San Francisco 49ers vs Detroit Lions Odds

The 49ers will play the Lions on Sunday, September 12th, 2021. The matchup takes place at Ford Field. Watch this exciting Week 1 matchup at 1:00 pm EDT. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props. Read the following to understand point spread betting.

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AZ CT DC IA IL IN KS LA MI MS NY OH PA TN VA WY
Point Spread

Underdog	Favorite

Point Spread odds are updating, please check back soon.

Total

Over	Under

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Moneyline

Underdog	Favorite

Moneyline odds are updating, please check back soon.

NFL Odds Example

San Francisco 49ers vs Detroit Lions 9/12/21 1:00pm EDT

NFL Odds and Outcomes Explained

AZ CT DC IA IL IN KS LA MI MS NY OH PA TN VA WY Point Spread Total Moneyline Game	Bet
8:25pm EDT	TBD VA

$100 $5 $10 $20 $50 $500 $1000

San Francisco 49ers at Detroit Lions Prop Bets

NFL Prop Bets
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AZ CT DC IA IL IN KS LA MI MS NY OH PA TN VA WY	BetRivers Bet
49ers Lions 9/12/21 1:00pm EDT	Pending BetRivers

Recent Meetings Since 2017

Week	Game	Result	Margin
2021 Week 1	49ers vs Lions Sunday, September 12th, 2021	SF 41, DET 33 Ford Field	49ers by 8
2018 Week 2	Lions vs 49ers Sunday, September 16th, 2018	SF 30, DET 27 Levi's Stadium	49ers by 3

Team Standings

2022-2023 2021-2022 2020-2021 2019-2020 2018-2019 2017-2018 2016-2017 2015-2016 2014-2015 2013-2014 2012-2013 2011-2012 2010-2011 2009-2010 2008-2009 2007-2008 2006-2007 2005-2006 2004-2005 2003-2004 2002-2003 2001-2002 2000-2001 1999-2000 1998-1999 1997-1998 1996-1997 1995-1996 1994-1995 1993-1994 1992-1993 1991-1992 1990-1991 1989-1990 1988-1989 1987-1988 1986-1987 1985-1986 1984-1985 1983-1984 1982-1983 1981-1982 1980-1981 1979-1980 1978-1979 1977-1978 1976-1977 1975-1976 1974-1975 1973-1974 1972-1973 1971-1972 1970-1971 Regular Preseason

2021-2022 NFL Regular Season Standings - San Francisco 49ers, Detroit Lions

Team	W	L	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xy - San Francisco 49ers	10	7	0.588	427	365	4-4-0	6-3-0	2-4-0	0.333	7-5-0	0.583	2W	4-1-0
Detroit Lions	3	13	0.206	325	467	3-5-0	0-8-1	2-4-0	0.333	3-9-0	0.250	1W	2-3-0

Team Stats

San Francisco 49ers Team Stats

Stat	San Francisco 49ers	Opponents
Total 1st Downs	361	318
Total Offensive Yards	6337	5270
Total Rushing Yards	2161	1760
Total Passing Yards	4437	3510
Sacks	33	48
Field Goals	27 / 32	21 / 27
Touchdowns	50	43
Turnover Ratio	-4

Detroit Lions Team Stats

Stat	Detroit Lions	Opponents
Total 1st Downs	329	372
Total Offensive Yards	5484	6456
Total Rushing Yards	1886	2296
Total Passing Yards	3884	4160
Sacks	36	30
Field Goals	26 / 30	36 / 41
Touchdowns	35	52
Turnover Ratio	-4

Team Season Win Totals

The following are each team's season win totals. Learn more about season win totals.

San Francisco 49ers Season Win Total

2022 NFL San Francisco 49ers Season Win Total
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AZ CT DC IA IL IN KS LA MI MS NY OH PA TN VA WY	BetRivers Bet
49ers 2022 Season Win Total	9.5 o -177 9.5 u +144

Detroit Lions Season Win Total

2022 NFL Detroit Lions Season Win Total
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AZ CT DC IA IL IN KS LA MI MS NY OH PA TN VA WY	BetRivers Bet
Lions 2022 Season Win Total	5.5 o -143 5.5 u +118

Team Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds

2024 San Francisco 49ers Super Bowl Winner Odds
Super Bowl Winner NFC Conference Winner NFC West Winner

AZ CT DC IA IL IN KS LA MI MS NY OH PA TN VA WY Team	BetRivers	BetMGM
49ers	+800 Bet	+900 Bet

Detroit Lions Futures Odds

2024 Detroit Lions Super Bowl Winner Odds
Super Bowl Winner NFC Conference Winner NFC North Winner

AZ CT DC IA IL IN KS LA MI MS NY OH PA TN VA WY Team	BetRivers	BetMGM
Lions	+2200 Bet	+2000 Bet

2021 San Francisco 49ers Games & Results

Week	Matchup	Date & Time
Preseason 1	Chiefs vs 49ers	KC 19, SF 16 Saturday, August 14th, 2021
Preseason 2	49ers vs Chargers	SF 15, LAC 10 Sunday, August 22nd, 2021
Preseason 3	Raiders vs 49ers	SF 34, LV 10 Sunday, August 29th, 2021
Week 1	49ers vs Lions	SF 41, DET 33 Sunday, September 12th, 2021
Week 2	49ers vs Eagles	SF 17, PHI 11 Sunday, September 19th, 2021
Week 3	Packers vs 49ers	GB 30, SF 28 Sunday, September 26th, 2021
Week 4	Seahawks vs 49ers	SEA 28, SF 21 Sunday, October 3rd, 2021
Week 5	49ers vs Cardinals	ARI 17, SF 10 Sunday, October 10th, 2021
Week 6	49ers Bye Week
Week 7	Colts vs 49ers	IND 30, SF 18 Sunday, October 24th, 2021
Week 8	49ers vs Bears	SF 33, CHI 22 Sunday, October 31st, 2021
Week 9	Cardinals vs 49ers	ARI 31, SF 17 Sunday, November 7th, 2021
Week 10	Rams vs 49ers	SF 31, LAR 10 Monday, November 15th, 2021
Week 11	49ers vs Jaguars	SF 30, JAX 10 Sunday, November 21st, 2021
Week 12	Vikings vs 49ers	SF 34, MIN 26 Sunday, November 28th, 2021
Week 13	49ers vs Seahawks	SEA 30, SF 23 Sunday, December 5th, 2021
Week 14	49ers vs Bengals	SF 26, CIN 23 (OT) Sunday, December 12th, 2021
Week 15	Falcons vs 49ers	SF 31, ATL 13 Sunday, December 19th, 2021
Week 16	49ers vs Titans	TEN 20, SF 17 Thursday, December 23rd, 2021
Week 17	Texans vs 49ers	SF 23, HOU 7 Sunday, January 2nd, 2022
Week 18	49ers vs Rams	SF 27, LAR 24 (OT) Sunday, January 9th, 2022
Wild Card	49ers vs Cowboys NFC Wild Card Playoffs	SF 23, DAL 17 Sunday, January 16th, 2022
Divisional Round	49ers vs Packers NFC Divisional Playoffs	SF 13, GB 10 Saturday, January 22nd, 2022
Conference Championship	49ers vs Rams NFC Championship	LAR 20, SF 17 Sunday, January 30th, 2022

2021 Detroit Lions Games & Results

Week	Matchup	Date & Time
Preseason 1	Bills vs Lions	BUF 16, DET 15 Friday, August 13th, 2021
Preseason 2	Lions vs Steelers	PIT 26, DET 20 Saturday, August 21st, 2021
Preseason 3	Colts vs Lions	IND 27, DET 17 Friday, August 27th, 2021
Week 1	49ers vs Lions	SF 41, DET 33 Sunday, September 12th, 2021
Week 2	Lions vs Packers	GB 35, DET 17 Monday, September 20th, 2021
Week 3	Ravens vs Lions	BAL 19, DET 17 Sunday, September 26th, 2021
Week 4	Lions vs Bears	CHI 24, DET 14 Sunday, October 3rd, 2021
Week 5	Lions vs Vikings	MIN 19, DET 17 Sunday, October 10th, 2021
Week 6	Bengals vs Lions	CIN 34, DET 11 Sunday, October 17th, 2021
Week 7	Lions vs Rams	LAR 28, DET 19 Sunday, October 24th, 2021
Week 8	Eagles vs Lions	PHI 44, DET 6 Sunday, October 31st, 2021
Week 9	Lions Bye Week
Week 10	Lions vs Steelers	DET 16, PIT 16 (OT) Sunday, November 14th, 2021
Week 11	Lions vs Browns	CLE 13, DET 10 Sunday, November 21st, 2021
Week 12	Bears vs Lions	CHI 16, DET 14 Thursday, November 25th, 2021
Week 13	Vikings vs Lions	DET 29, MIN 27 Sunday, December 5th, 2021
Week 14	Lions vs Broncos	DEN 38, DET 10 Sunday, December 12th, 2021
Week 15	Cardinals vs Lions	DET 30, ARI 12 Sunday, December 19th, 2021
Week 16	Lions vs Falcons	ATL 20, DET 16 Sunday, December 26th, 2021
Week 17	Lions vs Seahawks	SEA 51, DET 29 Sunday, January 2nd, 2022
Week 18	Packers vs Lions	DET 37, GB 30 Sunday, January 9th, 2022

Other September 12, 2021 NFL Games

Matchup
Pittsburgh Steelers vs Buffalo Bills
Minnesota Vikings vs Cincinnati Bengals
Seattle Seahawks vs Indianapolis Colts
Philadelphia Eagles vs Atlanta Falcons
Los Angeles Chargers vs Washington Football Team
Arizona Cardinals vs Tennessee Titans
Jacksonville Jaguars vs Houston Texans
New York Jets vs Carolina Panthers
Green Bay Packers vs New Orleans Saints
Denver Broncos vs New York Giants
Miami Dolphins vs New England Patriots
Cleveland Browns vs Kansas City Chiefs
Baltimore Ravens vs Las Vegas Raiders
Chicago Bears vs Los Angeles Rams

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