The 49ers will play the Cardinals on Sunday, November 16th, 2025. The matchup takes place at State Farm Stadium. Watch this exciting Week 11 matchup at 4:05 pm EST. Check local listings for coverage on FOX.

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Key Matchup Stats

Rolling into Week 11, the San Francisco 49ers and Arizona Cardinals will matchup on Sunday, November 16th, 2025 at State Farm Stadium for an important mid-season game. We've compiled some key performance stats below to help you handicap this matchup. Now that the 2025-26 NFL regular season is half over, teams need to sharpen their performance with an eye for the January playoffs.

SportsBetting3.com Power Rankings - As of Week 11 of the 2025-26 season, the San Francisco 49ers have a power ranking of 92.00. Our formula has the Arizona Cardinals at a 89.67 power ranking.
Away San Francisco 49ers - With the season now half over, the San Francisco 49ers have a 4-2-0 record as an away team, ranking them 2nd in the league for away team wins.
Home Arizona Cardinals - The Arizona Cardinals start this Week 11 matchup with a 1-3-0 record as a home team. They rank 6th in the league for home team wins so far in the 2025-26 regular season.
Points Scored - The San Francisco 49ers currently rank 13th (220) looking at Week 11, with the Arizona Cardinals ranked 22nd (202) for points scored to date.
Points Against - The San Francisco 49ers stand 11th (230) now halfway through the regular season for points against. Meanwhile the Arizona Cardinals currently rank 14th (215) for points against.
Team Records - The second half of the season is make or break. Heading into Week 11, the San Francisco 49ers have a 6-4-0 record, with the Arizona Cardinals at 3-6-0 for the 2025-26 regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Avast ye scallywags! The San Francisco 49ers be on a quest to plunder the Arizona Cardinals in a crucial Week 11 clash on Sunday, November 16th, 2025. This be a pivotal moment in the NFL season, with only half of the battles won.

The 49ers be holdin' a 6-4-0 record, while the Cardinals be at 3-6-0. Victory be essential to reach the playoffs come January. The battle be takin' place at State Farm Stadium, in a city rich in culture.

According to the SportsBetting3.com NFL Power Rankings, the 49ers be favored with a rating of 92.00, compared to the Cardinals' 89.67. I recommend betting on this game at BetRivers, or BetMGM. Review this matchup's prop bets below, and look at the odds from our partner sportsbooks. Arrr!

Best 49ers at Cardinals Odds

**Best Point Spread Betting Odds**
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**Best Total Betting Odds**
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**Best Moneyline Betting Odds**
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NFL Odds Example

NFL Odds and Outcomes Explained
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San Francisco 49ers at Arizona Cardinals Prop Bets

NFL Prop Bets
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49ers Cardinals 11/16/25 4:05pm EST	Pending

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 11	49ers vs Cardinals Sunday, November 16th, 2025	SF 41, ARI 22 State Farm Stadium	49ers by 19
2025 Week 3	Cardinals vs 49ers Sunday, September 21st, 2025	SF 16, ARI 15 Levi's Stadium	49ers by 1
2024 Week 18	49ers vs Cardinals Sunday, January 5th, 2025	ARI 47, SF 24 State Farm Stadium	Cardinals by 23
2024 Week 5	Cardinals vs 49ers Sunday, October 6th, 2024	ARI 24, SF 23 Levi's Stadium	Cardinals by 1
2023 Week 15	49ers vs Cardinals Sunday, December 17th, 2023	SF 45, ARI 29 State Farm Stadium	49ers by 16
2023 Week 4	Cardinals vs 49ers Sunday, October 1st, 2023	SF 35, ARI 16 Levi's Stadium	49ers by 19
2022 Week 18	Cardinals vs 49ers Sunday, January 8th, 2023	SF 38, ARI 13 Levi's Stadium	49ers by 25
2022 Week 11	49ers vs Cardinals Monday, November 21st, 2022	SF 38, ARI 10 Estadio Azteca	49ers by 28
2021 Week 9	Cardinals vs 49ers Sunday, November 7th, 2021	ARI 31, SF 17 Levi's Stadium	Cardinals by 14
2021 Week 5	49ers vs Cardinals Sunday, October 10th, 2021	ARI 17, SF 10 State Farm Stadium	Cardinals by 7

Team Standings

2025-2026 NFL Regular Season Standings - San Francisco 49ers, Arizona Cardinals
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xy - San Francisco 49ers	12	5	0	0.706	437	371	5-3-0	7-2-0	4-2-0	0.667	9-3-0	0.750	1L	4-1-0
Arizona Cardinals	3	14	0	0.176	355	488	1-7-0	2-7-0	0-6-0	0.000	3-9-0	0.250	9L	0-5-0

San Francisco 49ers & Arizona Cardinals Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds

No Super Bowl TM San Francisco 49ers YR: futures available

Arizona Cardinals Futures Odds

No Super Bowl TM Arizona Cardinals YR: futures available

San Francisco 49ers & Arizona Cardinals Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco 49ers vs Arizona Cardinals NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, November 16th, 2025 at 4:05 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Arizona Cardinals Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Arizona Cardinals Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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San Francisco 49ers vs Arizona Cardinals Odds

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