The Cardinals will play the Colts on Sunday, October 12th, 2025. The matchup takes place at Lucas Oil Stadium. Watch this exciting Week 6 matchup at 1:00 pm EDT. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The Arizona Cardinals and Indianapolis Colts will take the field at Lucas Oil Stadium for a key Week 6 matchup on Sunday, October 12th, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.
- SportsBetting3.com Power Rankings - Heading into Week 6 of the 2025-26 season, the Arizona Cardinals have a power ranking of 92.67. Our calculations have the Indianapolis Colts at a 99.33 power ranking.
- Away Arizona Cardinals - Now in the middle of the season, the Arizona Cardinals have a 1-1-0 record as an away team, ranking them 3rd in the league for away team wins.
- Home Indianapolis Colts - The Indianapolis Colts come to this Week 6 matchup with a 3-0-0 record as a home team. They rank 1st in the league for home team wins so far this season.
- Points Scored - The Arizona Cardinals currently rank 17th (103) on the edge of Week 6, with the Indianapolis Colts ranked 2nd (163) for points scored to date.
- Points Against - The Arizona Cardinals stand 22nd (96) in the middle weeks of the regular season for points against. As for the Indianapolis Colts, they currently rank 23rd (89) for points against.
- Team Records - Standings become more important now more than ever. Approaching Week 6, the Arizona Cardinals have a 2-3-0 record, with the Indianapolis Colts at 4-1-0 for the 2025-26 regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scallywags! The Arizona Cardinals be takin' on the Indianapolis Colts this Sunday!
The Cardinals be sittin' at a 2-3-0 record, while the Colts be boastin' a 4-1-0 record.
This crucial mid-season clash be happenin' at the Lucas Oil Stadium in Indianapolis.
Bet this game at BetMGM or our preferred sports betting partner BetRivers. Look at this game's prop bets and compare odds from partner sports betting sites. May the best team win!
Best Cardinals at Colts Odds
| Underdog Arizona Cardinals | Favorite Indianapolis Colts |
|---|---|
| Over | Under |
|---|---|
| Underdog Arizona Cardinals | Favorite Indianapolis Colts |
|---|---|
Matchup Odds FAQs
The Indianapolis Colts are -8.5 -110 point spread favorites at BetMGM, while the Arizona Cardinals are +8.5 -110 point spread underdogs at BetMGM.
The best over line is 46.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 46.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The Indianapolis Colts are the -500 moneyline favorite at BetMGM and the Arizona Cardinals are the +375 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
Cardinals
Colts
10/12/25 1:00pm EDT | +8.5 -110-8.5 -110 |
Underdog Arizona Cardinals - Arizona Cardinals bettors risk $100 to win $90.91 at -110 odds.
A +8.5 Arizona Cardinals underdog bet wins if they lose by 8 or fewer, tie, or win outright. Your bet loses if they lose by 9 or more.
Favorite Indianapolis Colts - Indianapolis Colts bettors risk $100 to win $90.91 at -110 odds.
A -8.5 Indianapolis Colts favorite bet wins if they win by 9 or more. Your bet loses if they win by 8 or fewer, tie, or lose outright.
Arizona Cardinals at Indianapolis Colts Prop Bets
| BetMGM Bet |
|
|---|---|
Cardinals
Colts
First Team To Score
10/12/25 1:00pm EDT | +154-200Bet |
Cardinals
Colts
No Touchdown
To Score 1st Touchdown
10/12/25 1:00pm EDT | +185-250+15000Bet |
Cardinals
Colts
Game to Overtime
10/12/25 1:00pm EDT | Yes +875No -5000Bet |
Cardinals
Colts
Safety to be Scored
10/12/25 1:00pm EDT | Yes +1000No -3000Bet |
| BetMGM | |
Daniel Jones
Interceptions Thrown
ARI at IND 10/12/25 1:00pm EDT | 0.5 o +1050.5 u -145Bet |
Kyler Murray
Interceptions Thrown
ARI at IND 10/12/25 1:00pm EDT | 0.5 o -1050.5 u -125Bet |
Daniel Jones
Longest Passing Completion
ARI at IND 10/12/25 1:00pm EDT | 34.5 o -12034.5 u -110Bet |
Kyler Murray
Longest Passing Completion
ARI at IND 10/12/25 1:00pm EDT | 33.5 o -12033.5 u -110Bet |
| BetMGM | |
Chad Ryland
Total Kicking Points
ARI at IND 10/12/25 1:00pm EDT | 5.5 o -1405.5 u +105Bet |
Michael Badgley
Total Kicking Points
ARI at IND 10/12/25 1:00pm EDT | 7.5 o -1257.5 u -105Bet |
Daniel Jones
Total Pass Completions
ARI at IND 10/12/25 1:00pm EDT | 21.5 o -10521.5 u -125Bet |
Kyler Murray
Total Pass Completions
ARI at IND 10/12/25 1:00pm EDT | 22.5 o +10022.5 u -135Bet |
| BetMGM | |
Daniel Jones
Total Passing Yards
ARI at IND 10/12/25 1:00pm EDT | 232.5 o -115232.5 u -115Bet |
Kyler Murray
Total Passing Yards
ARI at IND 10/12/25 1:00pm EDT | 217.5 o -115217.5 u -115Bet |
Daniel Jones
Total Touchdown Passes
ARI at IND 10/12/25 1:00pm EDT | 1.5 o -1101.5 u -120Bet |
Kyler Murray
Total Touchdown Passes
ARI at IND 10/12/25 1:00pm EDT | 1.5 o +1401.5 u -190Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 6 | Cardinals vs Colts Sunday, October 12th, 2025 | IND 31, ARI 27 Lucas Oil Stadium | Colts by 4 |
| 2024 Preseason Week 2 | Cardinals vs Colts Saturday, August 17th, 2024 | IND 21, ARI 13 Lucas Oil Stadium | Colts by 8 |
| 2021 Week 16 | Colts vs Cardinals Saturday, December 25th, 2021 | IND 22, ARI 16 State Farm Stadium | Colts by 6 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Indianapolis Colts | 5 | 1 | 0 | 0.833 | 194 | 116 | 4-0-0 | 1-1-0 | 1-0-0 | 1.000 | 4-0-0 | 1.000 | 2W | 4-1-0 |
| Arizona Cardinals | 2 | 4 | 0 | 0.333 | 130 | 127 | 1-2-0 | 1-2-0 | 0-2-0 | 0.000 | 2-2-0 | 0.500 | 4L | 1-4-0 |
Arizona Cardinals & Indianapolis Colts Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Arizona Cardinals Futures Odds|
Team | BetMGM |
|---|---|
| Cardinals | +25000 Bet |
|
Team | BetMGM |
|---|---|
| Colts | +1700 Bet |
Arizona Cardinals & Indianapolis Colts Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Arizona Cardinals vs Indianapolis Colts NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, October 12th, 2025 at 1:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Arizona Cardinals vs Indianapolis Colts Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Arizona Cardinals vs Indianapolis Colts Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other October 12, 2025 NFL Games
- Denver Broncos vs New York Jets - 10/12/25 9:30am EDT
- New England Patriots vs New Orleans Saints - 10/12/25 1:00pm EDT
- Los Angeles Chargers vs Miami Dolphins - 10/12/25 1:00pm EDT
- Seattle Seahawks vs Jacksonville Jaguars - 10/12/25 1:00pm EDT
- Los Angeles Rams vs Baltimore Ravens - 10/12/25 1:00pm EDT
- Cleveland Browns vs Pittsburgh Steelers - 10/12/25 1:00pm EDT
- Dallas Cowboys vs Carolina Panthers - 10/12/25 1:03pm EDT
- Tennessee Titans vs Las Vegas Raiders - 10/12/25 4:05pm EDT
- Cincinnati Bengals vs Green Bay Packers - 10/12/25 4:25pm EDT
- San Francisco 49ers vs Tampa Bay Buccaneers - 10/12/25 4:25pm EDT
- Detroit Lions vs Kansas City Chiefs - 10/12/25 8:20pm EDT