The Dukes will play the Cardinals on Friday, September 5th, 2025. The matchup takes place at L&N Federal Credit Union Stadium. Watch this exciting Week 2 matchup at 7:00 pm EDT. Check local listings for coverage on ESPN2.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Matchup Stats
- Paddy O'Parlay
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Key Matchup Stats
The 2025 college football season continues with James Madison matching up against Louisville at L&N Federal Credit Union Stadium. Let's review how each team is doing so far to better understand how this game will play out.
- SportsBetting3.com Power Rankings - James Madison has a 100.00 conference power ranking for the 2025 season so far. The 2025 conference power ranking for Louisville is 99.00.
- Away James Madison - James Madison currently has a 0-0 record as an away team for the 2025 regular season, ranking them 1st in the Sun Belt Conference for away team wins. Not much can be concluded from this stat just yet, so stay tuned.
- Home Louisville - So far, Louisville has a 1-0 record as a home team. They currently rank 1st in the ACC Conference for home team wins in 2025. Keep tabs on this figure, as it will change in the coming weeks.
- Points Scored - James Madison ranks 1st (45) in the Sun Belt Conference, with Louisville currently ranking 3rd (51) for points scored in the 2025 ACC Conference.
- Points Against - James Madison stands 7th (10) in the Sun Belt Conference for points scored by opponents in 2025. Louisville sits at 4th (17) in the 2025 ACC Conference for points against in the 2025 season.
- Team Records - James Madison has a 1-0 regular season overall record, with Louisville currently possessing a 1-0 regular season standing for the 2025 NCAAF season.
Paddy O'Parlay
The "Sports Network" talking heads have nothing on my Irish arse!
Get ready for a wild showdown at L&N Federal Credit Union Stadium on Friday night!
This is a crucial home game for Louisville as they take on James Madison.
Both teams are 1-0 early in the season, so expect a fierce battle on the field.
For more excitement and to review this game's prop bets, head over to SportsBetting3.com. Don't forget to compare the odds below before kickoff!
Best Dukes at Cardinals Odds
| Underdog James Madison | Favorite Louisville |
|---|---|
| Over | Under |
|---|---|
| Underdog James Madison | Favorite Louisville |
|---|---|
Matchup Odds FAQs
Louisville is a -15.5 -110 point spread favorite at BetMGM, while James Madison is a +15.5 -110 point spread underdog at BetMGM.
The best over line is 55.5 -105 points at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 55.5 -115 points at BetMGM, and that means you risk $115 to win $100 betting the under.
Louisville is a -650 moneyline favorite at BetMGM and James Madison is a +475 moneyline underdog at BetMGM.
College Football Odds Example
|
Game |
 BetMGMBet |
|---|---|
James Madison
Louisville
9/05/25 7:00pm EDT | +15.5 -110-15.5 -110 |
Underdog James Madison - James Madison bettors risk $100 to win $90.91 at -110 odds.
A +15.5 James Madison underdog bet wins if they lose by 15 or fewer, tie, or win outright. Your bet loses if they lose by 16 or more.
Favorite Louisville - Louisville bettors risk $100 to win $90.91 at -110 odds.
A -15.5 Louisville favorite bet wins if they win by 16 or more. Your bet loses if they win by 15 or fewer, tie, or lose outright.
James Madison at Louisville Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetMGM Bet |
|
|---|---|
James Madison
Louisville
No Touchdown
To Score 1st Touchdown
9/05/25 7:00pm EDT | +210-325+10000Bet |
James Madison
Louisville
Game to Overtime
9/05/25 7:00pm EDT | Yes +1500No -10000Bet |
James Madison
Louisville
Both Teams Score 10+
9/05/25 7:00pm EDT | Yes -750No +475Bet |
James Madison
Louisville
Both Teams Score 20+
9/05/25 7:00pm EDT | Yes -110No -115Bet |
| BetMGM | |
James Madison
Louisville
Both Teams Score 30+
9/05/25 7:00pm EDT | Yes +475No -750Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 2 | James Madison vs Louisville Friday, September 5th, 2025 | LOU 28, JMU 14 L&N Federal Credit Union Stadium | Louisville by 14 |
| 2022 Week 10 | James Madison vs Louisville Saturday, November 5th, 2022 | LOU 34, JMU 10 Cardinal Stadium | Louisville by 24 |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| ACC | |||||||||
| #16 Louisville | 4-1 | 0.800 | 7 | 1 | 270 | 166 | 4-1 | 3-0 | W3 |
| Sun Belt East | |||||||||
| James Madison | 5-0 | 1.000 | 7 | 1 | 278 | 129 | 4-0 | 3-1 | W6 |
James Madison & Louisville Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
James Madison Championship Odds|
Team | BetMGM |
|---|---|
| James Madison |
|
Team | BetMGM |
|---|---|
| Louisville | +8000 Bet |
James Madison & Louisville Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Weber State vs James Madison | JMU 45, WEB 10 Saturday, August 30th, 2025 |
| Week 2 | James Madison vs Louisville | LOU 28, JMU 14 Friday, September 5th, 2025 |
| Week 4 | James Madison vs Liberty | JMU 31, LIB 13 Saturday, September 20th, 2025 |
| Week 5 | Georgia Southern vs James Madison | JMU 35, GASO 10 Saturday, September 27th, 2025 |
| Week 6 | James Madison vs Georgia State | JMU 14, GAST 7 Saturday, October 4th, 2025 |
| Week 7 | Louisiana vs James Madison | JMU 24, UL 14 Saturday, October 11th, 2025 |
| Week 8 | Old Dominion vs James Madison | JMU 63, ODU 27 Saturday, October 18th, 2025 |
| Week 10 | James Madison vs Texas State | Tuesday, October 28th, 2025 8:00 pm EDT |
| Week 11 | James Madison vs Marshall | Saturday, November 8th, 2025 12:00 am EST |
| Week 12 | Appalachian State vs James Madison | Saturday, November 15th, 2025 12:00 am EST |
| Week 13 | Washington State vs James Madison | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | James Madison vs Coastal Carolina | Saturday, November 29th, 2025 12:00 am EST |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Eastern Kentucky vs Louisville | LOU 51, EKU 17 Saturday, August 30th, 2025 |
| Week 2 | James Madison vs Louisville | LOU 28, JMU 14 Friday, September 5th, 2025 |
| Week 4 | Bowling Green vs Louisville | LOU 40, BGSU 17 Saturday, September 20th, 2025 |
| Week 5 | Louisville vs Pittsburgh | LOU 34, PITT 27 Saturday, September 27th, 2025 |
| Week 6 | Virginia vs Louisville | UVA 30, LOU 27 (OT) Saturday, October 4th, 2025 |
| Week 8 | Louisville vs Miami (FL) | LOU 24, MIA 21 Friday, October 17th, 2025 |
| Week 9 | Boston College vs Louisville | Saturday, October 25th, 2025 7:30 pm EDT |
| Week 10 | Louisville vs Virginia Tech | Saturday, November 1st, 2025 3:00 pm EDT |
| Week 11 | California vs Louisville | Saturday, November 8th, 2025 12:00 am EST |
| Week 12 | Clemson vs Louisville | Friday, November 14th, 2025 7:30 pm EST |
| Week 13 | Louisville vs SMU | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | Kentucky vs Louisville | Saturday, November 29th, 2025 12:00 am EST |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the James Madison vs Louisville College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Friday, September 5th, 2025 at 7:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the James Madison vs Louisville Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the James Madison vs Louisville Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.