The Bills will play the Panthers on Sunday, October 26th, 2025. The matchup takes place at Bank of America Stadium. Watch this exciting Week 8 matchup at 1:03 pm EDT. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The Buffalo Bills and Carolina Panthers will take the field at Bank of America Stadium for a key Week 8 matchup on Sunday, October 26th, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.
- SportsBetting3.com Power Rankings - Heading into Week 8 of the 2025-26 season, the Buffalo Bills have a power ranking of 94.67. Our calculations have the Carolina Panthers at a 92.67 power ranking.
- Away Buffalo Bills - Now in the middle of the season, the Buffalo Bills have a 1-1-0 record as an away team, ranking them 4th in the league for away team wins.
- Home Carolina Panthers - The Carolina Panthers come to this Week 8 matchup with a 3-0-0 record as a home team. They rank 2nd in the league for home team wins so far this season.
- Points Scored - The Buffalo Bills currently rank 9th (167) on the edge of Week 8, with the Carolina Panthers ranked 19th (145) for points scored to date.
- Points Against - The Buffalo Bills stand 20th (137) in the middle weeks of the regular season for points against. As for the Carolina Panthers, they currently rank 15th (152) for points against.
- Team Records - Standings become more important now more than ever. Approaching Week 8, the Buffalo Bills have a 4-2-0 record, with the Carolina Panthers at 4-3-0 for the 2025-26 regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Arrr, the Buffalo Bills be takin' on the Carolina Panthers in an important Week 8 matchup. Buffalo Bills be standin' at 4-2-0, while Carolina Panthers be standin' at 4-3-0. Mid-season games be crucial for each team's standings.
The battle be happenin' at Bank of America Stadium, a place full of city life and culture. The fans be rowdy, cheerin' on their team with all their might.
According to SportsBetting3.com NFL Power Rankings, Buffalo Bills be at 94.67, while Carolina Panthers be at 92.67. Bet this game at BetMGM or our preferred sports betting partner BetRivers, and look at this game's prop bets. Compare odds from partner sports betting sites to make yer wager wisely. Arrr!
Best Bills at Panthers Odds
| Underdog Carolina Panthers | Favorite Buffalo Bills |
|---|---|
| Over | Under |
|---|---|
| Underdog Carolina Panthers | Favorite Buffalo Bills |
|---|---|
Matchup Odds FAQs
The Buffalo Bills are -10.5 -118 point spread favorites at BetRivers, while the Carolina Panthers are +10.5 -118 point spread underdogs at BetRivers.
The best over line is 46.5 -118 points at BetRivers, which means you risk $118 to win $100 betting the over. The best under line is 46.5 -120 points at BetRivers, and that means you risk $120 to win $100 betting the under.
The Buffalo Bills are the -625 moneyline favorite at BetRivers and the Carolina Panthers are the +370 moneyline underdog at BetRivers.
NFL Odds Example
|
Game |
 BetRiversBet |
|---|---|
Bills
Panthers
10/26/25 1:03pm EDT | -10.5 -118+10.5 -118 |
Underdog Carolina Panthers - Carolina Panthers bettors risk $100 to win $84.75 at -118 odds.
A +10.5 Carolina Panthers underdog bet wins if they lose by 10 or fewer, tie, or win outright. Your bet loses if they lose by 11 or more.
Favorite Buffalo Bills - Buffalo Bills bettors risk $100 to win $84.75 at -118 odds.
A -10.5 Buffalo Bills favorite bet wins if they win by 11 or more. Your bet loses if they win by 10 or fewer, tie, or lose outright.
Buffalo Bills at Carolina Panthers Prop Bets
| BetRivers Bet |
|
|---|---|
Bills
Panthers
First Field Goal
10/26/25 1:03pm EDT | -360+210Bet |
Bills
Panthers
First Team To Score
10/26/25 1:03pm EDT | -175+133Bet |
Bills
Panthers
Tie
First to 15 Points
10/26/25 1:03pm EDT | -590+350+2400Bet |
Bills
Panthers
Tie
First to 20 Points
10/26/25 1:03pm EDT | -420+390+800Bet |
| BetRivers | |
Bills
Panthers
Safety to be Scored
10/26/25 1:03pm EDT | Yes +1600No -5000Bet |
Bills
Team Total Points
BUF at CAR 10/26/25 1:03pm EDT | 27.5 o -10927.5 u -112Bet |
Panthers
Team Total Points
BUF at CAR 10/26/25 1:03pm EDT | 18.5 o -11518.5 u -106Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2026 Preseason Week 1 | Panthers vs Bills Saturday, August 15th, 2026 | BUF 29, CAR 14 Highmark Stadium | Bills by 15 |
| 2025 Week 8 | Bills vs Panthers Sunday, October 26th, 2025 | BUF 40, CAR 9 Bank of America Stadium | Bills by 31 |
| 2024 Preseason Week 3 | Panthers vs Bills Saturday, August 24th, 2024 | CAR 31, BUF 26 Highmark Stadium | Panthers by 5 |
| 2022 Preseason Week 3 | Bills vs Panthers Friday, August 26th, 2022 | CAR 21, BUF 0 Bank of America Stadium | Panthers by 21 |
| 2021 Week 15 | Panthers vs Bills Sunday, December 19th, 2021 | BUF 31, CAR 14 Highmark Stadium | Bills by 17 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xy - Buffalo Bills | 12 | 5 | 0 | 0.706 | 481 | 365 | 7-2-0 | 5-3-0 | 4-2-0 | 0.667 | 9-3-0 | 0.750 | 1W | 4-1-0 |
| xz - Carolina Panthers | 8 | 9 | 0 | 0.471 | 311 | 380 | 5-3-0 | 3-6-0 | 3-3-0 | 0.500 | 6-6-0 | 0.500 | 2L | 2-3-0 |
Buffalo Bills & Carolina Panthers Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Buffalo Bills Futures Odds|
Team | BetRivers |
|---|---|
| Bills | +700 Bet |
|
Team | BetRivers |
|---|---|
| Panthers | +10000 Bet |
Buffalo Bills & Carolina Panthers Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Buffalo Bills vs Carolina Panthers NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, October 26th, 2025 at 1:03 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Buffalo Bills vs Carolina Panthers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Buffalo Bills vs Carolina Panthers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other October 26, 2025 NFL Games
- New York Giants vs Philadelphia Eagles
- Cleveland Browns vs New England Patriots
- San Francisco 49ers vs Houston Texans
- Miami Dolphins vs Atlanta Falcons
- Chicago Bears vs Baltimore Ravens
- New York Jets vs Cincinnati Bengals
- Tampa Bay Buccaneers vs New Orleans Saints
- Tennessee Titans vs Indianapolis Colts
- Dallas Cowboys vs Denver Broncos
- Green Bay Packers vs Pittsburgh Steelers