San Francisco 49ers vs Denver Broncos Odds

The 49ers will play the Broncos on Sunday, September 25th, 2022. The matchup takes place at Empower Field at Mile High. Watch this exciting Week 3 matchup at 8:20 pm EDT. Check local listings for coverage on NBC.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props. Read the following to understand point spread betting.

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Point Spread
Underdog

Denver Broncos
Favorite

San Francisco 49ers
SportsBetting3.com has analyzed the latest lines. Review our "Point Spread" table above to smash the books. BetRivers VA has the best favorite San Francisco 49ers point spread at -1.5 points. BetRivers has the best underdog Denver Broncos point spread at +1.5 points. Review our point spread betting tutorial and video for more information.

Total
OverUnder
The over under line estimates the combined total of each team's final score. BetRivers has the best over line of 44.5 points laying $109 to win $100. BetRivers has the best under line of 44.5 points.

Moneyline
Underdog

Denver Broncos
Favorite

San Francisco 49ers
Here are money lines for the outright winner. Favorite San Francisco 49ers has a minus value. Lay $125 to win $100 at BetRivers. Underdog Denver Broncos has a positive value. Risk $100 at BetRivers to win $110.

NFL Odds Example

NFL Odds and Outcomes Explained

Game
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49ers
Broncos
9/25/22 8:20pm EDT
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Underdog Denver Broncos - Denver Broncos bettors risk $100 to win $89.29 at -112 odds.

A +1.5 Denver Broncos underdog bet wins if they lose by 1, tie, or win outright. Your bet loses if they lose by 2 or more.

Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $91.74 at -109 odds.

A -1.5 San Francisco 49ers favorite bet wins if they win by 2 or more. Your bet loses if they win by 1, tie, or lose outright.

San Francisco 49ers at Denver Broncos Prop Bets

NFL Prop Bets
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Bet
49ers
Broncos
First Team To Score
9/25/22 8:20pm EDT
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49ers
Broncos
Tie
First to 15 Points
9/25/22 8:20pm EDT
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49ers
Broncos
Tie
First to 20 Points
9/25/22 8:20pm EDT
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Recent Meetings Since 2018

Recent Meetings Since 2018
WeekGameResultMargin
2022
Week 3
49ers vs Broncos
Sunday, September 25th, 2022
DEN 11, SF 10
Empower Field at Mile High
Broncos by 1
2019
Pre Preseason Week 2
49ers vs Broncos
Monday, August 19th, 2019
SF 24, DEN 15
Empower Field at Mile High
49ers by 9
2018
Week 14
Broncos vs 49ers
Sunday, December 9th, 2018
SF 20, DEN 14
Levi's Stadium
49ers by 6

Team Standings

2022-2023 NFL Regular Season Standings - San Francisco 49ers, Denver Broncos
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
xz - San Francisco 49ers13400.7654502778-1-05-3-06-0-01.00010-2-00.83310W5-0-0
Denver Broncos51200.2942873594-4-01-8-01-5-00.1673-9-00.2501W2-3-0

Team Stats

San Francisco 49ers Team Stats
Stat San Francisco 49ers Opponents
Total 1st Downs 347 291
Total Offensive Yards 6216 5110
Total Rushing Yards 2360 1321
Total Passing Yards 4049 3789
Sacks 31 44
Field Goals 27 / 32 16 / 21
Touchdowns 52 32
Turnover Ratio 13

Denver Broncos Team Stats
Stat Denver Broncos Opponents
Total 1st Downs 300 324
Total Offensive Yards 5527 5440
Total Rushing Yards 1935 1866
Total Passing Yards 4007 3574
Sacks 63 36
Field Goals 28 / 36 39 / 41
Touchdowns 29 35
Turnover Ratio -1

Team Season Win Totals

The following are each team's season win totals. Learn more about season win totals.

San Francisco 49ers Season Win Total
2023 NFL San Francisco 49ers Season Win Total
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49ers
2023 Season Win Total
Denver Broncos Season Win Total
2023 NFL Denver Broncos Season Win Total
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Broncos
2023 Season Win Total

Team Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds
2024 San Francisco 49ers Super Bowl Winner Odds

Team
BetRivers BetRivers BetMGM BetMGM
49ers
Denver Broncos Futures Odds
2024 Denver Broncos Super Bowl Winner Odds

Team
BetRivers BetRivers BetMGM BetMGM
Broncos

2022-23 San Francisco 49ers Games & Results

2022-23 San Francisco 49ers Games & Results
WeekMatchupDate & Time
Preseason 1Packers vs
49ers
SF 28, GB 21
Friday, August 12th, 2022
Preseason 249ers vs
Vikings
SF 17, MIN 7
Saturday, August 20th, 2022
Preseason 349ers vs
Texans
HOU 17, SF 0
Thursday, August 25th, 2022
Week 149ers vs
Bears
CHI 19, SF 10
Sunday, September 11th, 2022
Week 2Seahawks vs
49ers
SF 27, SEA 7
Sunday, September 18th, 2022
Week 349ers vs
Broncos
DEN 11, SF 10
Sunday, September 25th, 2022
Week 4Rams vs
49ers
SF 24, LAR 9
Monday, October 3rd, 2022
Week 549ers vs
Panthers
SF 37, CAR 15
Sunday, October 9th, 2022
Week 649ers vs
Falcons
ATL 28, SF 14
Sunday, October 16th, 2022
Week 7Chiefs vs
49ers
KC 44, SF 23
Sunday, October 23rd, 2022
Week 849ers vs
Rams
SF 31, LAR 14
Sunday, October 30th, 2022
Week 949ers
Bye Week
Week 10Chargers vs
49ers
SF 22, LAC 16
Sunday, November 13th, 2022
Week 1149ers vs
Cardinals
SF 38, ARI 10
Monday, November 21st, 2022
Week 12Saints vs
49ers
SF 13, NO 0
Sunday, November 27th, 2022
Week 13Dolphins vs
49ers
SF 33, MIA 17
Sunday, December 4th, 2022
Week 14Buccaneers vs
49ers
SF 35, TB 7
Sunday, December 11th, 2022
Week 1549ers vs
Seahawks
SF 21, SEA 13
Thursday, December 15th, 2022
Week 16Commanders vs
49ers
SF 37, WSH 20
Saturday, December 24th, 2022
Week 1749ers vs
Raiders
SF 37, LV 34 (OT)
Sunday, January 1st, 2023
Week 18Cardinals vs
49ers
SF 38, ARI 13
Sunday, January 8th, 2023
Wild CardSeahawks vs
49ers
NFC Wild Card Playoffs
SF 41, SEA 23
Saturday, January 14th, 2023
Divisional RoundCowboys vs
49ers
NFC Divisional Playoffs
SF 19, DAL 12
Sunday, January 22nd, 2023
Conference Championship49ers vs
Eagles
NFC Championship
PHI 31, SF 7
Sunday, January 29th, 2023

2022-23 Denver Broncos Games & Results

2022-23 Denver Broncos Games & Results
WeekMatchupDate & Time
Preseason 1Cowboys vs
Broncos
DEN 17, DAL 7
Saturday, August 13th, 2022
Preseason 2Broncos vs
Bills
BUF 42, DEN 15
Saturday, August 20th, 2022
Preseason 3Vikings vs
Broncos
DEN 23, MIN 13
Saturday, August 27th, 2022
Week 1Broncos vs
Seahawks
SEA 17, DEN 16
Monday, September 12th, 2022
Week 2Texans vs
Broncos
DEN 16, HOU 9
Sunday, September 18th, 2022
Week 349ers vs
Broncos
DEN 11, SF 10
Sunday, September 25th, 2022
Week 4Broncos vs
Raiders
LV 32, DEN 23
Sunday, October 2nd, 2022
Week 5Colts vs
Broncos
IND 12, DEN 9 (OT)
Thursday, October 6th, 2022
Week 6Broncos vs
Chargers
LAC 19, DEN 16 (OT)
Monday, October 17th, 2022
Week 7Jets vs
Broncos
NYJ 16, DEN 9
Sunday, October 23rd, 2022
Week 8Broncos vs
Jaguars
DEN 21, JAX 17
Sunday, October 30th, 2022
Week 9Broncos
Bye Week
Week 10Broncos vs
Titans
TEN 17, DEN 10
Sunday, November 13th, 2022
Week 11Raiders vs
Broncos
LV 22, DEN 16 (OT)
Sunday, November 20th, 2022
Week 12Broncos vs
Panthers
CAR 23, DEN 10
Sunday, November 27th, 2022
Week 13Broncos vs
Ravens
BAL 10, DEN 9
Sunday, December 4th, 2022
Week 14Chiefs vs
Broncos
KC 34, DEN 28
Sunday, December 11th, 2022
Week 15Cardinals vs
Broncos
DEN 24, ARI 15
Sunday, December 18th, 2022
Week 16Broncos vs
Rams
LAR 51, DEN 14
Sunday, December 25th, 2022
Week 17Broncos vs
Chiefs
KC 27, DEN 24
Sunday, January 1st, 2023
Week 18Chargers vs
Broncos
DEN 31, LAC 28
Sunday, January 8th, 2023

Other September 25, 2022 NFL Games

Matchup
New Orleans Saints vs
Carolina Panthers
Houston Texans vs
Chicago Bears
Philadelphia Eagles vs
Washington Commanders
Las Vegas Raiders vs
Tennessee Titans
Cincinnati Bengals vs
New York Jets
Baltimore Ravens vs
New England Patriots
Detroit Lions vs
Minnesota Vikings
Buffalo Bills vs
Miami Dolphins
Kansas City Chiefs vs
Indianapolis Colts
Jacksonville Jaguars vs
Los Angeles Chargers
Los Angeles Rams vs
Arizona Cardinals
Atlanta Falcons vs
Seattle Seahawks
Green Bay Packers vs
Tampa Bay Buccaneers
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