The Bills will play the Jaguars on Sunday, November 7th, 2021. The matchup takes place at TIAA Bank Field. Watch this exciting Week 9 matchup at 1:00 pm EST. Check local listings for coverage on CBS.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

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#1 BetMGM REVIEW	New Customers - Up to $1500 Paid Back in Bonus Bets Bonus Bets Expire in 7 Days One new customer offer/Add'l Terms Bet Now 21+ Playable in Ohio only Gambling Problem? Call 1-800-589-9966

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Best Bills at Jaguars Odds

**Best Point Spread Betting Odds**
TBD	TBD

Point Spread odds are updating, please check back soon.

**Best Total Betting Odds**
Over	Under

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**Best Moneyline Betting Odds**
TBD	TBD

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NFL Odds Example

NFL Odds and Outcomes Explained
Game	Book

Buffalo Bills at Jacksonville Jaguars Prop Bets

NFL Prop Bets
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	BetMGM Bet
Bills Jaguars 11/07/21 1:00pm EST	Pending BetMGM

Recent Meetings Since 2017

Recent Meetings Since 2017
Week	Game	Result	Margin
2024 Week 3	Jaguars vs Bills Monday, September 23rd, 2024	BUF 47, JAX 10 Highmark Stadium	Bills by 37
2023 Week 5	Jaguars vs Bills Sunday, October 8th, 2023	JAX 25, BUF 20 Tottenham Hotspur Stadium	Jaguars by 5
2021 Week 9	Bills vs Jaguars Sunday, November 7th, 2021	JAX 9, BUF 6 TIAA Bank Field	Jaguars by 3
2018 Week 12	Jaguars vs Bills Sunday, November 25th, 2018	BUF 24, JAX 21 Highmark Stadium	Bills by 3
2017 Wild Card	Bills vs Jaguars Sunday, January 7th, 2018 AFC Wild Card Playoff	JAX 10, BUF 3 TIAA Bank Field	Jaguars by 7

Team Standings

2021-2022 NFL Regular Season Standings - Buffalo Bills, Jacksonville Jaguars
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xz - Buffalo Bills	11	6	0	0.647	483	289	6-3-0	5-3-0	5-1-0	0.833	7-5-0	0.583	4W	4-1-0
Jacksonville Jaguars	3	14	0	0.176	253	457	3-6-0	0-8-0	1-5-0	0.167	3-9-0	0.250	1W	1-4-0

Buffalo Bills & Jacksonville Jaguars Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Buffalo Bills Futures Odds

2025-26 Buffalo Bills Super Bowl Odds
Team	BetMGM
Bills	+700 Bet

Jacksonville Jaguars Futures Odds

2025-26 Jacksonville Jaguars Super Bowl Odds
Team	BetMGM
Jaguars	+8000 Bet

Buffalo Bills & Jacksonville Jaguars Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Buffalo Bills vs Jacksonville Jaguars NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, November 7th, 2021 at 1:00 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the Buffalo Bills vs Jacksonville Jaguars Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Buffalo Bills vs Jacksonville Jaguars Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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Buffalo Bills vs Jacksonville Jaguars Odds

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