San Francisco 49ers vs Detroit Lions Odds

The 49ers will play the Lions on Sunday, September 12th, 2021. The matchup takes place at Ford Field. Watch this exciting Week 1 matchup at 1:00 pm EDT. Check local listings for coverage on FOX.

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Recent Meetings Since 2017

WeekGameResultMargin
2021
Wk 1
49ers vs Lions
Sunday, September 12th, 2021
SF 41, DET 33
Ford Field
49ers by 8
2018
Wk 2
Lions vs 49ers
Sunday, September 16th, 2018
SF 30, DET 27
Levi's Stadium
49ers by 3

Regular Season Team Standings

2021 Regular Season Standings
Team Conf Div W L T Pct Home Road Last 5
xy
San Francisco 49ers
7-5-0 2-4-0 10 7 0 0.588 4-4-0 6-3-0 4-1-0
Detroit Lions
3-9-0 2-4-0 3 13 1 0.206 3-5-0 0-8-1 2-3-0

Team Stats

San Francisco 49ers Team Stats
Stat San Francisco 49ers Opponents
Total 1st Downs 361 318
Total Offensive Yards 6387 5270
Total Rushing Yards 2166 1760
Total Passing Yards 4221 3510
Sacks 48 33
Field Goals 27 / 32 21 / 27
Touchdowns 50 43
Avg Time Of Possession 31:09 29:47
Turnover Ratio -4

Detroit Lions Team Stats
Stat Detroit Lions Opponents
Total 1st Downs 329 372
Total Offensive Yards 5484 6456
Total Rushing Yards 1886 2296
Total Passing Yards 3598 4160
Sacks 30 36
Field Goals 26 / 30 36 / 41
Touchdowns 35 52
Avg Time Of Possession 29:12 31:23
Turnover Ratio -4

Team Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds
2023 Super Bowl Winner Odds

Team
BetRivers BetRivers
San Francisco 49ers
Detroit Lions Futures Odds
2023 Super Bowl Winner Odds

Team
BetRivers BetRivers
Detroit Lions

2021 San Francisco 49ers Games & Results

WeekMatchupDate & Time
Pre 2Chiefs vs
49ers
KC 19, SF 16
Saturday, August 14th, 2021
Pre 349ers vs
Chargers
SF 15, LAC 10
Sunday, August 22nd, 2021
Pre 4Raiders vs
49ers
SF 34, LV 10
Sunday, August 29th, 2021
149ers vs
Lions
SF 41, DET 33
Sunday, September 12th, 2021
249ers vs
Eagles
SF 17, PHI 11
Sunday, September 19th, 2021
3Packers vs
49ers
GB 30, SF 28
Sunday, September 26th, 2021
4Seahawks vs
49ers
SEA 28, SF 21
Sunday, October 3rd, 2021
549ers vs
Cardinals
ARI 17, SF 10
Sunday, October 10th, 2021
649ers
Bye Week
7Colts vs
49ers
IND 30, SF 18
Sunday, October 24th, 2021
849ers vs
Bears
SF 33, CHI 22
Sunday, October 31st, 2021
9Cardinals vs
49ers
ARI 31, SF 17
Sunday, November 7th, 2021
10Rams vs
49ers
SF 31, LAR 10
Monday, November 15th, 2021
1149ers vs
Jaguars
SF 30, JAX 10
Sunday, November 21st, 2021
12Vikings vs
49ers
SF 34, MIN 26
Sunday, November 28th, 2021
1349ers vs
Seahawks
SEA 30, SF 23
Sunday, December 5th, 2021
1449ers vs
Bengals
SF 26, CIN 23 (OT)
Sunday, December 12th, 2021
15Falcons vs
49ers
SF 31, ATL 13
Sunday, December 19th, 2021
1649ers vs
Titans
TEN 20, SF 17
Thursday, December 23rd, 2021
17Texans vs
49ers
SF 23, HOU 7
Sunday, January 2nd, 2022
1849ers vs
Rams
SF 27, LAR 24 (OT)
Sunday, January 9th, 2022
Post 149ers vs
Cowboys
Wild Card Playoffs
SF 23, DAL 17
Sunday, January 16th, 2022
Post 249ers vs
Packers
Divisional Playoffs
SF 13, GB 10
Saturday, January 22nd, 2022
Post 349ers vs
Rams
NFC Championship
LAR 20, SF 17
Sunday, January 30th, 2022

2021 Detroit Lions Games & Results

WeekMatchupDate & Time
Pre 2Bills vs
Lions
BUF 16, DET 15
Friday, August 13th, 2021
Pre 3Lions vs
Steelers
PIT 26, DET 20
Saturday, August 21st, 2021
Pre 4Colts vs
Lions
IND 27, DET 17
Friday, August 27th, 2021
149ers vs
Lions
SF 41, DET 33
Sunday, September 12th, 2021
2Lions vs
Packers
GB 35, DET 17
Monday, September 20th, 2021
3Ravens vs
Lions
BAL 19, DET 17
Sunday, September 26th, 2021
4Lions vs
Bears
CHI 24, DET 14
Sunday, October 3rd, 2021
5Lions vs
Vikings
MIN 19, DET 17
Sunday, October 10th, 2021
6Bengals vs
Lions
CIN 34, DET 11
Sunday, October 17th, 2021
7Lions vs
Rams
LAR 28, DET 19
Sunday, October 24th, 2021
8Eagles vs
Lions
PHI 44, DET 6
Sunday, October 31st, 2021
9Lions
Bye Week
10Lions vs
Steelers
DET 16, PIT 16 (OT)
Sunday, November 14th, 2021
11Lions vs
Browns
CLE 13, DET 10
Sunday, November 21st, 2021
12Bears vs
Lions
CHI 16, DET 14
Thursday, November 25th, 2021
13Vikings vs
Lions
DET 29, MIN 27
Sunday, December 5th, 2021
14Lions vs
Broncos
DEN 38, DET 10
Sunday, December 12th, 2021
15Cardinals vs
Lions
DET 30, ARI 12
Sunday, December 19th, 2021
16Lions vs
Falcons
ATL 20, DET 16
Sunday, December 26th, 2021
17Lions vs
Seahawks
SEA 51, DET 29
Sunday, January 2nd, 2022
18Packers vs
Lions
DET 37, GB 30
Sunday, January 9th, 2022

Current NFL Matchup Lines

Next 10 NFL Matchups
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Game
BetRivers BetRivers
Play
Bills
Rams
9/08/22 8:20pm EDT
Saints
Falcons
9/11/22 1:00pm EDT
Jaguars
commanders
9/11/22 1:00pm EDT
Ravens
Jets
9/11/22 1:00pm EDT
Patriots
Dolphins
9/11/22 1:00pm EDT
Colts
Texans
9/11/22 1:00pm EDT
Eagles
Lions
9/11/22 1:00pm EDT
Steelers
Bengals
9/11/22 1:00pm EDT
49ers
Bears
9/11/22 1:00pm EDT
Chiefs
Cardinals
9/11/22 4:25pm EDT
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