The 49ers will play the Cardinals on Monday, November 21st, 2022. The matchup takes place at Estadio Azteca. Watch this exciting Week 11 matchup at 8:15 pm EST. Check local listings for coverage on ESPN.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props. Read the following to understand point spread betting.
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| Underdog Arizona Cardinals | Favorite San Francisco 49ers |
|---|---|
| Over | Under |
|---|---|
| Underdog Arizona Cardinals | Favorite San Francisco 49ers |
|---|---|
NFL Odds Example
|
Game |
 BetRiversBet |
|---|---|
49ers
Cardinals
11/21/22 8:15pm EST |
Underdog Arizona Cardinals - Arizona Cardinals bettors risk $100 to win $88.5 at -113 odds.
A +10 Arizona Cardinals underdog bet wins if they lose by 9 or fewer, tie, or win outright. The bet pushes if they lose by 10. Your bet loses if they lose by 11 or more.
Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $92.59 at -108 odds.
A -10 San Francisco 49ers favorite bet wins if they win by 11 or more. The bet pushes if they win by 10. Your bet loses if they win by 9 or fewer, tie, or lose outright.
San Francisco 49ers at Arizona Cardinals Prop Bets
| BetRivers Bet |
|
|---|---|
49ers
Cardinals
First Team To Score
11/21/22 8:15pm EST | Bet |
49ers
Cardinals
Tie
First to 15 Points
11/21/22 8:15pm EST | Bet |
49ers
Cardinals
Tie
First to 20 Points
11/21/22 8:15pm EST | Bet |
Colt McCoy
Total Passing Yards
SF at ARI 11/21/22 8:15pm EST | Bet |
| BetRivers | |
Jimmy Garoppolo
Total Passing Yards
SF at ARI 11/21/22 8:15pm EST | Bet |
Jimmy Garoppolo
Total Touchdown Passes
SF at ARI 11/21/22 8:15pm EST | Bet |
Recent Meetings Since 2018
| Week | Game | Result | Margin |
|---|---|---|---|
| 2022 Week 18 | Cardinals vs 49ers Sunday, January 8th, 2023 | SF 38, ARI 13 Levi's Stadium | 49ers by 25 |
| 2022 Week 11 | 49ers vs Cardinals Monday, November 21st, 2022 | SF 38, ARI 10 Estadio Azteca | 49ers by 28 |
| 2021 Week 9 | Cardinals vs 49ers Sunday, November 7th, 2021 | ARI 31, SF 17 Levi's Stadium | Cardinals by 14 |
| 2021 Week 5 | 49ers vs Cardinals Sunday, October 10th, 2021 | ARI 17, SF 10 State Farm Stadium | Cardinals by 7 |
| 2020 Week 16 | 49ers vs Cardinals Saturday, December 26th, 2020 | SF 20, ARI 12 State Farm Stadium | 49ers by 8 |
| 2020 Week 1 | Cardinals vs 49ers Sunday, September 13th, 2020 | ARI 24, SF 20 Levi's Stadium | Cardinals by 4 |
| 2019 Week 11 | Cardinals vs 49ers Sunday, November 17th, 2019 | SF 36, ARI 26 Levi's Stadium | 49ers by 10 |
| 2019 Week 9 | 49ers vs Cardinals Thursday, October 31st, 2019 | SF 28, ARI 25 State Farm Stadium | 49ers by 3 |
| 2018 Week 8 | 49ers vs Cardinals Sunday, October 28th, 2018 | ARI 18, SF 15 State Farm Stadium | Cardinals by 3 |
| 2018 Week 5 | Cardinals vs 49ers Sunday, October 7th, 2018 | ARI 28, SF 18 Levi's Stadium | Cardinals by 10 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xz - San Francisco 49ers | 13 | 4 | 0 | 0.765 | 450 | 277 | 8-1-0 | 5-3-0 | 6-0-0 | 1.000 | 10-2-0 | 0.833 | 10W | 5-0-0 |
| Arizona Cardinals | 4 | 13 | 0 | 0.235 | 340 | 449 | 1-8-0 | 3-5-0 | 1-5-0 | 0.167 | 3-9-0 | 0.250 | 7L | 0-5-0 |
Team Stats
| Stat | San Francisco 49ers | Opponents |
|---|---|---|
| Total 1st Downs | 347 | 291 |
| Total Offensive Yards | 6216 | 5110 |
| Total Rushing Yards | 2360 | 1321 |
| Total Passing Yards | 4049 | 3789 |
| Sacks | 31 | 44 |
| Field Goals | 27 / 32 | 16 / 21 |
| Touchdowns | 52 | 32 |
| Turnover Ratio | 13 |
| Stat | Arizona Cardinals | Opponents |
|---|---|---|
| Total 1st Downs | 326 | 363 |
| Total Offensive Yards | 5499 | 5931 |
| Total Rushing Yards | 1873 | 2016 |
| Total Passing Yards | 3966 | 3915 |
| Sacks | 46 | 36 |
| Field Goals | 26 / 30 | 29 / 31 |
| Touchdowns | 35 | 52 |
| Turnover Ratio | -5 |
Team Season Win Totals
The following are each team's season win totals. Learn more about season win totals.
San Francisco 49ers Season Win Total| BetRivers Bet |
|
|---|---|
49ers
2023 Season Win Total |
| BetRivers Bet |
|
|---|---|
Cardinals
2023 Season Win Total |
Team Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
San Francisco 49ers Futures Odds|
Team | BetRivers |
 BetMGM |
|---|---|---|
| 49ers |
|
Team | BetRivers |
BetMGM |
|---|---|---|
| Cardinals |
2022-23 San Francisco 49ers Games & Results
| Week | Matchup | Date & Time |
|---|---|---|
| Preseason 1 | Packers vs 49ers | SF 28, GB 21 Friday, August 12th, 2022 |
| Preseason 2 | 49ers vs Vikings | SF 17, MIN 7 Saturday, August 20th, 2022 |
| Preseason 3 | 49ers vs Texans | HOU 17, SF 0 Thursday, August 25th, 2022 |
| Week 1 | 49ers vs Bears | CHI 19, SF 10 Sunday, September 11th, 2022 |
| Week 2 | Seahawks vs 49ers | SF 27, SEA 7 Sunday, September 18th, 2022 |
| Week 3 | 49ers vs Broncos | DEN 11, SF 10 Sunday, September 25th, 2022 |
| Week 4 | Rams vs 49ers | SF 24, LAR 9 Monday, October 3rd, 2022 |
| Week 5 | 49ers vs Panthers | SF 37, CAR 15 Sunday, October 9th, 2022 |
| Week 6 | 49ers vs Falcons | ATL 28, SF 14 Sunday, October 16th, 2022 |
| Week 7 | Chiefs vs 49ers | KC 44, SF 23 Sunday, October 23rd, 2022 |
| Week 8 | 49ers vs Rams | SF 31, LAR 14 Sunday, October 30th, 2022 |
| Week 9 | 49ers Bye Week | |
| Week 10 | Chargers vs 49ers | SF 22, LAC 16 Sunday, November 13th, 2022 |
| Week 11 | 49ers vs Cardinals | SF 38, ARI 10 Monday, November 21st, 2022 |
| Week 12 | Saints vs 49ers | SF 13, NO 0 Sunday, November 27th, 2022 |
| Week 13 | Dolphins vs 49ers | SF 33, MIA 17 Sunday, December 4th, 2022 |
| Week 14 | Buccaneers vs 49ers | SF 35, TB 7 Sunday, December 11th, 2022 |
| Week 15 | 49ers vs Seahawks | SF 21, SEA 13 Thursday, December 15th, 2022 |
| Week 16 | Commanders vs 49ers | SF 37, WSH 20 Saturday, December 24th, 2022 |
| Week 17 | 49ers vs Raiders | SF 37, LV 34 (OT) Sunday, January 1st, 2023 |
| Week 18 | Cardinals vs 49ers | SF 38, ARI 13 Sunday, January 8th, 2023 |
| Wild Card | Seahawks vs 49ers NFC Wild Card Playoffs | SF 41, SEA 23 Saturday, January 14th, 2023 |
| Divisional Round | Cowboys vs 49ers NFC Divisional Playoffs | SF 19, DAL 12 Sunday, January 22nd, 2023 |
| Conference Championship | 49ers vs Eagles NFC Championship | PHI 31, SF 7 Sunday, January 29th, 2023 |
2022-23 Arizona Cardinals Games & Results
| Week | Matchup | Date & Time |
|---|---|---|
| Preseason 1 | Cardinals vs Bengals | ARI 36, CIN 23 Friday, August 12th, 2022 |
| Preseason 2 | Ravens vs Cardinals | BAL 24, ARI 17 Sunday, August 21st, 2022 |
| Preseason 3 | Cardinals vs Titans | TEN 26, ARI 23 Saturday, August 27th, 2022 |
| Week 1 | Chiefs vs Cardinals | KC 44, ARI 21 Sunday, September 11th, 2022 |
| Week 2 | Cardinals vs Raiders | ARI 29, LV 23 (OT) Sunday, September 18th, 2022 |
| Week 3 | Rams vs Cardinals | LAR 20, ARI 12 Sunday, September 25th, 2022 |
| Week 4 | Cardinals vs Panthers | ARI 26, CAR 16 Sunday, October 2nd, 2022 |
| Week 5 | Eagles vs Cardinals | PHI 20, ARI 17 Sunday, October 9th, 2022 |
| Week 6 | Cardinals vs Seahawks | SEA 19, ARI 9 Sunday, October 16th, 2022 |
| Week 7 | Saints vs Cardinals | ARI 42, NO 34 Thursday, October 20th, 2022 |
| Week 8 | Cardinals vs Vikings | MIN 34, ARI 26 Sunday, October 30th, 2022 |
| Week 9 | Seahawks vs Cardinals | SEA 31, ARI 21 Sunday, November 6th, 2022 |
| Week 10 | Cardinals vs Rams | ARI 27, LAR 17 Sunday, November 13th, 2022 |
| Week 11 | 49ers vs Cardinals | SF 38, ARI 10 Monday, November 21st, 2022 |
| Week 12 | Chargers vs Cardinals | LAC 25, ARI 24 Sunday, November 27th, 2022 |
| Week 13 | Cardinals Bye Week | |
| Week 14 | Patriots vs Cardinals | NE 27, ARI 13 Monday, December 12th, 2022 |
| Week 15 | Cardinals vs Broncos | DEN 24, ARI 15 Sunday, December 18th, 2022 |
| Week 16 | Buccaneers vs Cardinals | TB 19, ARI 16 (OT) Sunday, December 25th, 2022 |
| Week 17 | Cardinals vs Falcons | ATL 20, ARI 19 Sunday, January 1st, 2023 |
| Week 18 | Cardinals vs 49ers | SF 38, ARI 13 Sunday, January 8th, 2023 |
Other November 21, 2022 NFL Games
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