The Cardinals will play the Colts on Sunday, October 12th, 2025. The matchup takes place at Lucas Oil Stadium. Watch this exciting Week 6 matchup at 1:00 pm EDT. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

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Matchup Stats
Captain Shady Lines
Best Odds
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Prop Bets
Recent Meetings
Team Standings
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Key Matchup Stats

The Arizona Cardinals and Indianapolis Colts will take the field at Lucas Oil Stadium for a key Week 6 matchup on Sunday, October 12th, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.

SportsBetting3.com Power Rankings - Heading into Week 6 of the 2025-26 season, the Arizona Cardinals have a power ranking of 92.67. Our calculations have the Indianapolis Colts at a 99.33 power ranking.
Away Arizona Cardinals - Now in the middle of the season, the Arizona Cardinals have a 1-1-0 record as an away team, ranking them 3rd in the league for away team wins.
Home Indianapolis Colts - The Indianapolis Colts come to this Week 6 matchup with a 3-0-0 record as a home team. They rank 1st in the league for home team wins so far this season.
Points Scored - The Arizona Cardinals currently rank 17th (103) on the edge of Week 6, with the Indianapolis Colts ranked 2nd (163) for points scored to date.
Points Against - The Arizona Cardinals stand 22nd (96) in the middle weeks of the regular season for points against. As for the Indianapolis Colts, they currently rank 23rd (89) for points against.
Team Records - Standings become more important now more than ever. Approaching Week 6, the Arizona Cardinals have a 2-3-0 record, with the Indianapolis Colts at 4-1-0 for the 2025-26 regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Avast ye scallywags! The Arizona Cardinals be takin' on the Indianapolis Colts this Sunday!

The Cardinals be sittin' at a 2-3-0 record, while the Colts be boastin' a 4-1-0 record.

This crucial mid-season clash be happenin' at the Lucas Oil Stadium in Indianapolis.

Bet this game at BetMGM or our preferred sports betting partner BetRivers. Look at this game's prop bets and compare odds from partner sports betting sites. May the best team win!

Best Cardinals at Colts Odds

**Best Point Spread Betting Odds**
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**Best Total Betting Odds**
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**Best Moneyline Betting Odds**
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NFL Odds Example

NFL Odds and Outcomes Explained
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Arizona Cardinals at Indianapolis Colts Prop Bets

NFL Prop Bets
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	Bet
Cardinals Colts 10/12/25 1:00pm EDT	Pending

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 6	Cardinals vs Colts Sunday, October 12th, 2025	IND 31, ARI 27 Lucas Oil Stadium	Colts by 4
2024 Preseason Week 2	Cardinals vs Colts Saturday, August 17th, 2024	IND 21, ARI 13 Lucas Oil Stadium	Colts by 8
2021 Week 16	Colts vs Cardinals Saturday, December 25th, 2021	IND 22, ARI 16 State Farm Stadium	Colts by 6

Team Standings

2025-2026 NFL Regular Season Standings - Arizona Cardinals, Indianapolis Colts
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
Indianapolis Colts	8	9	0	0.471	466	412	6-3-0	2-6-0	2-4-0	0.333	6-6-0	0.500	7L	0-5-0
Arizona Cardinals	3	14	0	0.176	355	488	1-7-0	2-7-0	0-6-0	0.000	3-9-0	0.250	9L	0-5-0

Arizona Cardinals & Indianapolis Colts Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Arizona Cardinals Futures Odds

No Super Bowl TM Arizona Cardinals YR: futures available

Indianapolis Colts Futures Odds

No Super Bowl TM Indianapolis Colts YR: futures available

Arizona Cardinals & Indianapolis Colts Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Arizona Cardinals vs Indianapolis Colts NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, October 12th, 2025 at 1:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the Arizona Cardinals vs Indianapolis Colts Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Arizona Cardinals vs Indianapolis Colts Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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