The 49ers will play the Lions on Sunday, September 12th, 2021. The matchup takes place at Ford Field. Watch this exciting Week 1 matchup at 1:00 pm EDT. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

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Best 49ers at Lions Odds

**Best Point Spread Betting Odds**
TBD	TBD

Point Spread odds are updating, please check back soon.

**Best Total Betting Odds**
Over	Under

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**Best Moneyline Betting Odds**
TBD	TBD

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NFL Odds Example

NFL Odds and Outcomes Explained
Game	Book

San Francisco 49ers at Detroit Lions Prop Bets

NFL Prop Bets
+ Displays more odds
	BetMGM Bet
49ers Lions 9/12/21 1:00pm EDT	Pending BetMGM

Recent Meetings Since 2017

Recent Meetings Since 2017
Week	Game	Result	Margin
2024 Week 17	Lions vs 49ers Monday, December 30th, 2024	DET 40, SF 34 Levi's Stadium	Lions by 6
2023 Conference Championship	Lions vs 49ers Sunday, January 28th, 2024 NFC Championship	SF 34, DET 31 Levi's Stadium	49ers by 3
2021 Week 1	49ers vs Lions Sunday, September 12th, 2021	SF 41, DET 33 Ford Field	49ers by 8
2018 Week 2	Lions vs 49ers Sunday, September 16th, 2018	SF 30, DET 27 Levi's Stadium	49ers by 3

Team Standings

2021-2022 NFL Regular Season Standings - San Francisco 49ers, Detroit Lions
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xy - San Francisco 49ers	10	7	0	0.588	427	365	4-4-0	6-3-0	2-4-0	0.333	7-5-0	0.583	2W	4-1-0
Detroit Lions	3	13	1	0.206	325	467	3-5-0	0-8-1	2-4-0	0.333	3-9-0	0.250	1W	2-3-0

San Francisco 49ers & Detroit Lions Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds

2025-26 San Francisco 49ers Super Bowl Odds
Team	BetMGM
49ers	+1800 Bet

Detroit Lions Futures Odds

2025-26 Detroit Lions Super Bowl Odds
Team	BetMGM
Lions	+900 Bet

San Francisco 49ers & Detroit Lions Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco 49ers vs Detroit Lions NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 12th, 2021 at 1:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Detroit Lions Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Detroit Lions Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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San Francisco 49ers vs Detroit Lions Odds

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