The Buccaneers will play the Bills on Sunday, November 16th, 2025. The matchup takes place at Highmark Stadium. Watch this exciting Week 11 matchup at 1:00 pm EST. Check local listings for coverage on CBS.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
Rolling into Week 11, the Tampa Bay Buccaneers and Buffalo Bills will matchup on Sunday, November 16th, 2025 at Highmark Stadium for an important mid-season game. We've compiled some key performance stats below to help you handicap this matchup. Now that the 2025-26 NFL regular season is half over, teams need to sharpen their performance with an eye for the January playoffs.
- SportsBetting3.com Power Rankings - As of Week 11 of the 2025-26 season, the Tampa Bay Buccaneers have a power ranking of 93.33. Our formula has the Buffalo Bills at a 94.67 power ranking.
- Away Tampa Bay Buccaneers - With the season now half over, the Tampa Bay Buccaneers have a 4-1-0 record as an away team, ranking them 2nd in the league for away team wins.
- Home Buffalo Bills - The Buffalo Bills start this Week 11 matchup with a 4-1-0 record as a home team. They rank 3rd in the league for home team wins so far in the 2025-26 regular season.
- Points Scored - The Tampa Bay Buccaneers currently rank 13th (220) looking at Week 11, with the Buffalo Bills ranked 7th (248) for points scored to date.
- Points Against - The Tampa Bay Buccaneers stand 18th (206) now halfway through the regular season for points against. Meanwhile the Buffalo Bills currently rank 21st (197) for points against.
- Team Records - The second half of the season is make or break. Heading into Week 11, the Tampa Bay Buccaneers have a 6-3-0 record, with the Buffalo Bills at 6-3-0 for the 2025-26 regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Arrr, ye scurvy dogs! The Buccaneers be facin' the Bills in a crucial Week 11 battle.
The season be halfway through, and every win be crucial for makin' the playoffs.
The game be happenin' at Highmark Stadium, in the heart of Buffalo's fierce culture. Buccaneers be rankin' at 93.33, while the Bills be at 94.67. I recommend betting on this game at BetRivers, or BetMGM, review this matchup's prop bets below, look at the odds from our partner sportsbooks.
Best Buccaneers at Bills Odds
| Underdog Tampa Bay Buccaneers | Favorite Buffalo Bills |
|---|---|
| Over | Under |
|---|---|
| Underdog Tampa Bay Buccaneers | Favorite Buffalo Bills |
|---|---|
Matchup Odds FAQs
The Buffalo Bills are -6 -110 point spread favorites at BetMGM, while the Tampa Bay Buccaneers are +6 -110 point spread underdogs at BetMGM.
The best over line is 47 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 47 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The Buffalo Bills are the -275 moneyline favorite at BetMGM and the Tampa Bay Buccaneers are the +225 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
Buccaneers
Bills
11/16/25 1:00pm EST | +6 -110-6 -110 |
Underdog Tampa Bay Buccaneers - Tampa Bay Buccaneers bettors risk $100 to win $90.91 at -110 odds.
A +6 Tampa Bay Buccaneers underdog bet wins if they lose by 5 or fewer, tie, or win outright. The bet pushes if they lose by 6. Your bet loses if they lose by 7 or more.
Favorite Buffalo Bills - Buffalo Bills bettors risk $100 to win $90.91 at -110 odds.
A -6 Buffalo Bills favorite bet wins if they win by 7 or more. The bet pushes if they win by 6. Your bet loses if they win by 5 or fewer, tie, or lose outright.
Tampa Bay Buccaneers at Buffalo Bills Prop Bets
| BetMGM Bet |
|
|---|---|
Buccaneers
Bills
First Team To Score
11/16/25 1:00pm EST | +110-140Bet |
Buccaneers
Bills
No Touchdown
To Score 1st Touchdown
11/16/25 1:00pm EST | +125-165+10000Bet |
Buccaneers
Bills
Game to Overtime
11/16/25 1:00pm EST | Yes +775No -2500Bet |
Buccaneers
Bills
Safety to be Scored
11/16/25 1:00pm EST | Yes +1000No -3000Bet |
| BetMGM | |
Baker Mayfield
Interceptions Thrown
TB at BUF 11/16/25 1:00pm EST | 0.5 o -1050.5 u -125Bet |
Josh Allen
Interceptions Thrown
TB at BUF 11/16/25 1:00pm EST | 0.5 o +1100.5 u -145Bet |
Baker Mayfield
Longest Passing Completion
TB at BUF 11/16/25 1:00pm EST | 33.5 o -11033.5 u -120Bet |
Josh Allen
Longest Passing Completion
TB at BUF 11/16/25 1:00pm EST | 34.5 o -12034.5 u -110Bet |
| BetMGM | |
Chase McLaughlin
Total Kicking Points
TB at BUF 11/16/25 1:00pm EST | 6.5 o +1006.5 u -135Bet |
Matt Prater
Total Kicking Points
TB at BUF 11/16/25 1:00pm EST | 6.5 o -1356.5 u +100Bet |
Baker Mayfield
Total Pass Completions
TB at BUF 11/16/25 1:00pm EST | 20.5 o +10020.5 u -135Bet |
Josh Allen
Total Pass Completions
TB at BUF 11/16/25 1:00pm EST | 19.5 o -11019.5 u -120Bet |
| BetMGM | |
Baker Mayfield
Total Passing Yards
TB at BUF 11/16/25 1:00pm EST | 206.5 o -115206.5 u -115Bet |
Josh Allen
Total Passing Yards
TB at BUF 11/16/25 1:00pm EST | 216.5 o -115216.5 u -118Bet |
Baker Mayfield
Total Touchdown Passes
TB at BUF 11/16/25 1:00pm EST | 1.5 o +1151.5 u -150Bet |
Josh Allen
Total Touchdown Passes
TB at BUF 11/16/25 1:00pm EST | 1.5 o +1101.5 u -145Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 11 | Buccaneers vs Bills Sunday, November 16th, 2025 | BUF 44, TB 32 Highmark Stadium | Bills by 12 |
| 2025 Preseason Week 3 | Bills vs Buccaneers Saturday, August 23rd, 2025 | BUF 23, TB 19 Raymond James Stadium | Bills by 4 |
| 2023 Week 8 | Buccaneers vs Bills Thursday, October 26th, 2023 | BUF 24, TB 18 Highmark Stadium | Bills by 6 |
| 2021 Week 14 | Bills vs Buccaneers Sunday, December 12th, 2021 | TB 33, BUF 27 (OT) Raymond James Stadium | Buccaneers by 6 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buffalo Bills | 8 | 4 | 0 | 0.667 | 337 | 259 | 5-1-0 | 3-3-0 | 2-2-0 | 0.500 | 5-3-0 | 0.625 | 1W | 3-2-0 |
| Tampa Bay Buccaneers | 7 | 5 | 0 | 0.583 | 279 | 301 | 3-2-0 | 4-3-0 | 2-0-0 | 1.000 | 5-3-0 | 0.625 | 1W | 2-3-0 |
Tampa Bay Buccaneers & Buffalo Bills Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Tampa Bay Buccaneers Futures Odds|
Team | BetMGM |
|---|---|
| Buccaneers | +4000 Bet |
|
Team | BetMGM |
|---|---|
| Bills | +1000 Bet |
Tampa Bay Buccaneers & Buffalo Bills Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Tampa Bay Buccaneers vs Buffalo Bills NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, November 16th, 2025 at 1:00 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Tampa Bay Buccaneers vs Buffalo Bills Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Tampa Bay Buccaneers vs Buffalo Bills Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other November 16, 2025 NFL Games
- Washington Commanders vs Miami Dolphins - 11/16/25 9:30am EST
- Los Angeles Chargers vs Jacksonville Jaguars - 11/16/25 1:00pm EST
- Houston Texans vs Tennessee Titans - 11/16/25 1:00pm EST
- Cincinnati Bengals vs Pittsburgh Steelers - 11/16/25 1:00pm EST
- Chicago Bears vs Minnesota Vikings - 11/16/25 1:00pm EST
- Green Bay Packers vs New York Giants - 11/16/25 1:03pm EST
- Carolina Panthers vs Atlanta Falcons - 11/16/25 1:03pm EST
- San Francisco 49ers vs Arizona Cardinals - 11/16/25 4:05pm EST
- Seattle Seahawks vs Los Angeles Rams - 11/16/25 4:05pm EST
- Kansas City Chiefs vs Denver Broncos - 11/16/25 4:25pm EST
- Baltimore Ravens vs Cleveland Browns - 11/16/25 4:25pm EST
- Detroit Lions vs Philadelphia Eagles - 11/16/25 8:20pm EST