San Francisco 49ers vs Philadelphia Eagles NFL Betting Lines

Odds Preview 360

The 49ers will play the Eagles on Sunday, September 19th, 2021. The matchup takes place at Lincoln Financial Field. Watch this exciting week 2 matchup at 1:00 pm on FOX.

Best Underdog and Favorite Spread Bets
Underdog
Philadelphia Eagles
Philadelphia Eagles
Favorite
San Francisco 49ers
San Francisco 49ers
+3 -110 Sb3gen3 -3 +100 Sb3gen2
+3 -115 Sb3gen1 -3 -105 Sb3gen1
+3 -120 Sb3gen2 -3 -110 Sb3gen3
SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Sunday. Sb3gen2 has the best favorite San Francisco 49ers spread at -3 points. Sb3gen3 has the best underdog Philadelphia Eagles spread at +3 points.

Review our point spread betting tutorial and video for more information.
Best Over and Under Total Lines
OverUnder
49o -108 Sb3gen1 49u -105 Sb3gen2
49o -110 Sb3gen3 49u -110 Sb3gen3
49o -115 Sb3gen2 49u -112 Sb3gen1
The over under line estimates the combined total of each team's final score. Sb3gen1 has the best over line of 49 points laying $108 to win $100. Sb3gen2 has the best under line of 49 u -105.
Best Money Line Bets
Underdog
Philadelphia Eagles
Philadelphia Eagles
Favorite
San Francisco 49ers
San Francisco 49ers
+130 Sb3gen3 -145 Sb3gen2
+127 Sb3gen1 -147 Sb3gen1
+125 Sb3gen2 -150 Sb3gen3
Here are money lines for the outright winner. Favorite San Francisco 49ers has a minus value. Lay $145 at Sb3gen2 to win $100. Underdog Philadelphia Eagles has a positive value. Risk $100 at Sb3gen3 to win $130.

San Francisco 49ers vs Philadelphia Eagles Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

San Francisco 49ers Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
San Francisco 49ersSan Francisco 49ers

Cached 2021-09-21 16:28:27
Philadelphia Eagles Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
Philadelphia EaglesPhiladelphia Eagles

Cached 2021-09-21 16:28:27

Team Stats

2021 San Francisco 49ers Team Stats
Stat San Francisco 49ers Opponents
Total 1st Downs 44 49
Total Offensive Yards 748 758
Total Rushing Yards 248 267
Total Passing Yards 500 491
Sacks 5 1
Field Goals 3 / 4 2 / 4
Touchdowns 7 5
Avg Time Of Possession 30:43 29:16
Turnover Ratio -1

2021 Philadelphia Eagles Team Stats
Stat Philadelphia Eagles Opponents
Total 1st Downs 42 42
Total Offensive Yards 762 566
Total Rushing Yards 324 241
Total Passing Yards 438 325
Sacks 3 3
Field Goals 2 / 3 3 / 3
Touchdowns 5 2
Avg Time Of Possession 28:04 31:56
Turnover Ratio


Team Standings

2021 Regular Season Standings
Team Conf Div W L T Pct Home Road Last 5
Philadelphia EaglesSan Francisco 49ers 2-0-0 0-0-0 2 0 0 1.000 0-0-0 2-0-0 2-0-0
Philadelphia EaglesPhiladelphia Eagles 1-1-0 0-0-0 1 1 0 0.500 0-1-0 1-0-0 1-1-0

2021 San Francisco 49ers Games & Results

Bye Week: 6
WeekMatchupDate & Time
1 49ers vs
Lions
SF 41, DET 33
09/12/2021
2 49ers vs
Eagles
SF 17, PHI 11
09/19/2021
3 Packers vs
49ers
09/26/2021
8:20PM
4 Seahawks vs
49ers
10/03/2021
4:05PM
5 49ers vs
Cardinals
10/10/2021
4:25PM
6San Francisco 49ers ByeN/A
7 Colts vs
49ers
10/24/2021
8:20PM
8 49ers vs
Bears
10/31/2021
1:00PM
9 Cardinals vs
49ers
11/07/2021
4:25PM
10 Rams vs
49ers
11/15/2021
8:15PM
11 49ers vs
Jaguars
11/21/2021
1:00PM
12 Vikings vs
49ers
11/28/2021
4:25PM
13 49ers vs
Seahawks
12/05/2021
8:20PM
14 49ers vs
Bengals
12/12/2021
1:00PM
15 Falcons vs
49ers
12/19/2021
4:05PM
16 49ers vs
Titans
12/23/2021
8:20PM
17 Texans vs
49ers
01/02/2022
4:05PM

2021 Philadelphia Eagles Games & Results

Bye Week: 14
WeekMatchupDate & Time
1 Eagles vs
Falcons
PHI 32, ATL 6
09/12/2021
2 49ers vs
Eagles
SF 17, PHI 11
09/19/2021
3 Eagles vs
Cowboys
09/27/2021
8:15PM
4 Chiefs vs
Eagles
10/03/2021
1:00PM
5 Eagles vs
Panthers
10/10/2021
1:00PM
6 Buccaneers vs
Eagles
10/14/2021
8:20PM
7 Eagles vs
Raiders
10/24/2021
4:05PM
8 Eagles vs
Lions
10/31/2021
1:00PM
9 Chargers vs
Eagles
11/07/2021
4:05PM
10 Eagles vs
Broncos
11/14/2021
4:25PM
11 Saints vs
Eagles
11/21/2021
1:00PM
12 Eagles vs
Giants
11/28/2021
1:00PM
13 Eagles vs
Jets
12/05/2021
1:00PM
14Philadelphia Eagles ByeN/A
15 TBD vs
Eagles
TBD
12/19/2021
16 Giants vs
Eagles
12/26/2021
1:00PM
17 Eagles vs
TBD
01/02/2022
1:00PM

Other 2021 Week 2 Matchups

MatchupDate & Time
Giants vs
TBD
WSH 30, NYG 29
09/16/2021
Bengals vs
Bears
CHI 20, CIN 17
09/19/2021
Texans vs
Browns
CLE 31, HOU 21
09/19/2021
Rams vs
Colts
LAR 27, IND 24
09/19/2021
Bills vs
Dolphins
BUF 35, MIA 0
09/19/2021
Patriots vs
Jets
NE 25, NYJ 6
09/19/2021
49ers vs
Eagles
SF 17, PHI 11
09/19/2021
Raiders vs
Steelers
LV 26, PIT 17
09/19/2021
Saints vs
Panthers
CAR 26, NO 7
09/19/2021
Broncos vs
Jaguars
DEN 23, JAX 13
09/19/2021
Vikings vs
Cardinals
ARI 34, MIN 33
09/19/2021
Falcons vs
Buccaneers
TB 48, ATL 25
09/19/2021
Cowboys vs
Chargers
DAL 20, LAC 17
09/19/2021
Titans vs
Seahawks
TEN 33, SEA 30 (OT)
09/19/2021
Chiefs vs
Ravens
BAL 36, KC 35
09/19/2021
Lions vs
Packers
GB 35, DET 17
09/20/2021

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