SMU vs Louisville Basketball Odds

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The Mustangs will play the Cardinals on Wednesday, March 11th, 2026. Your timezone's tip off time is 2:30 pm EDT. Check local listings or your nearest streaming app for coverage.

Review our College Basketball Betting guide to learn how to bet this game.


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Key Matchup Stats

The 2025-26 college basketball postseason has arrived. With tournament action on the docket, SMU and Louisville are set to tip-off on Wednesday, March 11th, 2026. Here's your chance to partake in March Madness! The end of the regular season has left us with solid trends for each team. Use the following performance insights and stats to handicap what promises to be an exciting matchup.

  • SportsBetting3.com Power Rankings - SMU wound up with a 95.00 SportsBetting3.com conference power ranking for the 2025-26 college basketball regular season, while Louisville finished with a 97.00 power ranking.
  • Away Records - Tournament games are typically played at neutral venues, which means both teams are away from their home courts. SMU comes to this matchup with a 3-8 record as an away team, ranking them 6th in the ACC Conference for away team wins. Their opponent, Louisville, finished the regular season with a 4-7 record as an away team, ranking them 5th in the ACC Conference for away team wins.
  • Conference Win Percentage - SMU finished 8th (0.444) in the ACC Conference, with Louisville ending up 5th (0.611) for their conference win percentage in the 2025 ACC Conference.
  • Overall Win Percentage - SMU had a 0.625 regular season overall win percentage, with Louisville notching a 0.710 overall win percentage at the end of the 2025-26 regular season.
  • Team Records - SMU tallied a 20-12 regular season overall record. Meanwhile, Louisville put together a 22-9 standing for 2025-26 college basketball regular season.

Moneyline Mage

Spelling out the winners with humor since the middle ages.

Moneyline Mage
Moneyline Mage

Hocus pocus, SMU faces Louisville in a March Madness showdown on Wednesday.

SMU 20-12 overall, Louisville 22-9 overall, who will advance in single-elimination tournament?

SMU 8-10 ACC, Louisville 11-7 ACC, magic will decide fate on the court.

The tables below have the best point spread lines, total lines, and moneylines for this matchup. Bet on March Madness games at BetRivers and BetMGM. Review this matchup's prop bets below.

Best Mustangs at Cardinals Odds


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SMU at Louisville Prop Bets

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3/11/26 2:30pm EDT
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Team Standings

2025-2026 College Basketball Regular Season Standings - SMU, Louisville
Team W-L Win% Home Away Conf CGB Conf% Strk
#23 Louisville24-110.68615-24-711-7+60.611L1
SMU20-140.58815-33-88-10+90.444L2

SMU & Louisville Futures Odds

Latest College Basketball Championship odds, if available, for each team. Review March Madness odds for other teams and learn how to bet on the college basketball tournament. Also be sure to read Ron Halfback's Final Four write-up.

SMU Championship Odds

No NCAA Men's Basketball Tournament TM SMU YR: futures available

Louisville Championship Odds

No NCAA Men's Basketball Tournament TM Louisville YR: futures available

SMU & Louisville Team Pages

Review each team's futures odds, betting bonuses, current standings and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the SMU vs Louisville College Basketball Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, March 11th, 2026 at 2:30 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's College Basketball page, look for the SMU vs Louisville Game.

    Navigate to the sportsbook's College Basketball page. Next, look for live or upcoming matchups. Select the SMU vs Louisville Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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