The Cardinals will play the Marlins on Wednesday, April 22nd, 2026. Your timezone's first pitch time is 12:10 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - The St. Louis Cardinals have a 93.00 power ranking. The power ranking for the Miami Marlins is 91.67.
- Visiting St. Louis Cardinals - The St. Louis Cardinals have a 7-4 record as a visiting team, ranking them 3rd Overall for visiting team wins.
- Home Miami Marlins - The Miami Marlins have a 9-6 record as a home team. They rank 1st for home team wins in the Overall standings.
- Runs Scored - The St. Louis Cardinals currently stand 9th (111) Overall, with the Miami Marlins ranking 11th (108) for runs scored.
- Runs Allowed - The St. Louis Cardinals are 5th (119) Overall for runs allowed. The Miami Marlins stand 11th (109) for runs allowed.
- Team Streaks - The St. Louis Cardinals won their last game. Meanwhile, the Miami Marlins lost their last game.
- Team Records - The St. Louis Cardinals have a 14-9 Overall record (1.5 GB National Central Division), with the Miami Marlins possessing a 11-13 Overall standing (5.0 GB National East Division).
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye, scallywags! The Cardinals be ready to plunder the Marlins on Wednesday... (Arrr!) Their 14-9 record be no match for the Marlins' measly 11-13 overall... (Shiver me timbers!) With a win percentage of 0.609, the Cardinals be the clear favorite.
The Marlins be sinkin' faster than a ship in a storm... (Avast!) With a win percentage of only 0.458, they be doomed to Davy Jones' locker. The Cardinals be comin' in hot, with a 6-4 record in their last 10... (Arrr, bet on this game at SportsBetting3.com and review the odds below!)
So hoist the Jolly Roger and set sail for victory, me hearties! The Marlins be no match for the mighty Cardinals. (Avast, bet on this game and plunder yer winnings at SportsBetting3.com!) May the wind be at the Cardinals' backs as they sail to another victory on the high seas.
Best Cardinals at Marlins Odds
| Underdog St. Louis Cardinals | Favorite Miami Marlins |
|---|---|
| Over | Under |
|---|---|
| Underdog St. Louis Cardinals | Favorite Miami Marlins |
|---|---|
Matchup Odds FAQs
The Miami Marlins are the -145 moneyline favorite at BetMGM and the St. Louis Cardinals are the +118 moneyline underdog at BetMGM.
The best over line is 8.5 -105 runs at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 8.5 -115 runs at BetMGM, and that means you risk $115 to win $100 betting the under.
The Miami Marlins are -1.5 +140 run line favorites at BetMGM, while the St. Louis Cardinals are +1.5 -170 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Cardinals
Marlins
4/22/26 12:10pm EDT | +118-145 |
- St. Louis Cardinals bettors risk $100 to win $118 at +118 odds. The implied probability for St. Louis Cardinals is 45.87%.
- Miami Marlins bettors risk $100 to win $68.97 at -145 odds. The implied probability for Miami Marlins is 59.18%.
St. Louis Cardinals at Miami Marlins Prop Bets
| BetMGM Bet |
|
|---|---|
Cardinals
Marlins
First Team to Score
4/22/26 12:10pm EDT | -140+110Bet |
Cardinals
Marlins
Tie
1st Inning Winner
4/22/26 12:10pm EDT | +310+270-130Bet |
Cardinals
Marlins
Tie
First 3 Innings Winner
4/22/26 12:10pm EDT | +160+120+300Bet |
Cardinals
Marlins
To Extra Innings
4/22/26 12:10pm EDT | Yes +750No -1200Bet |
| BetMGM | |
Cardinals
Marlins
1st Team to Score Will Win
4/22/26 12:10pm EDT | Yes -250No +190Bet |
Marlins
Total Runs
STL at MIA 4/22/26 12:10pm EDT | 4.5 o -1024.5 u -130Bet |
Cardinals
Total Runs
STL at MIA 4/22/26 12:10pm EDT | 3.5 o -1303.5 u -102Bet |
St. Louis Cardinals & Miami Marlins Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
St. Louis Cardinals World Series Odds|
Team | BetMGM |
|---|---|
| Cardinals | +15000 Bet |
|
Team | BetMGM |
|---|---|
| Marlins | +20000 Bet |
St. Louis Cardinals & Miami Marlins Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| St. Louis Cardinals | 14 | 9 | 0.609 | +2.0 | 7-5 | 7-4 | 111 | 119 | -8 | W1 | 6-4 |
| Miami Marlins | 11 | 13 | 0.458 | +5.5 | 9-6 | 2-7 | 108 | 109 | -1 | L1 | 3-7 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the St. Louis Cardinals vs Miami Marlins MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, April 22nd, 2026 at 12:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the St. Louis Cardinals vs Miami Marlins Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the St. Louis Cardinals vs Miami Marlins Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other April 22, 2026 MLB Games
- Cincinnati Reds vs Tampa Bay Rays - 4/22/26 1:10pm EDT
- Houston Astros vs Cleveland Guardians - 4/22/26 1:11pm EDT
- Baltimore Orioles vs Kansas City Royals - 4/22/26 2:10pm EDT
- Toronto Blue Jays vs Los Angeles Angels - 4/22/26 3:07pm EDT
- Oakland Athletics vs Seattle Mariners - 4/22/26 4:10pm EDT
- Milwaukee Brewers vs Detroit Tigers - 4/22/26 6:40pm EDT
- New York Yankees vs Boston Red Sox - 4/22/26 6:45pm EDT
- Atlanta Braves vs Washington Nationals - 4/22/26 6:45pm EDT
- Minnesota Twins vs New York Mets - 4/22/26 7:10pm EDT
- Philadelphia Phillies vs Chicago Cubs - 4/22/26 7:40pm EDT
- Pittsburgh Pirates vs Texas Rangers - 4/22/26 8:08pm EDT
- San Diego Padres vs Colorado Rockies - 4/22/26 8:40pm EDT
- Chicago White Sox vs Arizona Diamondbacks - 4/22/26 9:40pm EDT
- Los Angeles Dodgers vs San Francisco Giants - 4/22/26 9:45pm EDT