2, San Francisco 7-9.

Santa Clara on a losing streak, San Francisco also lost their last game. Review the tables below to find the best point spread, total, and moneylines for this game. You can bet on college basketball legally at BetRivers and BetMGM. We've also listed each team's futures odds and current standings below.

Best Broncos at Dons Odds

**Best Point Spread Betting Odds**
Underdog San Francisco	Favorite Santa Clara
+6.5 -105 BetMGM Bet	-6.5 -115 BetMGM Bet

Santa Clara has a -6.5 -115 point spread at BetMGM OH. They are the point spread favorite in this matchup. San Francisco has a +6.5 -105 point spread at BetMGM OH. San Francisco is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

**Best Total Betting Odds**
Over	Under
159.5 o -110 BetMGM Bet	159.5 u -110 BetMGM Bet

BetMGM has the best over line of 159.5 points. Risk $110 to win $100. BetMGM has the best under line of 159.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

**Best Moneyline Betting Odds**
Underdog San Francisco	Favorite Santa Clara
+240 BetMGM Bet	-300 BetMGM Bet

Santa Clara is the -300 moneyline favorite. Risk $300 to win $100 on Santa Clara at BetMGM. San Francisco is the +240 underdog at BetMGM. Risk $100 to win $240 on San Francisco. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Santa Clara vs San Francisco College Basketball game on Saturday, February 21st, 2026?

Santa Clara is a -6.5 -115 point spread favorite at BetMGM, while San Francisco is a +6.5 -105 point spread underdog at BetMGM.

What is the over-under total line for the Santa Clara vs San Francisco College Basketball game on Saturday, February 21st, 2026?

The best over line is 159.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 159.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Santa Clara vs San Francisco College Basketball game on Saturday, February 21st, 2026?

Santa Clara is a -300 moneyline favorite at BetMGM and San Francisco is a +240 moneyline underdog at BetMGM.

College Basketball Odds Example

College Basketball Odds and Outcomes Explained
Game	BetMGM Bet
Santa Clara San Francisco 2/21/26 10:00pm EST	-6.5 -115 +6.5 -105

Bet $100 at BetMGM Ohio
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Underdog San Francisco - San Francisco bettors risk $100 to win $95.24 at -105 odds.

A +6.5 San Francisco underdog bet wins if they lose by 6 or fewer, tie, or win outright. Your bet loses if they lose by 7 or more.

Favorite Santa Clara - Santa Clara bettors risk $100 to win $86.96 at -115 odds.

A -6.5 Santa Clara favorite bet wins if they win by 7 or more. Your bet loses if they win by 6 or fewer, tie, or lose outright.

Santa Clara at San Francisco Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Basketball Prop Bets
+ Displays more odds
	BetMGM Bet
Santa Clara San Francisco First to 5 Points 2/21/26 10:00pm EST	-145 +105 Bet
Santa Clara San Francisco First to 10 Points 2/21/26 10:00pm EST	-165 +120 Bet
Santa Clara San Francisco First to 15 Points 2/21/26 10:00pm EST	-185 +130 Bet
Santa Clara San Francisco Game to Overtime 2/21/26 10:00pm EST	Yes +900 No -5000 Bet

Team Standings

2025-2026 College Basketball Regular Season Standings - Santa Clara, San Francisco
Team	W-L	Win%	Home	Away	Conf	CGB	Conf%	Strk
Santa Clara	26-9	0.743	14-1	8-3	15-3	+1	0.833	L2
San Francisco	17-16	0.515	10-6	4-7	8-10	+8	0.444	L1

Santa Clara & San Francisco Futures Odds

Latest College Basketball Championship odds, if available, for each team. Review March Madness odds for other teams and learn how to bet on the college basketball tournament. Also be sure to read Ron Halfback's Final Four write-up.

Santa Clara Championship Odds

No NCAA Men's Basketball Tournament TM Santa Clara YR: futures available

San Francisco Championship Odds

No NCAA Men's Basketball Tournament TM San Francisco YR: futures available

Santa Clara & San Francisco Team Pages

Review each team's futures odds, betting bonuses, current standings and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Santa Clara vs San Francisco College Basketball Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, February 21st, 2026 at 10:00 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Basketball page, look for the Santa Clara vs San Francisco Game.
Navigate to the sportsbook's College Basketball page. Next, look for live or upcoming matchups. Select the Santa Clara vs San Francisco Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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