San Francisco 49ers vs Houston Texans Odds

The 49ers will play the Texans on Sunday, October 26th, 2025. The matchup takes place at NRG Stadium. Watch this exciting Week 8 matchup at 1:00 pm EDT. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.


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Table of Contents

Key Matchup Stats

The San Francisco 49ers and Houston Texans will take the field at NRG Stadium for a key Week 8 matchup on Sunday, October 26th, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.

  • SportsBetting3.com Power Rankings - Heading into Week 8 of the 2025-26 season, the San Francisco 49ers have a power ranking of 94.33. Our calculations have the Houston Texans at a 94.67 power ranking.
  • Away San Francisco 49ers - Now in the middle of the season, the San Francisco 49ers have a 3-1-0 record as an away team, ranking them 2nd in the league for away team wins.
  • Home Houston Texans - The Houston Texans come to this Week 8 matchup with a 1-1-0 record as a home team. They rank 4th in the league for home team wins so far this season.
  • Points Scored - The San Francisco 49ers currently rank 19th (145) on the edge of Week 8, with the Houston Texans ranked 24th (127) for points scored to date.
  • Points Against - The San Francisco 49ers stand 19th (138) in the middle weeks of the regular season for points against. As for the Houston Texans, they currently rank 28th (88) for points against.
  • Team Records - Standings become more important now more than ever. Approaching Week 8, the San Francisco 49ers have a 5-2-0 record, with the Houston Texans at 2-4-0 for the 2025-26 regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast ye, me hearties! The San Francisco 49ers be facing the Houston Texans on Sunday! The 49ers be comin' in with a strong 5-2-0 record, while the Texans be strugglin' at 2-4-0. These mid-season games be crucial for each team's playoff hopes!

This Week 8 showdown be takin' place at the grand NRG Stadium in Houston. The city o' Houston be known for its vibrant culture and love for football! The atmosphere at NRG Stadium be electric, arrr!

According to the SportsBetting3.com NFL Power Rankings, the 49ers be slightly behind the Texans. Ye can bet this game at BetMGM or our preferred sports betting partner BetRivers. Look at this game's prop bets and compare odds from partner sports betting sites, me hearties! Arrr!

Best 49ers at Texans Odds


Best Point Spread Betting Odds
Underdog

San Francisco 49ers
Favorite

Houston Texans
The Houston Texans have a -2.5 -110 point spread at BetMGM OH. They are the point spread favorite in this matchup. The San Francisco 49ers have a +2.5 -110 point spread at BetMGM OH. The San Francisco 49ers are the point spread underdogs. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 42 points. Risk $110 to win $100. BetMGM has the best under line of 42 points. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

San Francisco 49ers
Favorite

Houston Texans
The Houston Texans are the -130 moneyline favorite. Risk $130 to win $100 on the Houston Texans at BetMGM. The San Francisco 49ers are the +110 underdog at BetMGM. Risk $100 to win $110 on the San Francisco 49ers. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the San Francisco 49ers vs Houston Texans NFL game on Sunday, October 26th, 2025?

The Houston Texans are -2.5 -110 point spread favorites at BetMGM, while the San Francisco 49ers are +2.5 -110 point spread underdogs at BetMGM.

What is the over-under total line for the San Francisco 49ers vs Houston Texans NFL game on Sunday, October 26th, 2025?

The best over line is 42 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 42 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the San Francisco 49ers vs Houston Texans NFL game on Sunday, October 26th, 2025?

The Houston Texans are the -130 moneyline favorite at BetMGM and the San Francisco 49ers are the +110 moneyline underdog at BetMGM.

NFL Odds Example

NFL Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
49ers
Texans
10/26/25 1:00pm EDT
+2.5 -110-2.5 -110
Bet $100 at BetMGM Ohio
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Gambling Problem? Call 1-800-589-9966

Underdog San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $90.91 at -110 odds.

A +2.5 San Francisco 49ers underdog bet wins if they lose by 2 or fewer, tie, or win outright. Your bet loses if they lose by 3 or more.

Favorite Houston Texans - Houston Texans bettors risk $100 to win $90.91 at -110 odds.

A -2.5 Houston Texans favorite bet wins if they win by 3 or more. Your bet loses if they win by 2 or fewer, tie, or lose outright.

San Francisco 49ers at Houston Texans Prop Bets

NFL Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
49ers
Texans
First Team To Score
10/26/25 1:00pm EDT
-105-120Bet
49ers
Texans
No Touchdown
To Score 1st Touchdown
10/26/25 1:00pm EDT
-102-130+6600Bet
49ers
Texans
Game to Overtime
10/26/25 1:00pm EDT
Yes +725No -2500Bet
49ers
Texans
Safety to be Scored
10/26/25 1:00pm EDT
Yes +1000No -3000Bet
BetMGM Sports Betting BetMGM
CJ Stroud
Interceptions Thrown
SF at HOU
10/26/25 1:00pm EDT
0.5 o -1050.5 u -130Bet
Mac Jones
Interceptions Thrown
SF at HOU
10/26/25 1:00pm EDT
0.5 o -1400.5 u +105Bet
CJ Stroud
Longest Passing Completion
SF at HOU
10/26/25 1:00pm EDT
33.5 o -11033.5 u -120Bet
Mac Jones
Longest Passing Completion
SF at HOU
10/26/25 1:00pm EDT
34.5 o -11034.5 u -120Bet
BetMGM Sports Betting BetMGM
Eddy Pineiro
Total Kicking Points
SF at HOU
10/26/25 1:00pm EDT
7.5 o +1007.5 u -135Bet
Ka'imi Fairbairn
Total Kicking Points
SF at HOU
10/26/25 1:00pm EDT
7.5 o -1307.5 u +100Bet
CJ Stroud
Total Pass Completions
SF at HOU
10/26/25 1:00pm EDT
21.5 o -11021.5 u -120Bet
Mac Jones
Total Pass Completions
SF at HOU
10/26/25 1:00pm EDT
21.5 o -10521.5 u -125Bet
BetMGM Sports Betting BetMGM
CJ Stroud
Total Passing Yards
SF at HOU
10/26/25 1:00pm EDT
214.5 o -115214.5 u -115Bet
Mac Jones
Total Passing Yards
SF at HOU
10/26/25 1:00pm EDT
228.5 o -115228.5 u -115Bet
CJ Stroud
Total Touchdown Passes
SF at HOU
10/26/25 1:00pm EDT
1.5 o +1101.5 u -150Bet
Mac Jones
Total Touchdown Passes
SF at HOU
10/26/25 1:00pm EDT
1.5 o +1551.5 u -210Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
WeekGameResultMargin
2025
Week 8
49ers vs Texans
Sunday, October 26th, 2025
HOU 26, SF 15
NRG Stadium
Texans by 11
2022
Preseason Week 3
49ers vs Texans
Thursday, August 25th, 2022
HOU 17, SF 0
NRG Stadium
Texans by 17
2021
Week 17
Texans vs 49ers
Sunday, January 2nd, 2022
SF 23, HOU 7
Levi's Stadium
49ers by 16

Team Standings

2025-2026 NFL Regular Season Standings - San Francisco 49ers, Houston Texans
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
San Francisco 49ers9400.6923072693-2-06-2-04-1-00.8008-2-00.8003W4-1-0
Houston Texans7500.5832631984-2-03-3-04-1-00.8006-2-00.7504W4-1-0

San Francisco 49ers & Houston Texans Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds
2025-26 San Francisco 49ers Super Bowl Odds

Team
BetMGM Sports Betting BetMGM
49ers
+2500
Bet
Houston Texans Futures Odds
2025-26 Houston Texans Super Bowl Odds

Team
BetMGM Sports Betting BetMGM
Texans
+3000
Bet

San Francisco 49ers & Houston Texans Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco 49ers vs Houston Texans NFL Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Sunday, October 26th, 2025 at 1:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Houston Texans Game.

    Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Houston Texans Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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