The Bills will play the Colts on Sunday, November 10th, 2024. The matchup takes place at Lucas Oil Stadium. Watch this exciting Week 10 matchup at 1:03 pm EST. Check local listings for coverage on CBS.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

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Key Matchup Stats

Rolling into Week 10, the Buffalo Bills and Indianapolis Colts will matchup on Sunday, November 10th, 2024 at Lucas Oil Stadium for an important mid-season game. We've compiled some key performance stats below to help you handicap this matchup. Now that the 2024-25 NFL regular season is half over, teams need to sharpen their performance with an eye for the January playoffs.

SportsBetting3.com Power Rankings - As of Week 10 of the 2024-25 season, the Buffalo Bills have a power ranking of 98.33. Our formula has the Indianapolis Colts at a 89.67 power ranking.
Away Buffalo Bills - With the season now half over, the Buffalo Bills have a 3-2-0 record as an away team, ranking them 2nd in the league for away team wins.
Home Indianapolis Colts - The Indianapolis Colts start this Week 10 matchup with a 3-1-0 record as a home team. They rank 2nd in the league for home team wins so far in the 2024-25 regular season.
Points Scored - The Buffalo Bills currently rank 3rd (260) looking at Week 10, with the Indianapolis Colts ranked 15th (188) for points scored to date.
Points Against - The Buffalo Bills stand 21st (173) now halfway through the regular season for points against. Meanwhile the Indianapolis Colts currently rank 16th (193) for points against.
Team Records - The second half of the season is make or break. Heading into Week 10, the Buffalo Bills have a 7-2-0 record, with the Indianapolis Colts at 4-5-0 for the 2024-25 regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Avast, ye landlubbers! The Buffalo Bills be clashin' with the Indianapolis Colts on Sunday. The NFL season be half done, and every win be crucial for playoff hopes. The Bills be standin' at 7-2-0, while the Colts be laggin' at 4-5-0.

The Week 10 showdown be happenin' at Lucas Oil Stadium, a fine venue indeed. The city o' Indianapolis be steeped in football culture, aye, full o' loyal fans. The clash be sure to be fierce as these two teams battle for victory.

According to SportsBetting3.com, the Bills be rankin' at 98.33 and the Colts at 89.67. I recommend bettin' on this game at BetRivers, or BetMGM. Review this matchup's prop bets below, and look at the odds from our partner sportsbooks. Arrr!

Best Bills at Colts Odds

**Best Point Spread Betting Odds**
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**Best Total Betting Odds**
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**Best Moneyline Betting Odds**
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NFL Odds Example

NFL Odds and Outcomes Explained
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Buffalo Bills at Indianapolis Colts Prop Bets

NFL Prop Bets
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Bills Colts 11/10/24 1:03pm EST	Pending

Recent Meetings Since 2020

Recent Meetings Since 2020
Week	Game	Result	Margin
2024 Week 10	Bills vs Colts Sunday, November 10th, 2024	BUF 30, IND 20 Lucas Oil Stadium	Bills by 10
2023 Preseason Week 1	Colts vs Bills Saturday, August 12th, 2023	BUF 23, IND 19 Highmark Stadium	Bills by 4
2022 Preseason Week 1	Colts vs Bills Saturday, August 13th, 2022	BUF 27, IND 24 Highmark Stadium	Bills by 3
2021 Week 11	Colts vs Bills Sunday, November 21st, 2021	IND 41, BUF 15 Highmark Stadium	Colts by 26
2020 Wild Card	Colts vs Bills Saturday, January 9th, 2021 AFC Wild Card Playoffs	BUF 27, IND 24 Highmark Stadium	Bills by 3

Team Standings

2024-2025 NFL Regular Season Standings - Buffalo Bills, Indianapolis Colts
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xz - Buffalo Bills	13	4	0	0.765	525	368	8-0-0	5-4-0	5-1-0	0.833	9-3-0	0.750	1L	3-2-0
Indianapolis Colts	8	9	0	0.471	377	427	5-3-0	3-6-0	3-3-0	0.500	7-5-0	0.583	1W	3-2-0

Buffalo Bills & Indianapolis Colts Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Buffalo Bills Futures Odds

No Super Bowl TM Buffalo Bills YR: futures available

Indianapolis Colts Futures Odds

No Super Bowl TM Indianapolis Colts YR: futures available

Buffalo Bills & Indianapolis Colts Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Buffalo Bills vs Indianapolis Colts NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, November 10th, 2024 at 1:03 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the Buffalo Bills vs Indianapolis Colts Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Buffalo Bills vs Indianapolis Colts Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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