San Francisco 49ers vs Detroit Lions Odds

The 49ers will play the Lions on Sunday, September 12th, 2021. The matchup takes place at Ford Field. Watch this exciting Week 1 matchup at 1:00 pm EDT. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props. Read the following to understand point spread betting.

BOOK
Bonus
BetRivers Sportsbook#1 BetRivers
REVIEW
$250 Bonus - 100% Match on First Deposit - Code: 250MATCH
Bet Now
21+ Playable in VA only
Gambling Problem? Call 1-888-532-3500
BetMGM Sportsbook#2 BetMGM
REVIEW
First Bet Offer - Up to $1,000 Back in Bonus Bets if You Don't Win
Bet Now
21+ Playable in VA only
Gambling Problem? Call 1-888-532-3500

Point Spread
Underdog

Favorite

Point Spread odds are updating, please check back soon.

Total
OverUnder
Total odds are updating, please check back soon.

Moneyline
Underdog

Favorite

Moneyline odds are updating, please check back soon.

NFL Odds Example

NFL Odds and Outcomes Explained

Game

Bet
8:25pm EDT
TBD VA
VA Odds Pending
No VA Point Spread lines available for this game.

San Francisco 49ers at Detroit Lions Prop Bets

NFL Prop Bets
+ Displays more odds
BetRivers BetRivers
Bet
49ers
Lions
9/12/21 1:00pm EDT
Pending BetRivers

Recent Meetings Since 2017

WeekGameResultMargin
2021
Week 1
49ers vs Lions
Sunday, September 12th, 2021
SF 41, DET 33
Ford Field
49ers by 8
2018
Week 2
Lions vs 49ers
Sunday, September 16th, 2018
SF 30, DET 27
Levi's Stadium
49ers by 3

Team Standings

2021-2022 NFL Regular Season Standings - San Francisco 49ers, Detroit Lions
Team W L Pct PF PA Home Away Div Div% Conf Conf% Strk L5
xy - San Francisco 49ers1070.5884273654-4-06-3-02-4-00.3337-5-00.5832W4-1-0
Detroit Lions3130.2063254673-5-00-8-12-4-00.3333-9-00.2501W2-3-0

Team Stats

San Francisco 49ers Team Stats
Stat San Francisco 49ers Opponents
Total 1st Downs 361 318
Total Offensive Yards 6337 5270
Total Rushing Yards 2161 1760
Total Passing Yards 4437 3510
Sacks 33 48
Field Goals 27 / 32 21 / 27
Touchdowns 50 43
Turnover Ratio -4

Detroit Lions Team Stats
Stat Detroit Lions Opponents
Total 1st Downs 329 372
Total Offensive Yards 5484 6456
Total Rushing Yards 1886 2296
Total Passing Yards 3884 4160
Sacks 36 30
Field Goals 26 / 30 36 / 41
Touchdowns 35 52
Turnover Ratio -4

Team Season Win Totals

The following are each team's season win totals. Learn more about season win totals.

San Francisco 49ers Season Win Total
2022 NFL San Francisco 49ers Season Win Total
+ Displays more odds
BetRivers BetRivers
Bet
49ers
2022 Season Win Total
Detroit Lions Season Win Total
2022 NFL Detroit Lions Season Win Total
+ Displays more odds
BetRivers BetRivers
Bet
Lions
2022 Season Win Total

Team Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds
2024 San Francisco 49ers Super Bowl Winner Odds

Team
BetRivers BetRivers BetMGM BetMGM
49ers
Detroit Lions Futures Odds
2024 Detroit Lions Super Bowl Winner Odds

Team
BetRivers BetRivers BetMGM BetMGM
Lions

2021 San Francisco 49ers Games & Results

WeekMatchupDate & Time
Preseason 1Chiefs vs
49ers
KC 19, SF 16
Saturday, August 14th, 2021
Preseason 249ers vs
Chargers
SF 15, LAC 10
Sunday, August 22nd, 2021
Preseason 3Raiders vs
49ers
SF 34, LV 10
Sunday, August 29th, 2021
Week 149ers vs
Lions
SF 41, DET 33
Sunday, September 12th, 2021
Week 249ers vs
Eagles
SF 17, PHI 11
Sunday, September 19th, 2021
Week 3Packers vs
49ers
GB 30, SF 28
Sunday, September 26th, 2021
Week 4Seahawks vs
49ers
SEA 28, SF 21
Sunday, October 3rd, 2021
Week 549ers vs
Cardinals
ARI 17, SF 10
Sunday, October 10th, 2021
Week 649ers
Bye Week
Week 7Colts vs
49ers
IND 30, SF 18
Sunday, October 24th, 2021
Week 849ers vs
Bears
SF 33, CHI 22
Sunday, October 31st, 2021
Week 9Cardinals vs
49ers
ARI 31, SF 17
Sunday, November 7th, 2021
Week 10Rams vs
49ers
SF 31, LAR 10
Monday, November 15th, 2021
Week 1149ers vs
Jaguars
SF 30, JAX 10
Sunday, November 21st, 2021
Week 12Vikings vs
49ers
SF 34, MIN 26
Sunday, November 28th, 2021
Week 1349ers vs
Seahawks
SEA 30, SF 23
Sunday, December 5th, 2021
Week 1449ers vs
Bengals
SF 26, CIN 23 (OT)
Sunday, December 12th, 2021
Week 15Falcons vs
49ers
SF 31, ATL 13
Sunday, December 19th, 2021
Week 1649ers vs
Titans
TEN 20, SF 17
Thursday, December 23rd, 2021
Week 17Texans vs
49ers
SF 23, HOU 7
Sunday, January 2nd, 2022
Week 1849ers vs
Rams
SF 27, LAR 24 (OT)
Sunday, January 9th, 2022
Wild Card49ers vs
Cowboys
NFC Wild Card Playoffs
SF 23, DAL 17
Sunday, January 16th, 2022
Divisional Round49ers vs
Packers
NFC Divisional Playoffs
SF 13, GB 10
Saturday, January 22nd, 2022
Conference Championship49ers vs
Rams
NFC Championship
LAR 20, SF 17
Sunday, January 30th, 2022

2021 Detroit Lions Games & Results

WeekMatchupDate & Time
Preseason 1Bills vs
Lions
BUF 16, DET 15
Friday, August 13th, 2021
Preseason 2Lions vs
Steelers
PIT 26, DET 20
Saturday, August 21st, 2021
Preseason 3Colts vs
Lions
IND 27, DET 17
Friday, August 27th, 2021
Week 149ers vs
Lions
SF 41, DET 33
Sunday, September 12th, 2021
Week 2Lions vs
Packers
GB 35, DET 17
Monday, September 20th, 2021
Week 3Ravens vs
Lions
BAL 19, DET 17
Sunday, September 26th, 2021
Week 4Lions vs
Bears
CHI 24, DET 14
Sunday, October 3rd, 2021
Week 5Lions vs
Vikings
MIN 19, DET 17
Sunday, October 10th, 2021
Week 6Bengals vs
Lions
CIN 34, DET 11
Sunday, October 17th, 2021
Week 7Lions vs
Rams
LAR 28, DET 19
Sunday, October 24th, 2021
Week 8Eagles vs
Lions
PHI 44, DET 6
Sunday, October 31st, 2021
Week 9Lions
Bye Week
Week 10Lions vs
Steelers
DET 16, PIT 16 (OT)
Sunday, November 14th, 2021
Week 11Lions vs
Browns
CLE 13, DET 10
Sunday, November 21st, 2021
Week 12Bears vs
Lions
CHI 16, DET 14
Thursday, November 25th, 2021
Week 13Vikings vs
Lions
DET 29, MIN 27
Sunday, December 5th, 2021
Week 14Lions vs
Broncos
DEN 38, DET 10
Sunday, December 12th, 2021
Week 15Cardinals vs
Lions
DET 30, ARI 12
Sunday, December 19th, 2021
Week 16Lions vs
Falcons
ATL 20, DET 16
Sunday, December 26th, 2021
Week 17Lions vs
Seahawks
SEA 51, DET 29
Sunday, January 2nd, 2022
Week 18Packers vs
Lions
DET 37, GB 30
Sunday, January 9th, 2022

Other September 12, 2021 NFL Games

Matchup
Pittsburgh Steelers vs
Buffalo Bills
Minnesota Vikings vs
Cincinnati Bengals
Seattle Seahawks vs
Indianapolis Colts
Philadelphia Eagles vs
Atlanta Falcons
Los Angeles Chargers vs
Washington Football Team
Arizona Cardinals vs
Tennessee Titans
Jacksonville Jaguars vs
Houston Texans
New York Jets vs
Carolina Panthers
Green Bay Packers vs
New Orleans Saints
Denver Broncos vs
New York Giants
Miami Dolphins vs
New England Patriots
Cleveland Browns vs
Kansas City Chiefs
Baltimore Ravens vs
Las Vegas Raiders
Chicago Bears vs
Los Angeles Rams
Odds Preview 296