San Francisco 49ers vs Detroit Lions Odds

The 49ers will play the Lions on Sunday, September 12th, 2021. The matchup takes place at Ford Field. Watch this exciting Week 1 matchup at 1:00 pm EDT. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.


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Table of Contents

Best 49ers at Lions Odds


Best Point Spread Betting Odds
TBDTBD
Point Spread odds are updating, please check back soon.

Best Total Betting Odds
OverUnder
Total odds are updating, please check back soon.

Best Moneyline Betting Odds
TBDTBD
Moneyline odds are updating, please check back soon.

NFL Odds Example

NFL Odds and Outcomes Explained
Game Book

San Francisco 49ers at Detroit Lions Prop Bets

NFL Prop Bets
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Bet
49ers
Lions
9/12/21 1:00pm EDT
Pending BetRivers

Recent Meetings Since 2017

Recent Meetings Since 2017
WeekGameResultMargin
2023
Conference Championship
Lions vs 49ers
Sunday, January 28th, 2024
NFC Championship
SF 34, DET 31
Levi's Stadium
49ers by 3
2021
Week 1
49ers vs Lions
Sunday, September 12th, 2021
SF 41, DET 33
Ford Field
49ers by 8
2018
Week 2
Lions vs 49ers
Sunday, September 16th, 2018
SF 30, DET 27
Levi's Stadium
49ers by 3

Team Standings

2023-2024 NFL Regular Season Standings - San Francisco 49ers, Detroit Lions
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
xz - Detroit Lions12500.7064613956-2-06-3-04-2-00.6678-4-00.6671W3-2-0
xz* - San Francisco 49ers12500.7064912985-3-07-2-05-1-00.83310-2-00.8331L3-2-0

San Francisco 49ers & Detroit Lions Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds
2024-25 San Francisco 49ers Super Bowl Odds

Team
BetRivers Sports Betting BetRivers BetMGM Sports Betting BetMGM
49ers
+600
Bet
+600
Bet
Detroit Lions Futures Odds
2024-25 Detroit Lions Super Bowl Odds

Team
BetRivers Sports Betting BetRivers BetMGM Sports Betting BetMGM
Lions
+1300
Bet
+1200
Bet

San Francisco 49ers & Detroit Lions Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco 49ers vs Detroit Lions NFL Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 12th, 2021 at 1:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Detroit Lions Game.

    Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Detroit Lions Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other September 12, 2021 NFL Games

Matchup
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Buffalo Bills
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Cincinnati Bengals
Seattle Seahawks vs
Indianapolis Colts
Philadelphia Eagles vs
Atlanta Falcons
Los Angeles Chargers vs
Washington Football Team
Arizona Cardinals vs
Tennessee Titans
Jacksonville Jaguars vs
Houston Texans
New York Jets vs
Carolina Panthers
Green Bay Packers vs
New Orleans Saints
Denver Broncos vs
New York Giants
Miami Dolphins vs
New England Patriots
Cleveland Browns vs
Kansas City Chiefs
Baltimore Ravens vs
Las Vegas Raiders
Chicago Bears vs
Los Angeles Rams
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