San Francisco 49ers vs Denver Broncos Odds

The 49ers will play the Broncos on Sunday, September 25th, 2022. The matchup takes place at Empower Field at Mile High. Watch this exciting Week 3 matchup at 8:20 pm EDT. Check local listings for coverage on NBC.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.


Bonus
BetRivers Sportsbook#1 BetRivers
REVIEW
New Customers - 2nd Chance Bet up to $500 - Code: SPORTS
Bet Now
21+ Playable in VA only
Gambling Problem? Call 1-888-532-3500
BetMGM Sportsbook#2 BetMGM
REVIEW
New Customers - Up to $1500 Paid Back in Bonus Bets
Bonus Bets Expire in 7 Days
One new customer offer/Add'l Terms

Bet Now
21+ Playable in VA only
Gambling Problem? Call 1-888-532-3500

Table of Contents

Best 49ers at Broncos Odds


Best Point Spread Betting Odds
Underdog

Denver Broncos
Favorite

San Francisco 49ers
The San Francisco 49ers have a -1.5 -109 point spread at BetRivers VA. They are the point spread favorite in this matchup. The Denver Broncos have a +1.5 -112 point spread at BetRivers VA. The Denver Broncos are the point spread underdogs. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetRivers has the best over line of 44.5 points. Risk $109 to win $100. BetRivers has the best under line of 44.5 points. Risk $112 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

Denver Broncos
Favorite

San Francisco 49ers
The San Francisco 49ers are the -125 moneyline favorite. Risk $125 to win $100 on the San Francisco 49ers at BetRivers. The Denver Broncos are the +110 underdog at BetRivers. Risk $100 to win $110 on the Denver Broncos. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the San Francisco 49ers vs Denver Broncos NFL game on Sunday, September 25th, 2022?

The San Francisco 49ers are -1.5 -109 point spread favorites at BetRivers, while the Denver Broncos are +1.5 -112 point spread underdogs at BetRivers.

What is the over-under total line for the San Francisco 49ers vs Denver Broncos NFL game on Sunday, September 25th, 2022?

The best over line is 44.5 -109 points at BetRivers, which means you risk $109 to win $100 betting the over. The best under line is 44.5 -112 points at BetRivers, and that means you risk $112 to win $100 betting the under.

What is the moneyline for the San Francisco 49ers vs Denver Broncos NFL game on Sunday, September 25th, 2022?

The San Francisco 49ers are the -125 moneyline favorite at BetRivers and the Denver Broncos are the +110 moneyline underdog at BetRivers.

NFL Odds Example

NFL Odds and Outcomes Explained

Game
BetRivers Sports Betting BetRivers
Bet
49ers
Broncos
9/25/22 8:20pm EDT
-1.5 -109+1.5 -112
Bet $100 at BetRivers Virginia
21+ Playable in VA only
Gambling Problem? Call 1-888-532-3500

Underdog Denver Broncos - Denver Broncos bettors risk $100 to win $89.29 at -112 odds.

A +1.5 Denver Broncos underdog bet wins if they lose by 1, tie, or win outright. Your bet loses if they lose by 2 or more.

Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $91.74 at -109 odds.

A -1.5 San Francisco 49ers favorite bet wins if they win by 2 or more. Your bet loses if they win by 1, tie, or lose outright.

San Francisco 49ers at Denver Broncos Prop Bets

NFL Prop Bets
+ Displays more odds
BetRivers Sports Betting BetRivers
Bet
49ers
Broncos
First Team To Score
9/25/22 8:20pm EDT
-120-109Bet
49ers
Broncos
Tie
First to 15 Points
9/25/22 8:20pm EDT
-122+110+1500Bet
49ers
Broncos
Tie
First to 20 Points
9/25/22 8:20pm EDT
+106+125+525Bet

Recent Meetings Since 2018

Recent Meetings Since 2018
WeekGameResultMargin
2023
Preseason Week 2
Broncos vs 49ers
Saturday, August 19th, 2023
SF 21, DEN 20
Levi's Stadium
49ers by 1
2022
Week 3
49ers vs Broncos
Sunday, September 25th, 2022
DEN 11, SF 10
Empower Field at Mile High
Broncos by 1
2019
Preseason Week 2
49ers vs Broncos
Monday, August 19th, 2019
SF 24, DEN 15
Empower Field at Mile High
49ers by 9
2018
Week 14
Broncos vs 49ers
Sunday, December 9th, 2018
SF 20, DEN 14
Levi's Stadium
49ers by 6

Team Standings

2022-2023 NFL Regular Season Standings - San Francisco 49ers, Denver Broncos
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
xz - San Francisco 49ers13400.7654502778-1-05-3-06-0-01.00010-2-00.83310W5-0-0
Denver Broncos51200.2942873594-4-01-8-01-5-00.1673-9-00.2501W2-3-0

San Francisco 49ers & Denver Broncos Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds
2024-25 San Francisco 49ers Super Bowl Odds

Team
BetRivers Sports Betting BetRivers BetMGM Sports Betting BetMGM
49ers
+600
Bet
+650
Bet
Denver Broncos Futures Odds
2024-25 Denver Broncos Super Bowl Odds

Team
BetRivers Sports Betting BetRivers BetMGM Sports Betting BetMGM
Broncos
+12500
Bet
+12500
Bet

San Francisco 49ers & Denver Broncos Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco 49ers vs Denver Broncos NFL Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 25th, 2022 at 8:20 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Denver Broncos Game.

    Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Denver Broncos Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other September 25, 2022 NFL Games

Matchup
New Orleans Saints vs
Carolina Panthers
Houston Texans vs
Chicago Bears
Philadelphia Eagles vs
Washington Commanders
Las Vegas Raiders vs
Tennessee Titans
Cincinnati Bengals vs
New York Jets
Baltimore Ravens vs
New England Patriots
Detroit Lions vs
Minnesota Vikings
Buffalo Bills vs
Miami Dolphins
Kansas City Chiefs vs
Indianapolis Colts
Jacksonville Jaguars vs
Los Angeles Chargers
Los Angeles Rams vs
Arizona Cardinals
Atlanta Falcons vs
Seattle Seahawks
Green Bay Packers vs
Tampa Bay Buccaneers
Odds Preview 727