The Bills will play the Rams on Thursday, September 8th, 2022. The matchup takes place at SoFi Stadium. Watch this exciting Week 1 matchup at 8:20 pm EDT. Check local listings for coverage on NBC.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Best Bills at Rams Odds
| Underdog Los Angeles Rams | Favorite Buffalo Bills |
|---|---|
| Over | Under |
|---|---|
| Underdog Los Angeles Rams | Favorite Buffalo Bills |
|---|---|
Matchup Odds FAQs
The Buffalo Bills are -2.5 -109 point spread favorites at BetRivers, while the Los Angeles Rams are +2.5 -112 point spread underdogs at BetRivers.
The best over line is 51.5 -113 points at BetRivers, which means you risk $113 to win $100 betting the over. The best under line is 51.5 -108 points at BetRivers, and that means you risk $108 to win $100 betting the under.
The Buffalo Bills are the -132 moneyline favorite at BetRivers and the Los Angeles Rams are the +117 moneyline underdog at BetRivers.
NFL Odds Example
|
Game |
 BetRiversBet |
|---|---|
Bills
Rams
9/08/22 8:20pm EDT | -2.5 -109+2.5 -112 |
Underdog Los Angeles Rams - Los Angeles Rams bettors risk $100 to win $89.29 at -112 odds.
A +2.5 Los Angeles Rams underdog bet wins if they lose by 2 or fewer, tie, or win outright. Your bet loses if they lose by 3 or more.
Favorite Buffalo Bills - Buffalo Bills bettors risk $100 to win $91.74 at -109 odds.
A -2.5 Buffalo Bills favorite bet wins if they win by 3 or more. Your bet loses if they win by 2 or fewer, tie, or lose outright.
Buffalo Bills at Los Angeles Rams Prop Bets
 BetMGMBet |
|
|---|---|
Bills
Rams
9/08/22 8:20pm EDT | Pending BetMGM |
Recent Meetings Since 2018
| Week | Game | Result | Margin |
|---|---|---|---|
| 2022 Week 1 | Bills vs Rams Thursday, September 8th, 2022 | BUF 31, LAR 10 SoFi Stadium | Bills by 21 |
| 2020 Week 3 | Rams vs Bills Sunday, September 27th, 2020 | BUF 35, LAR 32 Highmark Stadium | Bills by 3 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xz - Buffalo Bills | 13 | 3 | 0 | 0.813 | 455 | 286 | 7-1-0 | 6-2-0 | 4-2-0 | 0.667 | 9-2-0 | 0.818 | 7W | 5-0-0 |
| Los Angeles Rams | 5 | 12 | 0 | 0.294 | 307 | 384 | 4-5-0 | 1-7-0 | 1-5-0 | 0.167 | 3-9-0 | 0.250 | 2L | 2-3-0 |
Buffalo Bills & Los Angeles Rams Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Buffalo Bills Futures Odds|
Team | BetMGM |
BetRivers |
|---|---|---|
| Bills | +1400 Bet | +1400 Bet |
|
Team | BetMGM |
BetRivers |
|---|---|---|
| Rams | +3000 Bet | +2800 Bet |
Buffalo Bills & Los Angeles Rams Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Buffalo Bills vs Los Angeles Rams NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Thursday, September 8th, 2022 at 8:20 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Buffalo Bills vs Los Angeles Rams Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Buffalo Bills vs Los Angeles Rams Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 8, 2022 NFL Games
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