Seattle Seahawks vs Arizona Cardinals Odds

The Seahawks will play the Cardinals on Thursday, September 25th, 2025. The matchup takes place at State Farm Stadium. Watch this exciting Week 4 matchup at 8:15 pm EDT. Check local listings for coverage on Prime Video.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.


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Table of Contents

Key Matchup Stats

The Seattle Seahawks and Arizona Cardinals will take the field at State Farm Stadium for a key Week 4 matchup on Thursday, September 25th, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.

  • SportsBetting3.com Power Rankings - Heading into Week 4 of the 2025-26 season, the Seattle Seahawks have a power ranking of 99.00. Our calculations have the Arizona Cardinals at a 95.33 power ranking.
  • Away Seattle Seahawks - Now in the middle of the season, the Seattle Seahawks have a 1-0-0 record as an away team, ranking them 2nd in the league for away team wins.
  • Home Arizona Cardinals - The Arizona Cardinals come to this Week 4 matchup with a 1-0-0 record as a home team. They rank 2nd in the league for home team wins so far this season.
  • Points Scored - The Seattle Seahawks currently rank 3rd (88) on the edge of Week 4, with the Arizona Cardinals ranked 16th (62) for points scored to date.
  • Points Against - The Seattle Seahawks stand 25th (47) in the middle weeks of the regular season for points against. As for the Arizona Cardinals, they currently rank 21st (51) for points against.
  • Team Records - Standings become more important now more than ever. Approaching Week 4, the Seattle Seahawks have a 2-1-0 record, with the Arizona Cardinals at 2-1-0 for the 2025-26 regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast ye, mateys! The Seattle Seahawks be facing the Arizona Cardinals on Thursday!

Both teams be standin' at 2-1-0, makin' this a crucial mid-season clash!

This battle be happenin' at State Farm Stadium in a city rich in culture.

The Seahawks be rankin' higher in the Power Rankings, but the Cardinals be no pushovers.

Bet this game at BetMGM or our preferred sports betting partner BetRivers, look at this game's prop bets, and compare odds from partner sports betting sites before settin' sail on your wager journey! Arrr!

Best Seahawks at Cardinals Odds


Best Point Spread Betting Odds
Underdog

Arizona Cardinals
Favorite

Seattle Seahawks
The Seattle Seahawks have a -1.5 -102 point spread at BetMGM OH. They are the point spread favorite in this matchup. The Arizona Cardinals have a +1.5 -102 point spread at BetMGM OH. The Arizona Cardinals are the point spread underdogs. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 43.5 points. Risk $110 to win $100. BetMGM has the best under line of 43.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

Arizona Cardinals
Favorite

Seattle Seahawks
The Seattle Seahawks are the -125 moneyline favorite. Risk $125 to win $100 on the Seattle Seahawks at BetMGM. The Arizona Cardinals are the +105 underdog at BetMGM. Risk $100 to win $105 on the Arizona Cardinals. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Seattle Seahawks vs Arizona Cardinals NFL game on Thursday, September 25th, 2025?

The Seattle Seahawks are -1.5 -102 point spread favorites at BetMGM, while the Arizona Cardinals are +1.5 -102 point spread underdogs at BetMGM.

What is the over-under total line for the Seattle Seahawks vs Arizona Cardinals NFL game on Thursday, September 25th, 2025?

The best over line is 43.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 43.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Seattle Seahawks vs Arizona Cardinals NFL game on Thursday, September 25th, 2025?

The Seattle Seahawks are the -125 moneyline favorite at BetMGM and the Arizona Cardinals are the +105 moneyline underdog at BetMGM.

NFL Odds Example

NFL Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Seahawks
Cardinals
9/25/25 8:15pm EDT
-1.5 -102+1.5 -102
Bet $100 at BetMGM Ohio
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Underdog Arizona Cardinals - Arizona Cardinals bettors risk $100 to win $98.04 at -102 odds.

A +1.5 Arizona Cardinals underdog bet wins if they lose by 1, tie, or win outright. Your bet loses if they lose by 2 or more.

Favorite Seattle Seahawks - Seattle Seahawks bettors risk $100 to win $98.04 at -102 odds.

A -1.5 Seattle Seahawks favorite bet wins if they win by 2 or more. Your bet loses if they win by 1, tie, or lose outright.

Seattle Seahawks at Arizona Cardinals Prop Bets

NFL Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Seahawks
Cardinals
First Team To Score
9/25/25 8:15pm EDT
-115-110Bet
Seahawks
Cardinals
No Touchdown
To Score 1st Touchdown
9/25/25 8:15pm EDT
-118-110+8000Bet
Seahawks
Cardinals
Game to Overtime
9/25/25 8:15pm EDT
Yes +700No -2000Bet
Seahawks
Cardinals
Safety to be Scored
9/25/25 8:15pm EDT
Yes +1000No -3000Bet
BetMGM Sports Betting BetMGM
Kyler Murray
Interceptions Thrown
SEA at ARI
9/25/25 8:15pm EDT
0.5 o -1200.5 u -110Bet
Sam Darnold
Interceptions Thrown
SEA at ARI
9/25/25 8:15pm EDT
0.5 o -1150.5 u -115Bet
Kyler Murray
Longest Passing Completion
SEA at ARI
9/25/25 8:15pm EDT
33.5 o -12033.5 u -110Bet
Sam Darnold
Longest Passing Completion
SEA at ARI
9/25/25 8:15pm EDT
35.5 o -11035.5 u -118Bet
BetMGM Sports Betting BetMGM
Chad Ryland
Total Kicking Points
SEA at ARI
9/25/25 8:15pm EDT
6.5 o -1606.5 u +120Bet
Jason Myers
Total Kicking Points
SEA at ARI
9/25/25 8:15pm EDT
7.5 o +1057.5 u -140Bet
Kyler Murray
Total Pass Completions
SEA at ARI
9/25/25 8:15pm EDT
21.5 o -15021.5 u +110Bet
Sam Darnold
Total Pass Completions
SEA at ARI
9/25/25 8:15pm EDT
20.5 o -13520.5 u +100Bet
BetMGM Sports Betting BetMGM
Kyler Murray
Total Passing Yards
SEA at ARI
9/25/25 8:15pm EDT
223.5 o -115223.5 u -115Bet
Sam Darnold
Total Passing Yards
SEA at ARI
9/25/25 8:15pm EDT
224.5 o -115224.5 u -115Bet
Kyler Murray
Total Touchdown Passes
SEA at ARI
9/25/25 8:15pm EDT
1.5 o +1051.5 u -140Bet
Sam Darnold
Total Touchdown Passes
SEA at ARI
9/25/25 8:15pm EDT
1.5 o +1301.5 u -165Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
WeekGameResultMargin
2025
Week 4
Seahawks vs Cardinals
Thursday, September 25th, 2025
SEA 23, ARI 20
State Farm Stadium
Seahawks by 3
2024
Week 14
Seahawks vs Cardinals
Sunday, December 8th, 2024
SEA 30, ARI 18
State Farm Stadium
Seahawks by 12
2024
Week 12
Cardinals vs Seahawks
Sunday, November 24th, 2024
SEA 16, ARI 6
Lumen Field
Seahawks by 10
2023
Week 18
Seahawks vs Cardinals
Sunday, January 7th, 2024
SEA 21, ARI 20
State Farm Stadium
Seahawks by 1
2023
Week 7
Cardinals vs Seahawks
Sunday, October 22nd, 2023
SEA 20, ARI 10
Lumen Field
Seahawks by 10
2022
Week 9
Seahawks vs Cardinals
Sunday, November 6th, 2022
SEA 31, ARI 21
State Farm Stadium
Seahawks by 10
2022
Week 6
Cardinals vs Seahawks
Sunday, October 16th, 2022
SEA 19, ARI 9
Lumen Field
Seahawks by 10
2021
Week 18
Seahawks vs Cardinals
Sunday, January 9th, 2022
SEA 38, ARI 30
State Farm Stadium
Seahawks by 8
2021
Week 11
Cardinals vs Seahawks
Sunday, November 21st, 2021
ARI 23, SEA 13
Lumen Field
Cardinals by 10

Team Standings

2025-2026 NFL Regular Season Standings - Seattle Seahawks, Arizona Cardinals
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
Seattle Seahawks5200.7141931362-2-03-0-01-1-00.5002-2-00.5002W4-1-0
Arizona Cardinals2500.2861531541-3-01-2-00-2-00.0002-3-00.4005L0-5-0

Seattle Seahawks & Arizona Cardinals Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Seattle Seahawks Futures Odds
2025-26 Seattle Seahawks Super Bowl Odds

Team
BetMGM Sports Betting BetMGM
Seahawks
+2500
Bet
Arizona Cardinals Futures Odds
2025-26 Arizona Cardinals Super Bowl Odds

Team
BetMGM Sports Betting BetMGM
Cardinals
+50000
Bet

Seattle Seahawks & Arizona Cardinals Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Seattle Seahawks vs Arizona Cardinals NFL Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Thursday, September 25th, 2025 at 8:15 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's NFL page, look for the Seattle Seahawks vs Arizona Cardinals Game.

    Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Seattle Seahawks vs Arizona Cardinals Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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