San Francisco 49ers vs Arizona Cardinals Odds

The 49ers will play the Cardinals on Sunday, October 10th, 2021. The matchup takes place at State Farm Stadium - Glendale, AZ. Watch this exciting Week 5 matchup at 4:25 pm EDT. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props. Read the following to understand point spread betting.

**Point Spread**
Underdog	Favorite

Point Spread odds are updating, please check back soon.

**Total**
Over	Under

Total odds are updating, please check back soon.

**Moneyline**
Underdog	Favorite

Moneyline odds are updating, please check back soon.

Recent Meetings Since 2017

Week	Game	Result	Margin
2022 Wk 18	Cardinals vs 49ers Sunday, January 8th, 2023	Levi's Stadium - Santa Clara, CA	Tie
2022 Wk 11	49ers vs Cardinals Monday, November 21st, 2022	Estadio Azteca	Tie
2021 Wk 9	Cardinals vs 49ers Sunday, November 7th, 2021	ARI 31, SF 17 Levi's Stadium - Santa Clara, CA	Cardinals by 14
2021 Wk 5	49ers vs Cardinals Sunday, October 10th, 2021	ARI 17, SF 10 State Farm Stadium - Glendale, AZ	Cardinals by 7
2020 Wk 16	49ers vs Cardinals Saturday, December 26th, 2020	SF 20, ARI 12 State Farm Stadium - Glendale, AZ	49ers by 8
2020 Wk 1	Cardinals vs 49ers Sunday, September 13th, 2020	ARI 24, SF 20 Levi's Stadium - Santa Clara, CA	Cardinals by 4
2019 Wk 11	Cardinals vs 49ers Sunday, November 17th, 2019	SF 36, ARI 26 Levi's Stadium - Santa Clara, CA	49ers by 10
2019 Wk 9	49ers vs Cardinals Thursday, October 31st, 2019	SF 28, ARI 25 State Farm Stadium - Glendale, AZ	49ers by 3
2018 Wk 8	49ers vs Cardinals Sunday, October 28th, 2018	ARI 18, SF 15 State Farm Stadium - Glendale, AZ	Cardinals by 3
2018 Wk 5	Cardinals vs 49ers Sunday, October 7th, 2018	ARI 28, SF 18 Levi's Stadium - Santa Clara, CA	Cardinals by 10
2017 Wk 9	Cardinals vs 49ers Sunday, November 5th, 2017	ARI 20, SF 10 Levi's Stadium - Santa Clara, CA	Cardinals by 10
2017 Wk 4	49ers vs Cardinals Sunday, October 1st, 2017	ARI 18, SF 15 (OT) State Farm Stadium - Glendale, AZ	Cardinals by 3

Team Standings

**2021 Standings**
Team	Conf	Div	W	L	T	Pct	Home	Road	Last 5
xy San Francisco 49ers	7-5-0	2-4-0	10	7	0	0.588	4-4-0	6-3-0	4-1-0
xy Arizona Cardinals	7-5-0	4-2-0	11	6	0	0.647	3-5-0	8-1-0	1-4-0

Team Stats

**San Francisco 49ers Team Stats**
Stat	San Francisco 49ers	Opponents
Total 1st Downs	361	318
Total Offensive Yards	6387	5270
Total Rushing Yards	2166	1760
Total Passing Yards	4221	3510
Sacks	48	33
Field Goals	27 / 32	21 / 27
Touchdowns	50	43
Avg Time Of Possession	31:09	29:47
Turnover Ratio	-4

**Arizona Cardinals Team Stats**
Stat	Arizona Cardinals	Opponents
Total 1st Downs	367	336
Total Offensive Yards	6352	5597
Total Rushing Yards	2076	1952
Total Passing Yards	4276	3645
Sacks	41	39
Field Goals	30 / 37	23 / 28
Touchdowns	52	42
Avg Time Of Possession	31:15	28:44
Turnover Ratio	+12

Team Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds

2023 Super Bowl Winner Odds
Team	BetRivers
San Francisco 49ers	+1600 Play

Arizona Cardinals Futures Odds

2023 Super Bowl Winner Odds
Team	BetRivers
Arizona Cardinals	+3500 Play

2021 San Francisco 49ers Games & Results

Week	Matchup	Date & Time
Pre 1	Chiefs vs 49ers Preseason	KC 19, SF 16 Saturday, August 14th, 2021
Pre 2	49ers vs Chargers Preseason	SF 15, LAC 10 Sunday, August 22nd, 2021
Pre 3	Raiders vs 49ers Preseason	SF 34, LV 10 Sunday, August 29th, 2021
1	49ers vs Lions	SF 41, DET 33 Sunday, September 12th, 2021
2	49ers vs Eagles	SF 17, PHI 11 Sunday, September 19th, 2021
3	Packers vs 49ers	GB 30, SF 28 Sunday, September 26th, 2021
4	Seahawks vs 49ers	SEA 28, SF 21 Sunday, October 3rd, 2021
5	49ers vs Cardinals	ARI 17, SF 10 Sunday, October 10th, 2021
7	Colts vs 49ers	IND 30, SF 18 Sunday, October 24th, 2021
8	49ers vs Bears	SF 33, CHI 22 Sunday, October 31st, 2021
9	Cardinals vs 49ers	ARI 31, SF 17 Sunday, November 7th, 2021
10	Rams vs 49ers	SF 31, LAR 10 Monday, November 15th, 2021
11	49ers vs Jaguars	SF 30, JAX 10 Sunday, November 21st, 2021
12	Vikings vs 49ers	SF 34, MIN 26 Sunday, November 28th, 2021
13	49ers vs Seahawks	SEA 30, SF 23 Sunday, December 5th, 2021
14	49ers vs Bengals	SF 26, CIN 23 (OT) Sunday, December 12th, 2021
15	49ers Bye Week
15	Falcons vs 49ers	SF 31, ATL 13 Sunday, December 19th, 2021
16	49ers vs Titans	TEN 20, SF 17 Thursday, December 23rd, 2021
17	Texans vs 49ers	SF 23, HOU 7 Sunday, January 2nd, 2022
18	49ers vs Rams	SF 27, LAR 24 (OT) Sunday, January 9th, 2022
	49ers vs Cowboys NFC Wild Card Playoffs	SF 23, DAL 17 Sunday, January 16th, 2022
	49ers vs Packers NFC Divisional Playoffs	SF 13, GB 10 Saturday, January 22nd, 2022
	49ers vs Rams NFC Championship	LAR 20, SF 17 Sunday, January 30th, 2022

2021 Arizona Cardinals Games & Results

Week	Matchup	Date & Time
Pre 1	Cowboys vs Cardinals Preseason	ARI 19, DAL 16 Friday, August 13th, 2021
Pre 2	Chiefs vs Cardinals Preseason	KC 17, ARI 10 Friday, August 20th, 2021
Pre 3	Cardinals vs Saints Preseason	Canceled Saturday, August 28th, 2021
1	Cardinals vs Titans	ARI 38, TEN 13 Sunday, September 12th, 2021
2	Vikings vs Cardinals	ARI 34, MIN 33 Sunday, September 19th, 2021
3	Cardinals vs Jaguars	ARI 31, JAX 19 Sunday, September 26th, 2021
4	Cardinals vs Rams	ARI 37, LAR 20 Sunday, October 3rd, 2021
5	49ers vs Cardinals	ARI 17, SF 10 Sunday, October 10th, 2021
6	Cardinals vs Browns	ARI 37, CLE 14 Sunday, October 17th, 2021
7	Texans vs Cardinals	ARI 31, HOU 5 Sunday, October 24th, 2021
8	Packers vs Cardinals	GB 24, ARI 21 Thursday, October 28th, 2021
9	Cardinals vs 49ers	ARI 31, SF 17 Sunday, November 7th, 2021
10	Panthers vs Cardinals	CAR 34, ARI 10 Sunday, November 14th, 2021
11	Cardinals vs Seahawks	ARI 23, SEA 13 Sunday, November 21st, 2021
13	Cardinals vs Bears	ARI 33, CHI 22 Sunday, December 5th, 2021
14	Rams vs Cardinals	LAR 30, ARI 23 Monday, December 13th, 2021
15	Cardinals vs Lions	DET 30, ARI 12 Sunday, December 19th, 2021
16	Colts vs Cardinals	IND 22, ARI 16 Saturday, December 25th, 2021
17	Cardinals vs Cowboys	ARI 25, DAL 22 Sunday, January 2nd, 2022
18	Seahawks vs Cardinals	SEA 38, ARI 30 Sunday, January 9th, 2022
	Cardinals vs Rams NFC Wild Card Playoffs	LAR 34, ARI 11 Monday, January 17th, 2022

Current NFL Matchup Lines

Next 10 NFL Matchups
+ Displays more odds
Game	BetRivers Play
Bills Rams 9/08/22 8:20pm EDT	+1 -117 -1 -105
Saints Falcons 9/11/22 1:00pm EDT	-5 -110 +5 -110
Jaguars commanders 9/11/22 1:00pm EDT	+4 -110 -4 -110
Ravens Jets 9/11/22 1:00pm EDT	-5.5 -110 +5.5 -110
Patriots Dolphins 9/11/22 1:00pm EDT	+2.5 -110 -2.5 -112
Colts Texans 9/11/22 1:00pm EDT	-8.5 -105 +8.5 -115
Eagles Lions 9/11/22 1:00pm EDT	-4 -110 +4 -110
Steelers Bengals 9/11/22 1:00pm EDT	+6.5 -110 -6.5 -110
49ers Bears 9/11/22 1:00pm EDT	-6.5 -110 +6.5 -110
Browns Panthers 9/11/22 1:00pm EDT	-2.5 -122 +2.5 +100

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