The Patriots will play the Bills on Sunday, October 5th, 2025. The matchup takes place at Highmark Stadium. Watch this exciting Week 5 matchup at 8:22 pm EDT. Check local listings for coverage on NBC.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The New England Patriots and Buffalo Bills will take the field at Highmark Stadium for a key Week 5 matchup on Sunday, October 5th, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.
- SportsBetting3.com Power Rankings - Heading into Week 5 of the 2025-26 season, the New England Patriots have a power ranking of 96.00. Our calculations have the Buffalo Bills at a 99.33 power ranking.
- Away New England Patriots - Now in the middle of the season, the New England Patriots have a 1-0-0 record as an away team, ranking them 2nd in the league for away team wins.
- Home Buffalo Bills - The Buffalo Bills come to this Week 5 matchup with a 3-0-0 record as a home team. They rank 1st in the league for home team wins so far this season.
- Points Scored - The New England Patriots currently rank 10th (102) on the edge of Week 5, with the Buffalo Bills ranked 2nd (133) for points scored to date.
- Points Against - The New England Patriots stand 19th (81) in the middle weeks of the regular season for points against. As for the Buffalo Bills, they currently rank 14th (90) for points against.
- Team Records - Standings become more important now more than ever. Approaching Week 5, the New England Patriots have a 2-2-0 record, with the Buffalo Bills at 4-0-0 for the 2025-26 regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye mateys! The New England Patriots be facing the Buffalo Bills on Sunday!
The Patriots be standin' at 2-2-0, while the Bills be a perfect 4-0-0.
This crucial mid-season clash be happenin' at the famous Highmark Stadium in Buffalo.
The Bills be holdin' a higher rank in the Power Rankings at 99.33 compared to the Patriots' 96.00. Ye can bet this game at BetMGM or our preferred sports betting partner BetRivers. Look at this game's prop bets and compare odds from partner sports betting sites. Arrr, may the best team prevail on the gridiron!
Best Patriots at Bills Odds
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NFL Odds Example
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New England Patriots at Buffalo Bills Prop Bets
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Patriots
Bills
10/05/25 8:22pm EDT | Pending |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 15 | Bills vs Patriots Sunday, December 14th, 2025 | BUF 35, NE 31 Gillette Stadium | Bills by 4 |
| 2025 Week 5 | Patriots vs Bills Sunday, October 5th, 2025 | NE 23, BUF 20 Highmark Stadium | Patriots by 3 |
| 2024 Week 18 | Bills vs Patriots Sunday, January 5th, 2025 | NE 23, BUF 16 Gillette Stadium | Patriots by 7 |
| 2024 Week 16 | Patriots vs Bills Sunday, December 22nd, 2024 | BUF 24, NE 21 Highmark Stadium | Bills by 3 |
| 2023 Week 17 | Patriots vs Bills Sunday, December 31st, 2023 | BUF 27, NE 21 Highmark Stadium | Bills by 6 |
| 2023 Week 7 | Bills vs Patriots Sunday, October 22nd, 2023 | NE 29, BUF 25 Gillette Stadium | Patriots by 4 |
| 2022 Week 18 | Patriots vs Bills Sunday, January 8th, 2023 | BUF 35, NE 23 Highmark Stadium | Bills by 12 |
| 2022 Week 13 | Bills vs Patriots Thursday, December 1st, 2022 | BUF 24, NE 10 Gillette Stadium | Bills by 14 |
| 2021 Wild Card | Patriots vs Bills Saturday, January 15th, 2022 AFC Wild Card Playoffs | BUF 47, NE 17 Highmark Stadium | Bills by 30 |
| 2021 Week 16 | Bills vs Patriots Sunday, December 26th, 2021 | BUF 33, NE 21 Gillette Stadium | Bills by 12 |
| 2021 Week 13 | Patriots vs Bills Monday, December 6th, 2021 | NE 14, BUF 10 Highmark Stadium | Patriots by 4 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
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| xz - New England Patriots | 14 | 3 | 0 | 0.824 | 490 | 320 | 6-3-0 | 8-0-0 | 5-1-0 | 0.833 | 9-3-0 | 0.750 | 3W | 4-1-0 |
| xy - Buffalo Bills | 12 | 5 | 0 | 0.706 | 481 | 365 | 7-2-0 | 5-3-0 | 4-2-0 | 0.667 | 9-3-0 | 0.750 | 1W | 4-1-0 |
New England Patriots & Buffalo Bills Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
New England Patriots Futures OddsNo Super Bowl TM New England Patriots YR: futures available
Buffalo Bills Futures OddsNo Super Bowl TM Buffalo Bills YR: futures available
New England Patriots & Buffalo Bills Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the New England Patriots vs Buffalo Bills NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, October 5th, 2025 at 8:22 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the New England Patriots vs Buffalo Bills Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the New England Patriots vs Buffalo Bills Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other October 5, 2025 NFL Games
- Minnesota Vikings vs Cleveland Browns
- New York Giants vs New Orleans Saints
- Houston Texans vs Baltimore Ravens
- Denver Broncos vs Philadelphia Eagles
- Dallas Cowboys vs New York Jets
- Las Vegas Raiders vs Indianapolis Colts
- Miami Dolphins vs Carolina Panthers
- Tampa Bay Buccaneers vs Seattle Seahawks
- Tennessee Titans vs Arizona Cardinals
- Detroit Lions vs Cincinnati Bengals
- Washington Commanders vs Los Angeles Chargers