San Francisco 49ers vs Arizona Cardinals NFL Betting Lines

Odds Preview 414

The 49ers will play the Cardinals on Sunday, October 10th, 2021. The matchup takes place at State Farm Stadium. Watch this exciting week 5 matchup at 4:25 pm on FOX.

Best Underdog and Favorite Spread Bets

Underdog San Francisco 49ers	Favorite Arizona Cardinals
+5.5 -110 Sb3gen3	-5 -110 Sb3gen2
+5 -105 Sb3gen1	-5 -115 Sb3gen1
+5 -110 Sb3gen2	-5.5 -110 Sb3gen3

SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Sunday. Sb3gen2 has the best favorite Arizona Cardinals spread at -5 points. Sb3gen3 has the best underdog San Francisco 49ers spread at +5.5 points.

Review our point spread betting tutorial and video for more information.

Best Over and Under Total Lines

Over	Under
48o -115 Sb3gen2	48.5u -110 Sb3gen3
48.5o -107 Sb3gen1	48.5u -113 Sb3gen1
48.5o -110 Sb3gen3	48u -105 Sb3gen2

The over under line estimates the combined total of each team's final score. Sb3gen2 has the best over line of 48 points laying $115 to win $100. Sb3gen3 has the best under line of 48.5 u -110.

Best Money Line Bets

Underdog San Francisco 49ers	Favorite Arizona Cardinals
+205 Sb3gen1	-245 Sb3gen1
+205 Sb3gen2	-245 Sb3gen2
+205 Sb3gen3	-255 Sb3gen3

Here are money lines for the outright winner. Favorite Arizona Cardinals has a minus value. Lay $245 at Sb3gen1 to win $100. Underdog San Francisco 49ers has a positive value. Risk $100 at Sb3gen1 to win $205.

San Francisco 49ers vs Arizona Cardinals Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

San Francisco 49ers Super Bowl Odds

Super Bowl 2022 Futures Odds

Outcome	SB3Gen
San Francisco 49ers	+4000

Cached 2021-10-24 16:56:04
Arizona Cardinals Super Bowl Odds

Super Bowl 2022 Futures Odds

Outcome	SB3Gen
Arizona Cardinals	+850

Cached 2021-10-24 16:56:04

Team Stats

2021 San Francisco 49ers Team Stats

Stat	San Francisco 49ers	Opponents
Total 1st Downs	112	104
Total Offensive Yards	1841	1649
Total Rushing Yards	610	566
Total Passing Yards	1231	1083
Sacks	11	9
Field Goals	4 / 6	6 / 9
Touchdowns	15	14
Avg Time Of Possession	30:58	29:01
Turnover Ratio	-5

2021 Arizona Cardinals Team Stats

Stat	Arizona Cardinals	Opponents
Total 1st Downs	137	118
Total Offensive Yards	2418	2057
Total Rushing Yards	784	768
Total Passing Yards	1634	1289
Sacks	17	12
Field Goals	11 / 14	5 / 8
Touchdowns	23	14
Avg Time Of Possession	32:40	27:19
Turnover Ratio	+8

Team Standings

2021 Regular Season Standings

Team	Conf	Div	W	L	T	Pct	Home	Road	Last 5
San Francisco 49ers	2-3-0	0-2-0	2	3	0	0.400	0-2-0	2-1-0	2-3-0
Arizona Cardinals	3-0-0	2-0-0	6	0	0	1.000	2-0-0	4-0-0	5-0-0

2021 San Francisco 49ers Games & Results

Bye Week: 6

Week	Matchup	Date & Time
1	49ers vs Lions	SF 41, DET 33 09/12/2021
2	49ers vs Eagles	SF 17, PHI 11 09/19/2021
3	Packers vs 49ers	GB 30, SF 28 09/26/2021
4	Seahawks vs 49ers	SEA 28, SF 21 10/03/2021
5	49ers vs Cardinals	ARI 17, SF 10 10/10/2021
6	San Francisco 49ers Bye	N/A
7	Colts vs 49ers	10/24/2021 8:20PM
8	49ers vs Bears	10/31/2021 1:00PM
9	Cardinals vs 49ers	11/07/2021 4:25PM
10	Rams vs 49ers	11/15/2021 8:15PM
11	49ers vs Jaguars	11/21/2021 1:00PM
12	Vikings vs 49ers	11/28/2021 4:25PM
13	49ers vs Seahawks	12/05/2021 8:20PM
14	49ers vs Bengals	12/12/2021 1:00PM
15	Falcons vs 49ers	12/19/2021 4:05PM
16	49ers vs Titans	12/23/2021 8:20PM
17	Texans vs 49ers	01/02/2022 4:05PM

2021 Arizona Cardinals Games & Results

Bye Week: 12

Week	Matchup	Date & Time
1	Cardinals vs Titans	ARI 38, TEN 13 09/12/2021
2	Vikings vs Cardinals	ARI 34, MIN 33 09/19/2021
3	Cardinals vs Jaguars	ARI 31, JAX 19 09/26/2021
4	Cardinals vs Rams	ARI 37, LAR 20 10/03/2021
5	49ers vs Cardinals	ARI 17, SF 10 10/10/2021
6	Cardinals vs Browns	ARI 37, CLE 14 10/17/2021
7	Texans vs Cardinals	10/24/2021 4:25PM
8	Packers vs Cardinals	10/28/2021 8:20PM
9	Cardinals vs 49ers	11/07/2021 4:25PM
10	Panthers vs Cardinals	11/14/2021 4:05PM
11	Cardinals vs Seahawks	11/21/2021 4:25PM
12	Arizona Cardinals Bye	N/A
13	Cardinals vs Bears	12/05/2021 1:00PM
14	Rams vs Cardinals	12/13/2021 8:15PM
15	Cardinals vs Lions	12/19/2021 1:00PM
16	Colts vs Cardinals	12/25/2021 8:15PM
17	Cardinals vs Cowboys	01/02/2022 1:00PM

Other 2021 Week 5 Matchups

Matchup	Date & Time
Rams vs Seahawks	LAR 26, SEA 17 10/07/2021
Jets vs Falcons	ATL 27, NYJ 20 10/10/2021
Packers vs Bengals	GB 25, CIN 22 (OT) 10/10/2021
Lions vs Vikings	MIN 19, DET 17 10/10/2021
Broncos vs Steelers	PIT 27, DEN 19 10/10/2021
Dolphins vs Buccaneers	TB 45, MIA 17 10/10/2021
Saints vs TBD	NO 33, WSH 22 10/10/2021
Eagles vs Panthers	PHI 21, CAR 18 10/10/2021
Titans vs Jaguars	TEN 37, JAX 19 10/10/2021
Patriots vs Texans	NE 25, HOU 22 10/10/2021
Bears vs Raiders	CHI 20, LV 9 10/10/2021
Browns vs Chargers	LAC 47, CLE 42 10/10/2021
Giants vs Cowboys	DAL 44, NYG 20 10/10/2021
49ers vs Cardinals	ARI 17, SF 10 10/10/2021
Bills vs Chiefs	BUF 38, KC 20 10/10/2021
Colts vs Ravens	BAL 31, IND 25 (OT) 10/11/2021