The 49ers will play the Cardinals on Sunday, November 16th, 2025. The matchup takes place at State Farm Stadium. Watch this exciting Week 11 matchup at 4:05 pm EST. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
Rolling into Week 11, the San Francisco 49ers and Arizona Cardinals will matchup on Sunday, November 16th, 2025 at State Farm Stadium for an important mid-season game. We've compiled some key performance stats below to help you handicap this matchup. Now that the 2025-26 NFL regular season is half over, teams need to sharpen their performance with an eye for the January playoffs.
- SportsBetting3.com Power Rankings - As of Week 11 of the 2025-26 season, the San Francisco 49ers have a power ranking of 92.00. Our formula has the Arizona Cardinals at a 89.67 power ranking.
- Away San Francisco 49ers - With the season now half over, the San Francisco 49ers have a 4-2-0 record as an away team, ranking them 2nd in the league for away team wins.
- Home Arizona Cardinals - The Arizona Cardinals start this Week 11 matchup with a 1-3-0 record as a home team. They rank 6th in the league for home team wins so far in the 2025-26 regular season.
- Points Scored - The San Francisco 49ers currently rank 13th (220) looking at Week 11, with the Arizona Cardinals ranked 22nd (202) for points scored to date.
- Points Against - The San Francisco 49ers stand 11th (230) now halfway through the regular season for points against. Meanwhile the Arizona Cardinals currently rank 14th (215) for points against.
- Team Records - The second half of the season is make or break. Heading into Week 11, the San Francisco 49ers have a 6-4-0 record, with the Arizona Cardinals at 3-6-0 for the 2025-26 regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scallywags! The San Francisco 49ers be on a quest to plunder the Arizona Cardinals in a crucial Week 11 clash on Sunday, November 16th, 2025. This be a pivotal moment in the NFL season, with only half of the battles won.
The 49ers be holdin' a 6-4-0 record, while the Cardinals be at 3-6-0. Victory be essential to reach the playoffs come January. The battle be takin' place at State Farm Stadium, in a city rich in culture.
According to the SportsBetting3.com NFL Power Rankings, the 49ers be favored with a rating of 92.00, compared to the Cardinals' 89.67. I recommend betting on this game at BetRivers, or BetMGM. Review this matchup's prop bets below, and look at the odds from our partner sportsbooks. Arrr!
Best 49ers at Cardinals Odds
| Underdog Arizona Cardinals | Favorite San Francisco 49ers |
|---|---|
| Over | Under |
|---|---|
| Underdog Arizona Cardinals | Favorite San Francisco 49ers |
|---|---|
Matchup Odds FAQs
The San Francisco 49ers are -3.5 -110 point spread favorites at BetMGM, while the Arizona Cardinals are +3.5 -110 point spread underdogs at BetMGM.
The best over line is 48.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 48.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The San Francisco 49ers are the -190 moneyline favorite at BetMGM and the Arizona Cardinals are the +155 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
49ers
Cardinals
11/16/25 4:05pm EST | -3.5 -110+3.5 -110 |
Underdog Arizona Cardinals - Arizona Cardinals bettors risk $100 to win $90.91 at -110 odds.
A +3.5 Arizona Cardinals underdog bet wins if they lose by 3 or fewer, tie, or win outright. Your bet loses if they lose by 4 or more.
Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $90.91 at -110 odds.
A -3.5 San Francisco 49ers favorite bet wins if they win by 4 or more. Your bet loses if they win by 3 or fewer, tie, or lose outright.
San Francisco 49ers at Arizona Cardinals Prop Bets
| BetMGM Bet |
|
|---|---|
49ers
Cardinals
First Team To Score
11/16/25 4:05pm EST | -135+105Bet |
49ers
Cardinals
No Touchdown
To Score 1st Touchdown
11/16/25 4:05pm EST | -150+110+10000Bet |
49ers
Cardinals
Game to Overtime
11/16/25 4:05pm EST | Yes +750No -2500Bet |
49ers
Cardinals
Safety to be Scored
11/16/25 4:05pm EST | Yes +1000No -3000Bet |
| BetMGM | |
Brock Purdy
Interceptions Thrown
SF at ARI 11/16/25 4:05pm EST | 0.5 o -1350.5 u +100Bet |
Jacoby Brissett
Interceptions Thrown
SF at ARI 11/16/25 4:05pm EST | 0.5 o +1100.5 u -145Bet |
Mac Jones
Interceptions Thrown
SF at ARI 11/16/25 4:05pm EST | 0.5 o -1400.5 u +105Bet |
Brock Purdy
Longest Passing Completion
SF at ARI 11/16/25 4:05pm EST | 35.5 o -11035.5 u -120Bet |
| BetMGM | |
Jacoby Brissett
Longest Passing Completion
SF at ARI 11/16/25 4:05pm EST | 33.5 o -12033.5 u -110Bet |
Mac Jones
Longest Passing Completion
SF at ARI 11/16/25 4:05pm EST | 34.5 o -11034.5 u -118Bet |
Chad Ryland
Total Kicking Points
SF at ARI 11/16/25 4:05pm EST | 6.5 o +1006.5 u -130Bet |
Eddy Pineiro
Total Kicking Points
SF at ARI 11/16/25 4:05pm EST | 7.5 o +1057.5 u -145Bet |
| BetMGM | |
Brock Purdy
Total Pass Completions
SF at ARI 11/16/25 4:05pm EST | 22.5 o +10022.5 u -135Bet |
Jacoby Brissett
Total Pass Completions
SF at ARI 11/16/25 4:05pm EST | 22.5 o -10522.5 u -125Bet |
Brock Purdy
Total Passing Yards
SF at ARI 11/16/25 4:05pm EST | 253.5 o -115253.5 u -115Bet |
Jacoby Brissett
Total Passing Yards
SF at ARI 11/16/25 4:05pm EST | 229.5 o -115229.5 u -115Bet |
| BetMGM | |
Mac Jones
Total Passing Yards
SF at ARI 11/16/25 4:05pm EST | 243.5 o -115243.5 u -115Bet |
Brock Purdy
Total Touchdown Passes
SF at ARI 11/16/25 4:05pm EST | 1.5 o -1551.5 u +115Bet |
Jacoby Brissett
Total Touchdown Passes
SF at ARI 11/16/25 4:05pm EST | 1.5 o -1051.5 u -125Bet |
Mac Jones
Total Touchdown Passes
SF at ARI 11/16/25 4:05pm EST | 1.5 o -1101.5 u -118Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 11 | 49ers vs Cardinals Sunday, November 16th, 2025 | SF 41, ARI 22 State Farm Stadium | 49ers by 19 |
| 2025 Week 3 | Cardinals vs 49ers Sunday, September 21st, 2025 | SF 16, ARI 15 Levi's Stadium | 49ers by 1 |
| 2024 Week 18 | 49ers vs Cardinals Sunday, January 5th, 2025 | ARI 47, SF 24 State Farm Stadium | Cardinals by 23 |
| 2024 Week 5 | Cardinals vs 49ers Sunday, October 6th, 2024 | ARI 24, SF 23 Levi's Stadium | Cardinals by 1 |
| 2023 Week 15 | 49ers vs Cardinals Sunday, December 17th, 2023 | SF 45, ARI 29 State Farm Stadium | 49ers by 16 |
| 2023 Week 4 | Cardinals vs 49ers Sunday, October 1st, 2023 | SF 35, ARI 16 Levi's Stadium | 49ers by 19 |
| 2022 Week 18 | Cardinals vs 49ers Sunday, January 8th, 2023 | SF 38, ARI 13 Levi's Stadium | 49ers by 25 |
| 2022 Week 11 | 49ers vs Cardinals Monday, November 21st, 2022 | SF 38, ARI 10 Estadio Azteca | 49ers by 28 |
| 2021 Week 9 | Cardinals vs 49ers Sunday, November 7th, 2021 | ARI 31, SF 17 Levi's Stadium | Cardinals by 14 |
| 2021 Week 5 | 49ers vs Cardinals Sunday, October 10th, 2021 | ARI 17, SF 10 State Farm Stadium | Cardinals by 7 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| San Francisco 49ers | 10 | 4 | 0 | 0.714 | 344 | 293 | 4-2-0 | 6-2-0 | 4-1-0 | 0.800 | 8-2-0 | 0.800 | 4W | 4-1-0 |
| Arizona Cardinals | 3 | 11 | 0 | 0.214 | 302 | 388 | 1-6-0 | 2-5-0 | 0-5-0 | 0.000 | 3-7-0 | 0.300 | 6L | 0-5-0 |
San Francisco 49ers & Arizona Cardinals Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
San Francisco 49ers Futures Odds|
Team | BetMGM |
|---|---|
| 49ers | +2000 Bet |
No Super Bowl TM Arizona Cardinals YR: futures available
San Francisco 49ers & Arizona Cardinals Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco 49ers vs Arizona Cardinals NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, November 16th, 2025 at 4:05 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Arizona Cardinals Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Arizona Cardinals Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
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