San Francisco 49ers vs Philadelphia Eagles NFL Betting Lines

Odds Preview 360

The 49ers will play the Eagles on Sunday, September 19th, 2021. The matchup takes place at Lincoln Financial Field. Watch this exciting week 2 matchup at 1:00 pm on FOX.

Best Underdog and Favorite Spread Bets

Underdog Philadelphia Eagles	Favorite San Francisco 49ers
+3 -110 Sb3gen3	-3 +100 Sb3gen2
+3 -115 Sb3gen1	-3 -105 Sb3gen1
+3 -120 Sb3gen2	-3 -110 Sb3gen3

SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Sunday. Sb3gen2 has the best favorite San Francisco 49ers spread at -3 points. Sb3gen3 has the best underdog Philadelphia Eagles spread at +3 points.

Review our point spread betting tutorial and video for more information.

Best Over and Under Total Lines

Over	Under
49o -108 Sb3gen1	49u -105 Sb3gen2
49o -110 Sb3gen3	49u -110 Sb3gen3
49o -115 Sb3gen2	49u -112 Sb3gen1

The over under line estimates the combined total of each team's final score. Sb3gen1 has the best over line of 49 points laying $108 to win $100. Sb3gen2 has the best under line of 49 u -105.

Best Money Line Bets

Underdog Philadelphia Eagles	Favorite San Francisco 49ers
+130 Sb3gen3	-145 Sb3gen2
+127 Sb3gen1	-147 Sb3gen1
+125 Sb3gen2	-150 Sb3gen3

Here are money lines for the outright winner. Favorite San Francisco 49ers has a minus value. Lay $145 at Sb3gen2 to win $100. Underdog Philadelphia Eagles has a positive value. Risk $100 at Sb3gen3 to win $130.

San Francisco 49ers vs Philadelphia Eagles Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

San Francisco 49ers Super Bowl Odds

Super Bowl 2022 Futures Odds

Outcome	SB3Gen
San Francisco 49ers	+1100

Cached 2021-09-21 16:28:27
Philadelphia Eagles Super Bowl Odds

Super Bowl 2022 Futures Odds

Outcome	SB3Gen
Philadelphia Eagles	+6600

Cached 2021-09-21 16:28:27

Team Stats

2021 San Francisco 49ers Team Stats

Stat	San Francisco 49ers	Opponents
Total 1st Downs	44	49
Total Offensive Yards	748	758
Total Rushing Yards	248	267
Total Passing Yards	500	491
Sacks	5	1
Field Goals	3 / 4	2 / 4
Touchdowns	7	5
Avg Time Of Possession	30:43	29:16
Turnover Ratio	-1

2021 Philadelphia Eagles Team Stats

Stat	Philadelphia Eagles	Opponents
Total 1st Downs	42	42
Total Offensive Yards	762	566
Total Rushing Yards	324	241
Total Passing Yards	438	325
Sacks	3	3
Field Goals	2 / 3	3 / 3
Touchdowns	5	2
Avg Time Of Possession	28:04	31:56
Turnover Ratio

Team Standings

2021 Regular Season Standings

Team	Conf	Div	W	L	T	Pct	Home	Road	Last 5
San Francisco 49ers	2-0-0	0-0-0	2	0	0	1.000	0-0-0	2-0-0	2-0-0
Philadelphia Eagles	1-1-0	0-0-0	1	1	0	0.500	0-1-0	1-0-0	1-1-0

2021 San Francisco 49ers Games & Results

Bye Week: 6

Week	Matchup	Date & Time
1	49ers vs Lions	SF 41, DET 33 09/12/2021
2	49ers vs Eagles	SF 17, PHI 11 09/19/2021
3	Packers vs 49ers	09/26/2021 8:20PM
4	Seahawks vs 49ers	10/03/2021 4:05PM
5	49ers vs Cardinals	10/10/2021 4:25PM
6	San Francisco 49ers Bye	N/A
7	Colts vs 49ers	10/24/2021 8:20PM
8	49ers vs Bears	10/31/2021 1:00PM
9	Cardinals vs 49ers	11/07/2021 4:25PM
10	Rams vs 49ers	11/15/2021 8:15PM
11	49ers vs Jaguars	11/21/2021 1:00PM
12	Vikings vs 49ers	11/28/2021 4:25PM
13	49ers vs Seahawks	12/05/2021 8:20PM
14	49ers vs Bengals	12/12/2021 1:00PM
15	Falcons vs 49ers	12/19/2021 4:05PM
16	49ers vs Titans	12/23/2021 8:20PM
17	Texans vs 49ers	01/02/2022 4:05PM

2021 Philadelphia Eagles Games & Results

Bye Week: 14

Week	Matchup	Date & Time
1	Eagles vs Falcons	PHI 32, ATL 6 09/12/2021
2	49ers vs Eagles	SF 17, PHI 11 09/19/2021
3	Eagles vs Cowboys	09/27/2021 8:15PM
4	Chiefs vs Eagles	10/03/2021 1:00PM
5	Eagles vs Panthers	10/10/2021 1:00PM
6	Buccaneers vs Eagles	10/14/2021 8:20PM
7	Eagles vs Raiders	10/24/2021 4:05PM
8	Eagles vs Lions	10/31/2021 1:00PM
9	Chargers vs Eagles	11/07/2021 4:05PM
10	Eagles vs Broncos	11/14/2021 4:25PM
11	Saints vs Eagles	11/21/2021 1:00PM
12	Eagles vs Giants	11/28/2021 1:00PM
13	Eagles vs Jets	12/05/2021 1:00PM
14	Philadelphia Eagles Bye	N/A
15	TBD vs Eagles	TBD 12/19/2021
16	Giants vs Eagles	12/26/2021 1:00PM
17	Eagles vs TBD	01/02/2022 1:00PM

Other 2021 Week 2 Matchups

Matchup	Date & Time
Giants vs TBD	WSH 30, NYG 29 09/16/2021
Bengals vs Bears	CHI 20, CIN 17 09/19/2021
Texans vs Browns	CLE 31, HOU 21 09/19/2021
Rams vs Colts	LAR 27, IND 24 09/19/2021
Bills vs Dolphins	BUF 35, MIA 0 09/19/2021
Patriots vs Jets	NE 25, NYJ 6 09/19/2021
49ers vs Eagles	SF 17, PHI 11 09/19/2021
Raiders vs Steelers	LV 26, PIT 17 09/19/2021
Saints vs Panthers	CAR 26, NO 7 09/19/2021
Broncos vs Jaguars	DEN 23, JAX 13 09/19/2021
Vikings vs Cardinals	ARI 34, MIN 33 09/19/2021
Falcons vs Buccaneers	TB 48, ATL 25 09/19/2021
Cowboys vs Chargers	DAL 20, LAC 17 09/19/2021
Titans vs Seahawks	TEN 33, SEA 30 (OT) 09/19/2021
Chiefs vs Ravens	BAL 36, KC 35 09/19/2021
Lions vs Packers	GB 35, DET 17 09/20/2021