San Francisco 49ers vs Arizona Cardinals NFL Betting Lines

Odds Preview 414

The 49ers will play the Cardinals on Sunday, October 10th, 2021. The matchup takes place at State Farm Stadium. Watch this exciting week 5 matchup at 4:25 pm on FOX.

Best Underdog and Favorite Spread Bets
Underdog

San Francisco 49ers
Favorite

Arizona Cardinals
+5.5 -110 Sb3gen3 -5 -110 Sb3gen2
+5 -105 Sb3gen1 -5 -115 Sb3gen1
+5 -110 Sb3gen2 -5.5 -110 Sb3gen3
SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Sunday. Sb3gen2 has the best favorite Arizona Cardinals spread at -5 points. Sb3gen3 has the best underdog San Francisco 49ers spread at +5.5 points.

Review our point spread betting tutorial and video for more information.
Best Over and Under Total Lines
OverUnder
48o -115 Sb3gen2 48.5u -110 Sb3gen3
48.5o -107 Sb3gen1 48.5u -113 Sb3gen1
48.5o -110 Sb3gen3 48u -105 Sb3gen2
The over under line estimates the combined total of each team's final score. Sb3gen2 has the best over line of 48 points laying $115 to win $100. Sb3gen3 has the best under line of 48.5 u -110.
Best Money Line Bets
Underdog

San Francisco 49ers
Favorite

Arizona Cardinals
+205 Sb3gen1 -245 Sb3gen1
+205 Sb3gen2 -245 Sb3gen2
+205 Sb3gen3 -255 Sb3gen3
Here are money lines for the outright winner. Favorite Arizona Cardinals has a minus value. Lay $245 at Sb3gen1 to win $100. Underdog San Francisco 49ers has a positive value. Risk $100 at Sb3gen1 to win $205.

San Francisco 49ers vs Arizona Cardinals Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

San Francisco 49ers Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
San Francisco 49ers

Cached 2021-10-24 16:56:04
Arizona Cardinals Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
Arizona Cardinals

Cached 2021-10-24 16:56:04

Team Stats

2021 San Francisco 49ers Team Stats
Stat San Francisco 49ers Opponents
Total 1st Downs 112 104
Total Offensive Yards 1841 1649
Total Rushing Yards 610 566
Total Passing Yards 1231 1083
Sacks 11 9
Field Goals 4 / 6 6 / 9
Touchdowns 15 14
Avg Time Of Possession 30:58 29:01
Turnover Ratio -5

2021 Arizona Cardinals Team Stats
Stat Arizona Cardinals Opponents
Total 1st Downs 137 118
Total Offensive Yards 2418 2057
Total Rushing Yards 784 768
Total Passing Yards 1634 1289
Sacks 17 12
Field Goals 11 / 14 5 / 8
Touchdowns 23 14
Avg Time Of Possession 32:40 27:19
Turnover Ratio +8


Team Standings

2021 Regular Season Standings
Team Conf Div W L T Pct Home Road Last 5
San Francisco 49ers 2-3-0 0-2-0 2 3 0 0.400 0-2-0 2-1-0 2-3-0
Arizona Cardinals 3-0-0 2-0-0 6 0 0 1.000 2-0-0 4-0-0 5-0-0

2021 San Francisco 49ers Games & Results

Bye Week: 6
WeekMatchupDate & Time
1 49ers vs
Lions
SF 41, DET 33
09/12/2021
2 49ers vs
Eagles
SF 17, PHI 11
09/19/2021
3 Packers vs
49ers
GB 30, SF 28
09/26/2021
4 Seahawks vs
49ers
SEA 28, SF 21
10/03/2021
5 49ers vs
Cardinals
ARI 17, SF 10
10/10/2021
6San Francisco 49ers ByeN/A
7 Colts vs
49ers
10/24/2021
8:20PM
8 49ers vs
Bears
10/31/2021
1:00PM
9 Cardinals vs
49ers
11/07/2021
4:25PM
10 Rams vs
49ers
11/15/2021
8:15PM
11 49ers vs
Jaguars
11/21/2021
1:00PM
12 Vikings vs
49ers
11/28/2021
4:25PM
13 49ers vs
Seahawks
12/05/2021
8:20PM
14 49ers vs
Bengals
12/12/2021
1:00PM
15 Falcons vs
49ers
12/19/2021
4:05PM
16 49ers vs
Titans
12/23/2021
8:20PM
17 Texans vs
49ers
01/02/2022
4:05PM

2021 Arizona Cardinals Games & Results

Bye Week: 12
WeekMatchupDate & Time
1 Cardinals vs
Titans
ARI 38, TEN 13
09/12/2021
2 Vikings vs
Cardinals
ARI 34, MIN 33
09/19/2021
3 Cardinals vs
Jaguars
ARI 31, JAX 19
09/26/2021
4 Cardinals vs
Rams
ARI 37, LAR 20
10/03/2021
5 49ers vs
Cardinals
ARI 17, SF 10
10/10/2021
6 Cardinals vs
Browns
ARI 37, CLE 14
10/17/2021
7 Texans vs
Cardinals
10/24/2021
4:25PM
8 Packers vs
Cardinals
10/28/2021
8:20PM
9 Cardinals vs
49ers
11/07/2021
4:25PM
10 Panthers vs
Cardinals
11/14/2021
4:05PM
11 Cardinals vs
Seahawks
11/21/2021
4:25PM
12Arizona Cardinals ByeN/A
13 Cardinals vs
Bears
12/05/2021
1:00PM
14 Rams vs
Cardinals
12/13/2021
8:15PM
15 Cardinals vs
Lions
12/19/2021
1:00PM
16 Colts vs
Cardinals
12/25/2021
8:15PM
17 Cardinals vs
Cowboys
01/02/2022
1:00PM

Other 2021 Week 5 Matchups

MatchupDate & Time
Rams vs
Seahawks
LAR 26, SEA 17
10/07/2021
Jets vs
Falcons
ATL 27, NYJ 20
10/10/2021
Packers vs
Bengals
GB 25, CIN 22 (OT)
10/10/2021
Lions vs
Vikings
MIN 19, DET 17
10/10/2021
Broncos vs
Steelers
PIT 27, DEN 19
10/10/2021
Dolphins vs
Buccaneers
TB 45, MIA 17
10/10/2021
Saints vs
TBD
NO 33, WSH 22
10/10/2021
Eagles vs
Panthers
PHI 21, CAR 18
10/10/2021
Titans vs
Jaguars
TEN 37, JAX 19
10/10/2021
Patriots vs
Texans
NE 25, HOU 22
10/10/2021
Bears vs
Raiders
CHI 20, LV 9
10/10/2021
Browns vs
Chargers
LAC 47, CLE 42
10/10/2021
Giants vs
Cowboys
DAL 44, NYG 20
10/10/2021
49ers vs
Cardinals
ARI 17, SF 10
10/10/2021
Bills vs
Chiefs
BUF 38, KC 20
10/10/2021
Colts vs
Ravens
BAL 31, IND 25 (OT)
10/11/2021

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