The 49ers will play the Broncos on Sunday, September 25th, 2022. The matchup takes place at Empower Field at Mile High. Watch this exciting Week 3 matchup at 8:20 pm EDT. Check local listings for coverage on NBC.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

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Best 49ers at Broncos Odds

**Best Point Spread Betting Odds**
TBD	TBD

Point Spread odds are updating, please check back soon.

**Best Total Betting Odds**
Over	Under

Total odds are updating, please check back soon.

**Best Moneyline Betting Odds**
TBD	TBD

Moneyline odds are updating, please check back soon.

NFL Odds Example

NFL Odds and Outcomes Explained
Game	Book

San Francisco 49ers at Denver Broncos Prop Bets

NFL Prop Bets
+ Displays more odds
	BetMGM Bet
49ers Broncos 9/25/22 8:20pm EDT	Pending BetMGM

Recent Meetings Since 2018

Recent Meetings Since 2018
Week	Game	Result	Margin
2023 Preseason Week 2	Broncos vs 49ers Saturday, August 19th, 2023	SF 21, DEN 20 Levi's Stadium	49ers by 1
2022 Week 3	49ers vs Broncos Sunday, September 25th, 2022	DEN 11, SF 10 Empower Field at Mile High	Broncos by 1
2019 Preseason Week 2	49ers vs Broncos Monday, August 19th, 2019	SF 24, DEN 15 Empower Field at Mile High	49ers by 9
2018 Week 14	Broncos vs 49ers Sunday, December 9th, 2018	SF 20, DEN 14 Levi's Stadium	49ers by 6

Team Standings

2022-2023 NFL Regular Season Standings - San Francisco 49ers, Denver Broncos
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xz - San Francisco 49ers	13	4	0	0.765	450	277	8-1-0	5-3-0	6-0-0	1.000	10-2-0	0.833	10W	5-0-0
Denver Broncos	5	12	0	0.294	287	359	4-4-0	1-8-0	1-5-0	0.167	3-9-0	0.250	1W	2-3-0

San Francisco 49ers & Denver Broncos Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds

2025-26 San Francisco 49ers Super Bowl Odds
Team	BetMGM
49ers	+2000 Bet

Denver Broncos Futures Odds

2025-26 Denver Broncos Super Bowl Odds
Team	BetMGM
Broncos	+4000 Bet

San Francisco 49ers & Denver Broncos Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco 49ers vs Denver Broncos NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 25th, 2022 at 8:20 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Denver Broncos Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Denver Broncos Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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San Francisco 49ers vs Denver Broncos Odds

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