San Francisco 49ers vs Detroit Lions NFL Betting Lines

Odds Preview 296

The 49ers will play the Lions on Sunday, September 12th, 2021. The matchup takes place at Ford Field. Watch this exciting week 1 matchup at 1:00 pm on FOX.

Best Underdog and Favorite Spread Bets
Underdog
Detroit Lions
Detroit Lions
Favorite
San Francisco 49ers
San Francisco 49ers
+9 -109 Sb3gen1 -9 -105 Sb3gen3
+9 -110 Sb3gen2 -9 -110 Sb3gen2
+9 -115 Sb3gen3 -9 -111 Sb3gen1
SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Sunday. Sb3gen3 has the best favorite San Francisco 49ers spread at -9 points. Sb3gen1 has the best underdog Detroit Lions spread at +9 points.

Review our point spread betting tutorial and video for more information.
Best Over and Under Total Lines
OverUnder
46o -110 Sb3gen2 46u -107 Sb3gen1
46o -110 Sb3gen3 46u -110 Sb3gen2
46o -113 Sb3gen1 46u -110 Sb3gen3
The over under line estimates the combined total of each team's final score. Sb3gen2 has the best over line of 46 points laying $110 to win $100. Sb3gen1 has the best under line of 46 u -107.
Best Money Line Bets
Underdog
Detroit Lions
Detroit Lions
Favorite
San Francisco 49ers
San Francisco 49ers
+325 Sb3gen3 -400 Sb3gen1
+320 Sb3gen1 -420 Sb3gen2
+315 Sb3gen2 -425 Sb3gen3
Here are money lines for the outright winner. Favorite San Francisco 49ers has a minus value. Lay $400 at Sb3gen1 to win $100. Underdog Detroit Lions has a positive value. Risk $100 at Sb3gen3 to win $325.

San Francisco 49ers vs Detroit Lions Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

San Francisco 49ers Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
San Francisco 49ersSan Francisco 49ers

Cached 2021-09-20 16:32:19
Detroit Lions Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
Detroit LionsDetroit Lions

Cached 2021-09-20 16:32:19

Team Stats

2021 San Francisco 49ers Team Stats
Stat San Francisco 49ers Opponents
Total 1st Downs 44 49
Total Offensive Yards 748 758
Total Rushing Yards 248 267
Total Passing Yards 500 491
Sacks 5 1
Field Goals 3 / 4 2 / 4
Touchdowns 7 5
Avg Time Of Possession 30:43 29:16
Turnover Ratio -1

2021 Detroit Lions Team Stats
Stat Detroit Lions Opponents
Total 1st Downs 31 21
Total Offensive Yards 430 442
Total Rushing Yards 116 131
Total Passing Yards 314 311
Sacks 1 3
Field Goals 1 / 2 2 / 3
Touchdowns 4 5
Avg Time Of Possession 33:27 26:33
Turnover Ratio +1


Team Standings

2021 Regular Season Standings
Team Conf Div W L T Pct Home Road Last 5
Detroit LionsSan Francisco 49ers 2-0-0 0-0-0 2 0 0 1.000 0-0-0 2-0-0 2-0-0
Detroit LionsDetroit Lions 0-1-0 0-0-0 0 1 0 0.000 0-1-0 0-0-0 0-1-0

2021 San Francisco 49ers Games & Results

Bye Week: 6
WeekMatchupDate & Time
1 49ers vs
Lions
SF 41, DET 33
09/12/2021
2 49ers vs
Eagles
SF 17, PHI 11
09/19/2021
3 Packers vs
49ers
09/26/2021
8:20PM
4 Seahawks vs
49ers
10/03/2021
4:05PM
5 49ers vs
Cardinals
10/10/2021
4:25PM
6San Francisco 49ers ByeN/A
7 Colts vs
49ers
10/24/2021
8:20PM
8 49ers vs
Bears
10/31/2021
1:00PM
9 Cardinals vs
49ers
11/07/2021
4:25PM
10 Rams vs
49ers
11/15/2021
8:15PM
11 49ers vs
Jaguars
11/21/2021
1:00PM
12 Vikings vs
49ers
11/28/2021
4:25PM
13 49ers vs
Seahawks
12/05/2021
8:20PM
14 49ers vs
Bengals
12/12/2021
1:00PM
15 Falcons vs
49ers
12/19/2021
4:05PM
16 49ers vs
Titans
12/23/2021
8:20PM
17 Texans vs
49ers
01/02/2022
4:05PM

2021 Detroit Lions Games & Results

Bye Week: 9
WeekMatchupDate & Time
1 49ers vs
Lions
SF 41, DET 33
09/12/2021
2 Lions vs
Packers
09/20/2021
8:15PM
3 Ravens vs
Lions
09/26/2021
1:00PM
4 Lions vs
Bears
10/03/2021
1:00PM
5 Lions vs
Vikings
10/10/2021
1:00PM
6 Bengals vs
Lions
10/17/2021
1:00PM
7 Lions vs
Rams
10/24/2021
4:05PM
8 Eagles vs
Lions
10/31/2021
1:00PM
9Detroit Lions ByeN/A
10 Lions vs
Steelers
11/14/2021
1:00PM
11 Lions vs
Browns
11/21/2021
1:00PM
12 Bears vs
Lions
11/25/2021
12:30PM
13 Vikings vs
Lions
12/05/2021
1:00PM
14 Lions vs
Broncos
12/12/2021
4:05PM
15 Cardinals vs
Lions
12/19/2021
1:00PM
16 Lions vs
Falcons
12/26/2021
1:00PM
17 Lions vs
Seahawks
01/02/2022
4:25PM

Other 2021 Week 1 Matchups

MatchupDate & Time
Cowboys vs
Buccaneers
TB 31, DAL 29
09/09/2021
Eagles vs
Falcons
PHI 32, ATL 6
09/12/2021
Steelers vs
Bills
PIT 23, BUF 16
09/12/2021
Vikings vs
Bengals
CIN 27, MIN 24 (OT)
09/12/2021
49ers vs
Lions
SF 41, DET 33
09/12/2021
Cardinals vs
Titans
ARI 38, TEN 13
09/12/2021
Seahawks vs
Colts
SEA 28, IND 16
09/12/2021
Chargers vs
TBD
LAC 20, WSH 16
09/12/2021
Jets vs
Panthers
CAR 19, NYJ 14
09/12/2021
Jaguars vs
Texans
HOU 37, JAX 21
09/12/2021
Browns vs
Chiefs
KC 33, CLE 29
09/12/2021
Dolphins vs
Patriots
MIA 17, NE 16
09/12/2021
Packers vs
Saints
NO 38, GB 3
09/12/2021
Broncos vs
Giants
DEN 27, NYG 13
09/12/2021
Bears vs
Rams
LAR 34, CHI 14
09/12/2021
Ravens vs
Raiders
LV 33, BAL 27 (OT)
09/13/2021