The 49ers will play the Buccaneers on Sunday, October 12th, 2025. The matchup takes place at Raymond James Stadium. Watch this exciting Week 6 matchup at 4:25 pm EDT. Check local listings for coverage on CBS.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The San Francisco 49ers and Tampa Bay Buccaneers will take the field at Raymond James Stadium for a key Week 6 matchup on Sunday, October 12th, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.
- SportsBetting3.com Power Rankings - Heading into Week 6 of the 2025-26 season, the San Francisco 49ers have a power ranking of 95.67. Our calculations have the Tampa Bay Buccaneers at a 95.00 power ranking.
- Away San Francisco 49ers - Now in the middle of the season, the San Francisco 49ers have a 3-0-0 record as an away team, ranking them 1st in the league for away team wins.
- Home Tampa Bay Buccaneers - The Tampa Bay Buccaneers come to this Week 6 matchup with a 1-1-0 record as a home team. They rank 3rd in the league for home team wins so far this season.
- Points Scored - The San Francisco 49ers currently rank 15th (106) on the edge of Week 6, with the Tampa Bay Buccaneers ranked 7th (135) for points scored to date.
- Points Against - The San Francisco 49ers stand 20th (98) in the middle weeks of the regular season for points against. As for the Tampa Bay Buccaneers, they currently rank 9th (132) for points against.
- Team Records - Standings become more important now more than ever. Approaching Week 6, the San Francisco 49ers have a 4-1-0 record, with the Tampa Bay Buccaneers at 4-1-0 for the 2025-26 regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scallywags! The San Francisco 49ers be facing the Tampa Bay Buccaneers on Sunday!
Both teams be standin' at 4-1-0, makin' this a crucial Week 6 match!
The battle be happenin' at Raymond James Stadium, known for its lively city and culture.
Bet this game at BetMGM or our preferred sports betting partner BetRivers, look at this game's prop bets, and compare odds from partner sports betting sites.
Best 49ers at Buccaneers Odds
| Underdog San Francisco 49ers | Favorite Tampa Bay Buccaneers |
|---|---|
| Over | Under |
|---|---|
| Underdog San Francisco 49ers | Favorite Tampa Bay Buccaneers |
|---|---|
Matchup Odds FAQs
The Tampa Bay Buccaneers are -3.5 -105 point spread favorites at BetMGM, while the San Francisco 49ers are +3.5 -115 point spread underdogs at BetMGM.
The best over line is 47 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 47 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The Tampa Bay Buccaneers are the -185 moneyline favorite at BetMGM and the San Francisco 49ers are the +150 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
49ers
Buccaneers
10/12/25 4:25pm EDT | +3.5 -115-3.5 -105 |
Underdog San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $86.96 at -115 odds.
A +3.5 San Francisco 49ers underdog bet wins if they lose by 3 or fewer, tie, or win outright. Your bet loses if they lose by 4 or more.
Favorite Tampa Bay Buccaneers - Tampa Bay Buccaneers bettors risk $100 to win $95.24 at -105 odds.
A -3.5 Tampa Bay Buccaneers favorite bet wins if they win by 4 or more. Your bet loses if they win by 3 or fewer, tie, or lose outright.
San Francisco 49ers at Tampa Bay Buccaneers Prop Bets
| BetMGM Bet |
|
|---|---|
49ers
Buccaneers
First Team To Score
10/12/25 4:25pm EDT | +100-130Bet |
49ers
Buccaneers
No Touchdown
To Score 1st Touchdown
10/12/25 4:25pm EDT | +110-150+10000Bet |
49ers
Buccaneers
Game to Overtime
10/12/25 4:25pm EDT | Yes +700No -2000Bet |
49ers
Buccaneers
Safety to be Scored
10/12/25 4:25pm EDT | Yes +1000No -3000Bet |
| BetMGM | |
Baker Mayfield
Interceptions Thrown
SF at TB 10/12/25 4:25pm EDT | 0.5 o -1050.5 u -125Bet |
Mac Jones
Interceptions Thrown
SF at TB 10/12/25 4:25pm EDT | 0.5 o -1400.5 u +105Bet |
Baker Mayfield
Longest Passing Completion
SF at TB 10/12/25 4:25pm EDT | 36.5 o -11836.5 u -110Bet |
Mac Jones
Longest Passing Completion
SF at TB 10/12/25 4:25pm EDT | 33.5 o -12033.5 u -110Bet |
| BetMGM | |
Chase McLaughlin
Total Kicking Points
SF at TB 10/12/25 4:25pm EDT | 7.5 o -1107.5 u -120Bet |
Eddy Pineiro
Total Kicking Points
SF at TB 10/12/25 4:25pm EDT | 6.5 o -1506.5 u +110Bet |
Baker Mayfield
Total Pass Completions
SF at TB 10/12/25 4:25pm EDT | 23.5 o -10523.5 u -130Bet |
Mac Jones
Total Pass Completions
SF at TB 10/12/25 4:25pm EDT | 24.5 o -11524.5 u -118Bet |
| BetMGM | |
Baker Mayfield
Total Passing Yards
SF at TB 10/12/25 4:25pm EDT | 245.5 o -115245.5 u -115Bet |
Mac Jones
Total Passing Yards
SF at TB 10/12/25 4:25pm EDT | 250.5 o -115250.5 u -115Bet |
Baker Mayfield
Total Touchdown Passes
SF at TB 10/12/25 4:25pm EDT | 1.5 o -1651.5 u +125Bet |
Mac Jones
Total Touchdown Passes
SF at TB 10/12/25 4:25pm EDT | 1.5 o +1051.5 u -140Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 6 | 49ers vs Buccaneers Sunday, October 12th, 2025 | TB 30, SF 19 Raymond James Stadium | Buccaneers by 11 |
| 2024 Week 10 | 49ers vs Buccaneers Sunday, November 10th, 2024 | SF 23, TB 20 Raymond James Stadium | 49ers by 3 |
| 2023 Week 11 | Buccaneers vs 49ers Sunday, November 19th, 2023 | SF 27, TB 14 Levi's Stadium | 49ers by 13 |
| 2022 Week 14 | Buccaneers vs 49ers Sunday, December 11th, 2022 | SF 35, TB 7 Levi's Stadium | 49ers by 28 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tampa Bay Buccaneers | 6 | 2 | 0 | 0.750 | 197 | 178 | 2-1-0 | 4-1-0 | 2-0-0 | 1.000 | 4-2-0 | 0.667 | 1W | 3-2-0 |
| San Francisco 49ers | 5 | 3 | 0 | 0.625 | 160 | 164 | 2-1-0 | 3-2-0 | 3-0-0 | 1.000 | 5-1-0 | 0.833 | 1L | 2-3-0 |
San Francisco 49ers & Tampa Bay Buccaneers Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
San Francisco 49ers Futures Odds|
Team | BetMGM |
|---|---|
| 49ers | +3000 Bet |
|
Team | BetMGM |
|---|---|
| Buccaneers | +2500 Bet |
San Francisco 49ers & Tampa Bay Buccaneers Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco 49ers vs Tampa Bay Buccaneers NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, October 12th, 2025 at 4:25 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Tampa Bay Buccaneers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Tampa Bay Buccaneers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other October 12, 2025 NFL Games
- Denver Broncos vs New York Jets - 10/12/25 9:30am EDT
- New England Patriots vs New Orleans Saints - 10/12/25 1:00pm EDT
- Los Angeles Chargers vs Miami Dolphins - 10/12/25 1:00pm EDT
- Seattle Seahawks vs Jacksonville Jaguars - 10/12/25 1:00pm EDT
- Arizona Cardinals vs Indianapolis Colts - 10/12/25 1:00pm EDT
- Los Angeles Rams vs Baltimore Ravens - 10/12/25 1:00pm EDT
- Cleveland Browns vs Pittsburgh Steelers - 10/12/25 1:00pm EDT
- Dallas Cowboys vs Carolina Panthers - 10/12/25 1:03pm EDT
- Tennessee Titans vs Las Vegas Raiders - 10/12/25 4:05pm EDT
- Cincinnati Bengals vs Green Bay Packers - 10/12/25 4:25pm EDT
- Detroit Lions vs Kansas City Chiefs - 10/12/25 8:20pm EDT