USC vs Purdue Football Odds - SportsBetting3.com

The Trojans will play the Boilermakers on Saturday, September 13th, 2025. The matchup takes place at Ross-Ade Stadium. Watch this exciting Week 3 matchup at 5:30 pm EDT. Check local listings for coverage on CBS, Paramount+.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

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Matchup Stats
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Key Matchup Stats

The 2025 college football season continues with USC matching up against Purdue at Ross-Ade Stadium. Let's review how each team is doing so far to better understand how this game will play out.

SportsBetting3.com Power Rankings - USC has a 99.67 conference power ranking for the 2025 season so far. The 2025 conference power ranking for Purdue is 97.00.
Away USC - USC currently has a 0-0 record as an away team for the 2025 regular season, ranking them 2nd in the Big Ten Conference for away team wins. Not much can be concluded from this stat just yet, so stay tuned.
Home Purdue - So far, Purdue has a 2-0 record as a home team. They currently rank 1st in the Big Ten Conference for home team wins in 2025. Keep tabs on this figure, as it will change in the coming weeks.
Points Scored - USC ranks 1st (132) in the Big Ten Conference, with Purdue currently ranking 11th (65) for points scored in the 2025 Big Ten Conference.
Points Against - USC stands 5th (33) in the Big Ten Conference for points scored by opponents in 2025. Purdue sits at 10th (17) in the 2025 Big Ten Conference for points against in the 2025 season.
Team Records - USC has a 2-0 regular season overall record, with Purdue currently possessing a 2-0 regular season standing for the 2025 NCAAF season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Get ready for an epic showdown as USC faces Purdue at Ross-Ade Stadium this Saturday.

Purdue is looking to defend their home turf in this crucial early season matchup.

With both teams boasting a 2-0 record, this game promises to be a nail-biter.

For more excitement, head to SportsBetting3.com to review this game's prop bets and compare the odds below.

Best Trojans at Boilermakers Odds

**Best Point Spread Betting Odds**
Underdog Purdue	Favorite USC
+20.5 -110 BetMGM Bet	-20.5 -110 BetMGM Bet

USC has a -20.5 -110 point spread at BetMGM OH. They are the point spread favorite in this matchup. Purdue has a +20.5 -110 point spread at BetMGM OH. Purdue is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

**Best Total Betting Odds**
Over	Under
59.5 o -110 BetMGM Bet	59.5 u -110 BetMGM Bet

BetMGM has the best over line of 59.5 points. Risk $110 to win $100. BetMGM has the best under line of 59.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

**Best Moneyline Betting Odds**
Underdog Purdue	Favorite USC
+850 BetMGM Bet	-1600 BetMGM Bet

USC is the -1600 moneyline favorite. Risk $1,600 to win $100 on USC at BetMGM. Purdue is the +850 underdog at BetMGM. Risk $100 to win $850 on Purdue. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the USC vs Purdue College Football game on Saturday, September 13th, 2025?

USC is a -20.5 -110 point spread favorite at BetMGM, while Purdue is a +20.5 -110 point spread underdog at BetMGM.

What is the over-under total line for the USC vs Purdue College Football game on Saturday, September 13th, 2025?

The best over line is 59.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 59.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the USC vs Purdue College Football game on Saturday, September 13th, 2025?

USC is a -1600 moneyline favorite at BetMGM and Purdue is a +850 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained
Game	BetMGM Bet
USC Purdue 9/13/25 5:30pm EDT	-20.5 -110 +20.5 -110

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Underdog Purdue - Purdue bettors risk $100 to win $90.91 at -110 odds.

A +20.5 Purdue underdog bet wins if they lose by 20 or fewer, tie, or win outright. Your bet loses if they lose by 21 or more.

Favorite USC - USC bettors risk $100 to win $90.91 at -110 odds.

A -20.5 USC favorite bet wins if they win by 21 or more. Your bet loses if they win by 20 or fewer, tie, or lose outright.

USC at Purdue Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
	BetMGM Bet
USC Purdue 9/13/25 5:30pm EDT	Pending BetMGM

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 3	USC vs Purdue Saturday, September 13th, 2025	USC 33, PUR 17 Ross-Ade Stadium	USC by 16

Team Standings

2025-2026 College Football Regular Season Standings - USC, Purdue
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
USC	3-1	0.750	5	2	297	162	4-0	1-2	L1
Purdue	0-4	0.000	2	5	159	195	2-2	0-3	L5

USC & Purdue Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

USC Championship Odds

2025-26 USC NCAA College Football Championship Odds
Team	BetMGM
USC	+8000 Bet

Purdue Championship Odds

No NCAA College Football Championship TM Purdue YR: futures available

USC & Purdue Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2025-26 USC Games & Results
Week	Matchup	Date & Result
Week 1	Missouri State vs USC	USC 73, MOST 13 Saturday, August 30th, 2025
Week 2	Georgia Southern vs USC	USC 59, GASO 20 Saturday, September 6th, 2025
Week 3	USC vs Purdue	USC 33, PUR 17 Saturday, September 13th, 2025
Week 4	Michigan State vs USC	USC 45, MSU 31 Saturday, September 20th, 2025
Week 5	USC vs Illinois	ILL 34, USC 32 Saturday, September 27th, 2025
Week 7	Michigan vs USC	USC 31, MICH 13 Saturday, October 11th, 2025
Week 8	USC vs Notre Dame	ND 34, USC 24 Saturday, October 18th, 2025
Week 10	USC vs Nebraska	Saturday, November 1st, 2025 7:30 pm EDT
Week 11	Northwestern vs USC	Friday, November 7th, 2025 9:00 pm EST
Week 12	Iowa vs USC	Saturday, November 15th, 2025 12:00 am EST
Week 13	USC vs Oregon	Saturday, November 22nd, 2025 12:00 am EST
Week 14	UCLA vs USC	Saturday, November 29th, 2025 12:00 am EST

2025-26 Purdue Games & Results
Week	Matchup	Date & Result
Week 1	Ball State vs Purdue	PUR 31, BALL 0 Saturday, August 30th, 2025
Week 2	Southern Illinois vs Purdue	PUR 34, SIU 17 Saturday, September 6th, 2025
Week 3	USC vs Purdue	USC 33, PUR 17 Saturday, September 13th, 2025
Week 4	Purdue vs Notre Dame	ND 56, PUR 30 Saturday, September 20th, 2025
Week 6	Illinois vs Purdue	ILL 43, PUR 27 Saturday, October 4th, 2025
Week 7	Purdue vs Minnesota	MINN 27, PUR 20 Saturday, October 11th, 2025
Week 8	Purdue vs Northwestern	NU 19, PUR 0 Saturday, October 18th, 2025
Week 9	Rutgers vs Purdue	Saturday, October 25th, 2025 12:00 pm EDT
Week 10	Purdue vs Michigan	Saturday, November 1st, 2025 7:00 pm EDT
Week 11	Ohio State vs Purdue	Saturday, November 8th, 2025 12:00 am EST
Week 12	Purdue vs Washington	Saturday, November 15th, 2025 12:00 am EST
Week 14	Indiana vs Purdue	Friday, November 28th, 2025 7:30 pm EST

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the USC vs Purdue College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 13th, 2025 at 5:30 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the USC vs Purdue Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the USC vs Purdue Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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