The Broncos will play the 49ers on Sunday, October 4th, 2026. The matchup takes place at Levi's Stadium. Watch this exciting Week 4 matchup at 4:25 pm EDT. Check local listings for coverage on CBS.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The Denver Broncos and San Francisco 49ers will take the field at Levi's Stadium for a key Week 4 matchup on Sunday, October 4th, 2026. Have a look at each team's key performance stats below as they continue to make their way through the 2026-27 NFL regular season.
- SportsBetting3.com Power Rankings - Heading into Week 4 of the 2026-27 season, the Denver Broncos have a power ranking of 94.00. Our calculations have the San Francisco 49ers at a 100.00 power ranking.
- Away Denver Broncos - Now in the middle of the season, the Denver Broncos have a 0-1-0 record as an away team, ranking them 3rd in the league for away team wins.
- Home San Francisco 49ers - The San Francisco 49ers come to this Week 4 matchup with a 2-0-0 record as a home team. They rank 1st in the league for home team wins so far this season.
- Points Scored - The Denver Broncos currently rank 17th (60) on the edge of Week 4, with the San Francisco 49ers ranked 2nd (98) for points scored to date.
- Points Against - The Denver Broncos stand 13th (70) in the middle weeks of the regular season for points against. As for the San Francisco 49ers, they currently rank 22nd (50) for points against.
- Team Records - Standings become more important now more than ever. Approaching Week 4, the Denver Broncos have a 2-1-0 record, with the San Francisco 49ers at 3-0-0 for the 2026-27 regular season.
Best Broncos at 49ers Odds
| Underdog Denver Broncos | Favorite San Francisco 49ers |
|---|---|
| Over | Under |
|---|
| Underdog Denver Broncos | Favorite San Francisco 49ers |
|---|---|
Matchup Odds FAQs
The San Francisco 49ers are -3 -108 point spread favorites at BetRivers, while the Denver Broncos are +3 -113 point spread underdogs at BetRivers.
The San Francisco 49ers are the -152 moneyline favorite at BetRivers and the Denver Broncos are the +125 moneyline underdog at BetRivers.
NFL Odds Example
|
Game |
 BetRiversBet |
|---|---|
Broncos
49ers
10/04/26 4:25pm EDT | +3 -113-3 -108 |
Underdog Denver Broncos - Denver Broncos bettors risk $100 to win $88.5 at -113 odds.
A +3 Denver Broncos underdog bet wins if they lose by 2 or fewer, tie, or win outright. The bet pushes if they lose by 3. Your bet loses if they lose by 4 or more.
Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $92.59 at -108 odds.
A -3 San Francisco 49ers favorite bet wins if they win by 4 or more. The bet pushes if they win by 3. Your bet loses if they win by 2 or fewer, tie, or lose outright.
Denver Broncos at San Francisco 49ers Prop Bets
| BetRivers Bet |
|
|---|---|
Broncos
49ers
10/04/26 4:25pm EDT | Pending BetRivers |
Recent Meetings Since 2022
| Week | Game | Result | Margin |
|---|---|---|---|
| 2026 Week 4 | Broncos vs 49ers Sunday, October 4th, 2026 | SF 24, DEN 14 Levi's Stadium | 49ers by 10 |
| 2025 Preseason Week 1 | Broncos vs 49ers Saturday, August 9th, 2025 | DEN 30, SF 9 Levi's Stadium | Broncos by 21 |
| 2023 Preseason Week 2 | Broncos vs 49ers Saturday, August 19th, 2023 | SF 21, DEN 20 Levi's Stadium | 49ers by 1 |
| 2022 Week 3 | 49ers vs Broncos Sunday, September 25th, 2022 | DEN 11, SF 10 Empower Field at Mile High | Broncos by 1 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| San Francisco 49ers | 5 | 0 | 0 | 1.000 | 154 | 93 | 3-0-0 | 2-0-0 | 3-0-0 | 1.000 | 3-0-0 | 1.000 | 5W | 5-0-0 |
| Denver Broncos | 3 | 2 | 0 | 0.600 | 97 | 111 | 2-0-0 | 1-2-0 | 1-1-0 | 0.500 | 2-1-0 | 0.667 | 1W | 3-2-0 |
Denver Broncos & San Francisco 49ers Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Denver Broncos Futures Odds|
Team | BetRivers |
|---|---|
| Broncos | +2200 Bet |
|
Team | BetRivers |
|---|---|
| 49ers | +800 Bet |
Denver Broncos & San Francisco 49ers Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Denver Broncos vs San Francisco 49ers NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, October 4th, 2026 at 4:25 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Denver Broncos vs San Francisco 49ers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Denver Broncos vs San Francisco 49ers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other October 4, 2026 NFL Games
- Indianapolis Colts vs Washington Commanders - 10/04/26 9:30am EDT
- Los Angeles Rams vs Philadelphia Eagles - 10/04/26 1:00pm EDT
- Arizona Cardinals vs New York Giants - 10/04/26 1:00pm EDT
- Dallas Cowboys vs Houston Texans - 10/04/26 1:00pm EDT
- New York Jets vs Chicago Bears - 10/04/26 1:00pm EDT
- New England Patriots vs Buffalo Bills - 10/04/26 1:00pm EDT
- Jacksonville Jaguars vs Cincinnati Bengals - 10/04/26 1:02pm EDT
- Green Bay Packers vs Tampa Bay Buccaneers - 10/04/26 1:02pm EDT
- Tennessee Titans vs Baltimore Ravens - 10/04/26 1:02pm EDT
- Miami Dolphins vs Minnesota Vikings - 10/04/26 4:05pm EDT
- Los Angeles Chargers vs Seattle Seahawks - 10/04/26 4:25pm EDT
- Kansas City Chiefs vs Las Vegas Raiders - 10/04/26 4:25pm EDT
- Detroit Lions vs Carolina Panthers - 10/04/26 8:20pm EDT