Buffalo Bills vs Los Angeles Rams Odds

The Bills will play the Rams on Thursday, September 8th, 2022. The matchup takes place at SoFi Stadium. Watch this exciting Week 1 matchup at 8:20 pm EDT. Check local listings for coverage on NBC.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.


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Table of Contents

Best Bills at Rams Odds


Best Point Spread Betting Odds
Underdog

Los Angeles Rams
Favorite

Buffalo Bills
The Buffalo Bills have a -2.5 -109 point spread at BetRivers VA. They are the point spread favorite in this matchup. The Los Angeles Rams have a +2.5 -112 point spread at BetRivers VA. The Los Angeles Rams are the point spread underdogs. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetRivers has the best over line of 51.5 points. Risk $113 to win $100. BetRivers has the best under line of 51.5 points. Risk $108 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

Los Angeles Rams
Favorite

Buffalo Bills
The Buffalo Bills are the -132 moneyline favorite. Risk $132 to win $100 on the Buffalo Bills at BetRivers. The Los Angeles Rams are the +117 underdog at BetRivers. Risk $100 to win $117 on the Los Angeles Rams. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Buffalo Bills vs Los Angeles Rams NFL game on Thursday, September 8th, 2022?

The Buffalo Bills are -2.5 -109 point spread favorites at BetRivers, while the Los Angeles Rams are +2.5 -112 point spread underdogs at BetRivers.

What is the over-under total line for the Buffalo Bills vs Los Angeles Rams NFL game on Thursday, September 8th, 2022?

The best over line is 51.5 -113 points at BetRivers, which means you risk $113 to win $100 betting the over. The best under line is 51.5 -108 points at BetRivers, and that means you risk $108 to win $100 betting the under.

What is the moneyline for the Buffalo Bills vs Los Angeles Rams NFL game on Thursday, September 8th, 2022?

The Buffalo Bills are the -132 moneyline favorite at BetRivers and the Los Angeles Rams are the +117 moneyline underdog at BetRivers.

NFL Odds Example

NFL Odds and Outcomes Explained

Game
BetRivers Sports Betting BetRivers
Bet
Bills
Rams
9/08/22 8:20pm EDT
-2.5 -109+2.5 -112
Bet $100 at BetRivers Virginia
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Underdog Los Angeles Rams - Los Angeles Rams bettors risk $100 to win $89.29 at -112 odds.

A +2.5 Los Angeles Rams underdog bet wins if they lose by 2 or fewer, tie, or win outright. Your bet loses if they lose by 3 or more.

Favorite Buffalo Bills - Buffalo Bills bettors risk $100 to win $91.74 at -109 odds.

A -2.5 Buffalo Bills favorite bet wins if they win by 3 or more. Your bet loses if they win by 2 or fewer, tie, or lose outright.

Buffalo Bills at Los Angeles Rams Prop Bets

NFL Prop Bets
+ Displays more odds
BetRivers Sports Betting BetRivers
Bet
Bills
Rams
First Team To Score
9/08/22 8:20pm EDT
-118-110Bet
Bills
Rams
Tie
First to 15 Points
9/08/22 8:20pm EDT
-137+105+2800Bet
Bills
Rams
Tie
First to 20 Points
9/08/22 8:20pm EDT
-117+116+950Bet

Recent Meetings Since 2018

Recent Meetings Since 2018
WeekGameResultMargin
2022
Week 1
Bills vs Rams
Thursday, September 8th, 2022
BUF 31, LAR 10
SoFi Stadium
Bills by 21
2020
Week 3
Rams vs Bills
Sunday, September 27th, 2020
BUF 35, LAR 32
Highmark Stadium
Bills by 3

Team Standings

2022-2023 NFL Regular Season Standings - Buffalo Bills, Los Angeles Rams
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
xz - Buffalo Bills13300.8134552867-1-06-2-04-2-00.6679-2-00.8187W5-0-0
Los Angeles Rams51200.2943073844-5-01-7-01-5-00.1673-9-00.2502L2-3-0

Buffalo Bills & Los Angeles Rams Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Buffalo Bills Futures Odds
2024-25 Buffalo Bills Super Bowl Odds

Team
BetRivers Sports Betting BetRivers BetMGM Sports Betting BetMGM
Bills
+1400
Bet
+1500
Bet
Los Angeles Rams Futures Odds
2024-25 Los Angeles Rams Super Bowl Odds

Team
BetRivers Sports Betting BetRivers BetMGM Sports Betting BetMGM
Rams
+2800
Bet
+3000
Bet

Buffalo Bills & Los Angeles Rams Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Buffalo Bills vs Los Angeles Rams NFL Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Thursday, September 8th, 2022 at 8:20 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's NFL page, look for the Buffalo Bills vs Los Angeles Rams Game.

    Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Buffalo Bills vs Los Angeles Rams Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other September 8, 2022 NFL Games

Matchup
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