The 49ers will play the Broncos on Sunday, September 25th, 2022. The matchup takes place at Empower Field at Mile High. Watch this exciting Week 3 matchup at 7:20 pm CDT. Check local listings for coverage on NBC.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Best 49ers at Broncos Odds
| Underdog Denver Broncos | Favorite San Francisco 49ers |
|---|---|
| Over | Under |
|---|---|
| Underdog Denver Broncos | Favorite San Francisco 49ers |
|---|---|
Matchup Odds FAQs
The San Francisco 49ers are -1.5 -109 point spread favorites at BetRivers, while the Denver Broncos are +1.5 -112 point spread underdogs at BetRivers.
The best over line is 44.5 -109 points at BetRivers, which means you risk $109 to win $100 betting the over. The best under line is 44.5 -112 points at BetRivers, and that means you risk $112 to win $100 betting the under.
The San Francisco 49ers are the -125 moneyline favorite at BetRivers and the Denver Broncos are the +110 moneyline underdog at BetRivers.
NFL Odds Example
|
Game |
 BetRiversBet |
|---|---|
49ers
Broncos
9/25/22 7:20pm CDT | -1.5 -109+1.5 -112 |
Underdog Denver Broncos - Denver Broncos bettors risk $100 to win $89.29 at -112 odds.
A +1.5 Denver Broncos underdog bet wins if they lose by 1, tie, or win outright. Your bet loses if they lose by 2 or more.
Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $91.74 at -109 odds.
A -1.5 San Francisco 49ers favorite bet wins if they win by 2 or more. Your bet loses if they win by 1, tie, or lose outright.
San Francisco 49ers at Denver Broncos Prop Bets
 BetMGMBet |
|
|---|---|
49ers
Broncos
9/25/22 7:20pm CDT | Pending BetMGM |
Recent Meetings Since 2018
| Week | Game | Result | Margin |
|---|---|---|---|
| 2023 Preseason Week 2 | Broncos vs 49ers Saturday, August 19th, 2023 | SF 21, DEN 20 Levi's Stadium | 49ers by 1 |
| 2022 Week 3 | 49ers vs Broncos Sunday, September 25th, 2022 | DEN 11, SF 10 Empower Field at Mile High | Broncos by 1 |
| 2019 Preseason Week 2 | 49ers vs Broncos Monday, August 19th, 2019 | SF 24, DEN 15 Empower Field at Mile High | 49ers by 9 |
| 2018 Week 14 | Broncos vs 49ers Sunday, December 9th, 2018 | SF 20, DEN 14 Levi's Stadium | 49ers by 6 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xz - San Francisco 49ers | 13 | 4 | 0 | 0.765 | 450 | 277 | 8-1-0 | 5-3-0 | 6-0-0 | 1.000 | 10-2-0 | 0.833 | 10W | 5-0-0 |
| Denver Broncos | 5 | 12 | 0 | 0.294 | 287 | 359 | 4-4-0 | 1-8-0 | 1-5-0 | 0.167 | 3-9-0 | 0.250 | 1W | 2-3-0 |
San Francisco 49ers & Denver Broncos Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
San Francisco 49ers Futures Odds|
Team | BetMGM |
|---|---|
| 49ers | +1800 Bet |
|
Team | BetMGM |
|---|---|
| Broncos | +4000 Bet |
San Francisco 49ers & Denver Broncos Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco 49ers vs Denver Broncos NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 25th, 2022 at 7:20 pm CDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Denver Broncos Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Denver Broncos Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 25, 2022 NFL Games
- New Orleans Saints vs Carolina Panthers
- Houston Texans vs Chicago Bears
- Philadelphia Eagles vs Washington Commanders
- Las Vegas Raiders vs Tennessee Titans
- Cincinnati Bengals vs New York Jets
- Baltimore Ravens vs New England Patriots
- Detroit Lions vs Minnesota Vikings
- Buffalo Bills vs Miami Dolphins
- Kansas City Chiefs vs Indianapolis Colts
- Jacksonville Jaguars vs Los Angeles Chargers
- Los Angeles Rams vs Arizona Cardinals
- Atlanta Falcons vs Seattle Seahawks
- Green Bay Packers vs Tampa Bay Buccaneers