Chicago Cubs vs Pittsburgh Pirates Odds

The Cubs will play the Pirates on Wednesday, September 17th, 2025. Your timezone's first pitch time is 12:35 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

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Best Cubs at Pirates Odds

**Best Moneyline Betting Odds**
Underdog Pittsburgh Pirates	Favorite Chicago Cubs
+115 BetMGM Bet	-140 BetMGM Bet

The Chicago Cubs are the -140 moneyline favorite. Risk $140 to win $100 on the Chicago Cubs at BetMGM. The Pittsburgh Pirates are the +115 underdog at BetMGM. Risk $100 to win $115 on the Pittsburgh Pirates. Learn more about how to bet on money lines.

**Best Total Betting Odds**
Over	Under
8 o -102 BetMGM Bet	8 u -118 BetMGM Bet

BetMGM has the best over line of 8 runs. Risk $102 to win $100. BetMGM has the best under line of 8 runs. Risk $118 to win $100. Our tutorial explains more about total bets.

**Best Run Line Betting Odds**
Underdog Pittsburgh Pirates	Favorite Chicago Cubs
+1.5 -150 BetMGM Bet	-1.5 +125 BetMGM Bet

The Chicago Cubs have a -1.5 +125 run line at BetMGM OH. They are the run line favorite in this matchup. The Pittsburgh Pirates have a +1.5 -150 run line at BetMGM OH. The Pittsburgh Pirates are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the Chicago Cubs vs Pittsburgh Pirates MLB game on Wednesday, September 17th, 2025?

The Chicago Cubs are the -140 moneyline favorite at BetMGM and the Pittsburgh Pirates are the +115 moneyline underdog at BetMGM.

What is the over-under total line for the Chicago Cubs vs Pittsburgh Pirates MLB game on Wednesday, September 17th, 2025?

The best over line is 8 -102 runs at BetMGM, which means you risk $102 to win $100 betting the over. The best under line is 8 -118 runs at BetMGM, and that means you risk $118 to win $100 betting the under.

What is the run line for the Chicago Cubs vs Pittsburgh Pirates MLB game on Wednesday, September 17th, 2025?

The Chicago Cubs are -1.5 +125 run line favorites at BetMGM, while the Pittsburgh Pirates are +1.5 -150 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained
Game	BetMGM Bet
Cubs Pirates 9/17/25 12:35pm EDT	-140 +115

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Possible Moneyline Outcomes

Pittsburgh Pirates bettors risk $100 to win $115 at +115 odds. The implied probability for Pittsburgh Pirates is 46.51%.
Chicago Cubs bettors risk $100 to win $71.43 at -140 odds. The implied probability for Chicago Cubs is 58.33%.

Chicago Cubs at Pittsburgh Pirates Prop Bets

MLB Prop Bets
+ Displays more odds
	BetMGM Bet
Cubs Pirates First Team to Score 9/17/25 12:35pm EDT	-175 +135 Bet
Cubs Pirates Tie 1st Inning Winner 9/17/25 12:35pm EDT	+270 +340 -140 Bet
Cubs Pirates Tie First 3 Innings Winner 9/17/25 12:35pm EDT	+125 +165 +275 Bet
Cubs Pirates To Extra Innings 9/17/25 12:35pm EDT	Yes +725 No -1200 Bet
	BetMGM
Cubs Pirates 1st Team to Score Will Win 9/17/25 12:35pm EDT	Yes -250 No +190 Bet
Cubs Total Runs CUB at PIT 9/17/25 12:35pm EDT	4.5 o +110 4.5 u -145 Bet
Pirates Total Runs CUB at PIT 9/17/25 12:35pm EDT	3.5 o -105 3.5 u -125 Bet
Johan Oviedo Strikeouts Thrown CUB at PIT 9/17/25 12:35pm EDT	4.5 o +105 4.5 u -140 Bet
	BetMGM
Matthew Boyd Strikeouts Thrown CUB at PIT 9/17/25 12:35pm EDT	5.5 o +115 5.5 u -150 Bet

Chicago Cubs & Pittsburgh Pirates Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Chicago Cubs World Series Odds

No World Series TM Chicago Cubs YR: futures available

Pittsburgh Pirates World Series Odds

No World Series TM Pittsburgh Pirates YR: futures available

Chicago Cubs & Pittsburgh Pirates Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - Chicago Cubs, Pittsburgh Pirates
Team	W	L	Pct	GB	Home	Away	RS	RA	Diff	Strk	L10
y - Chicago Cubs	92	70	0.568	+5.0	50-31	42-39	793	649	+144	W3	4-6
e - Pittsburgh Pirates	71	91	0.438	+26.0	44-37	27-54	583	645	-62	L1	6-4

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Chicago Cubs vs Pittsburgh Pirates MLB Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, September 17th, 2025 at 12:35 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's MLB page, look for the Chicago Cubs vs Pittsburgh Pirates Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Chicago Cubs vs Pittsburgh Pirates Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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