Buffalo Bills vs Indianapolis Colts Odds

The Bills will play the Colts on Sunday, November 10th, 2024. The matchup takes place at Lucas Oil Stadium. Watch this exciting Week 10 matchup at 1:03 pm EST. Check local listings for coverage on CBS.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.


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Table of Contents

Key Matchup Stats

Rolling into Week 10, the Buffalo Bills and Indianapolis Colts will matchup on Sunday, November 10th, 2024 at Lucas Oil Stadium for an important mid-season game. We've compiled some key performance stats below to help you handicap this matchup. Now that the 2024-25 NFL regular season is half over, teams need to sharpen their performance with an eye for the January playoffs.

  • SportsBetting3.com Power Rankings - As of Week 10 of the 2024-25 season, the Buffalo Bills have a power ranking of 98.33. Our formula has the Indianapolis Colts at a 89.67 power ranking.
  • Away Buffalo Bills - With the season now half over, the Buffalo Bills have a 3-2-0 record as an away team, ranking them 2nd in the league for away team wins.
  • Home Indianapolis Colts - The Indianapolis Colts start this Week 10 matchup with a 3-1-0 record as a home team. They rank 2nd in the league for home team wins so far in the 2024-25 regular season.
  • Points Scored - The Buffalo Bills currently rank 3rd (260) looking at Week 10, with the Indianapolis Colts ranked 15th (188) for points scored to date.
  • Points Against - The Buffalo Bills stand 21st (173) now halfway through the regular season for points against. Meanwhile the Indianapolis Colts currently rank 16th (193) for points against.
  • Team Records - The second half of the season is make or break. Heading into Week 10, the Buffalo Bills have a 7-2-0 record, with the Indianapolis Colts at 4-5-0 for the 2024-25 regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast, ye landlubbers! The Buffalo Bills be clashin' with the Indianapolis Colts on Sunday. The NFL season be half done, and every win be crucial for playoff hopes. The Bills be standin' at 7-2-0, while the Colts be laggin' at 4-5-0.

The Week 10 showdown be happenin' at Lucas Oil Stadium, a fine venue indeed. The city o' Indianapolis be steeped in football culture, aye, full o' loyal fans. The clash be sure to be fierce as these two teams battle for victory.

According to SportsBetting3.com, the Bills be rankin' at 98.33 and the Colts at 89.67. I recommend bettin' on this game at BetRivers, or BetMGM. Review this matchup's prop bets below, and look at the odds from our partner sportsbooks. Arrr!

Best Bills at Colts Odds


Best Point Spread Betting Odds
Underdog

Indianapolis Colts
Favorite

Buffalo Bills
The Buffalo Bills have a -4 -110 point spread at BetRivers PA. They are the point spread favorite in this matchup. The Indianapolis Colts have a +4 -110 point spread at BetRivers PA. The Indianapolis Colts are the point spread underdogs. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetRivers has the best over line of 46.5 points. Risk $110 to win $100. BetRivers has the best under line of 46.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

Indianapolis Colts
Favorite

Buffalo Bills
The Buffalo Bills are the -200 moneyline favorite. Risk $200 to win $100 on the Buffalo Bills at BetRivers. The Indianapolis Colts are the +165 underdog at BetRivers. Risk $100 to win $165 on the Indianapolis Colts. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Buffalo Bills vs Indianapolis Colts NFL game on Sunday, November 10th, 2024?

The Buffalo Bills are -4 -110 point spread favorites at BetRivers, while the Indianapolis Colts are +4 -110 point spread underdogs at BetRivers.

What is the over-under total line for the Buffalo Bills vs Indianapolis Colts NFL game on Sunday, November 10th, 2024?

The best over line is 46.5 -110 points at BetRivers, which means you risk $110 to win $100 betting the over. The best under line is 46.5 -110 points at BetRivers, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Buffalo Bills vs Indianapolis Colts NFL game on Sunday, November 10th, 2024?

The Buffalo Bills are the -200 moneyline favorite at BetRivers and the Indianapolis Colts are the +165 moneyline underdog at BetRivers.

NFL Odds Example

NFL Odds and Outcomes Explained

Game
BetRivers Sports Betting BetRivers
Bet
Bills
Colts
11/10/24 1:03pm EST
-4 -110+4 -110
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Underdog Indianapolis Colts - Indianapolis Colts bettors risk $100 to win $90.91 at -110 odds.

A +4 Indianapolis Colts underdog bet wins if they lose by 3 or fewer, tie, or win outright. The bet pushes if they lose by 4. Your bet loses if they lose by 5 or more.

Favorite Buffalo Bills - Buffalo Bills bettors risk $100 to win $90.91 at -110 odds.

A -4 Buffalo Bills favorite bet wins if they win by 5 or more. The bet pushes if they win by 4. Your bet loses if they win by 3 or fewer, tie, or lose outright.

Buffalo Bills at Indianapolis Colts Prop Bets

NFL Prop Bets
+ Displays more odds
BetRivers Sports Betting BetRivers
Bet
Bills
Colts
Tie
First to 15 Points
11/10/24 1:03pm EST
-182+140+2400Bet
Bills
Colts
Tie
First to 20 Points
11/10/24 1:03pm EST
-159+170+700Bet
Bills
Colts
Safety to be Scored
11/10/24 1:03pm EST
Yes +2000No -10000Bet
Bills
Team Total Points
BUF at IND
11/10/24 1:03pm EST
24.5 o -11024.5 u -110Bet
BetRivers Sports Betting BetRivers
Colts
Team Total Points
BUF at IND
11/10/24 1:03pm EST
20.5 o -11320.5 u -108Bet

Recent Meetings Since 2020

Recent Meetings Since 2020
WeekGameResultMargin
2024
Week 10
Bills vs Colts
Sunday, November 10th, 2024
BUF 30, IND 20
Lucas Oil Stadium
Bills by 10
2023
Preseason Week 1
Colts vs Bills
Saturday, August 12th, 2023
BUF 23, IND 19
Highmark Stadium
Bills by 4
2022
Preseason Week 1
Colts vs Bills
Saturday, August 13th, 2022
BUF 27, IND 24
Highmark Stadium
Bills by 3
2021
Week 11
Colts vs Bills
Sunday, November 21st, 2021
IND 41, BUF 15
Highmark Stadium
Colts by 26
2020
Wild Card
Colts vs Bills
Saturday, January 9th, 2021
AFC Wild Card Playoffs
BUF 27, IND 24
Highmark Stadium
Bills by 3

Team Standings

2024-2025 NFL Regular Season Standings - Buffalo Bills, Indianapolis Colts
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
xz - Buffalo Bills13400.7655253688-0-05-4-05-1-00.8339-3-00.7501L3-2-0
Indianapolis Colts8900.4713774275-3-03-6-03-3-00.5007-5-00.5831W3-2-0

Buffalo Bills & Indianapolis Colts Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Buffalo Bills Futures Odds
2026-27 Buffalo Bills Super Bowl Odds

Team
BetRivers Sports Betting BetRivers
Bills
+1000
Bet
Indianapolis Colts Futures Odds
2026-27 Indianapolis Colts Super Bowl Odds

Team
BetRivers Sports Betting BetRivers
Colts
+5000
Bet

Buffalo Bills & Indianapolis Colts Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Buffalo Bills vs Indianapolis Colts NFL Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Sunday, November 10th, 2024 at 1:03 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's NFL page, look for the Buffalo Bills vs Indianapolis Colts Game.

    Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Buffalo Bills vs Indianapolis Colts Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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