The 49ers will play the Lions on Sunday, September 12th, 2021. The matchup takes place at Ford Field. Watch this exciting Week 1 matchup at 1:00 pm EDT. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Best 49ers at Lions Odds
| Underdog | Favorite |
|---|
| Over | Under |
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| Underdog | Favorite |
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NFL Odds Example
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Game |
Bet |
|---|---|
6:07am EDT | TBD OH,US |
No OH,US Point Spread lines available for this game.
San Francisco 49ers at Detroit Lions Prop Bets
 BetMGMBet |
|
|---|---|
49ers
Lions
9/12/21 1:00pm EDT | Pending BetMGM |
Recent Meetings Since 2017
| Week | Game | Result | Margin |
|---|---|---|---|
| 2023 Conference Championship | Lions vs 49ers Sunday, January 28th, 2024 NFC Championship | SF 34, DET 31 Levi's Stadium | 49ers by 3 |
| 2021 Week 1 | 49ers vs Lions Sunday, September 12th, 2021 | SF 41, DET 33 Ford Field | 49ers by 8 |
| 2018 Week 2 | Lions vs 49ers Sunday, September 16th, 2018 | SF 30, DET 27 Levi's Stadium | 49ers by 3 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xy - San Francisco 49ers | 10 | 7 | 0 | 0.588 | 427 | 365 | 4-4-0 | 6-3-0 | 2-4-0 | 0.333 | 7-5-0 | 0.583 | 2W | 4-1-0 |
| Detroit Lions | 3 | 13 | 1 | 0.206 | 325 | 467 | 3-5-0 | 0-8-1 | 2-4-0 | 0.333 | 3-9-0 | 0.250 | 1W | 2-3-0 |
San Francisco 49ers & Detroit Lions Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
San Francisco 49ers Futures Odds|
Team | BetMGM |
 BetRivers |
|---|---|---|
| 49ers | +600 Bet | +550 Bet |
|
Team | BetMGM |
BetRivers |
|---|---|---|
| Lions | +1200 Bet | +1300 Bet |
San Francisco 49ers & Detroit Lions Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco 49ers vs Detroit Lions NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 12th, 2021 at 1:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Detroit Lions Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Detroit Lions Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.