St. Louis Cardinals vs Chicago Cubs Odds

The Cardinals will play the Cubs on Sunday, September 28th, 2025. Your timezone's first pitch time is 3:20 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

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Best Cardinals at Cubs Odds

**Best Moneyline Betting Odds**
Underdog St. Louis Cardinals	Favorite Chicago Cubs
+125 BetMGM Bet	-150 BetMGM Bet

The Chicago Cubs are the -150 moneyline favorite. Risk $150 to win $100 on the Chicago Cubs at BetMGM. The St. Louis Cardinals are the +125 underdog at BetMGM. Risk $100 to win $125 on the St. Louis Cardinals. Learn more about how to bet on money lines.

**Best Total Betting Odds**
Over	Under
7 o -118 BetMGM Bet	7 u -102 BetMGM Bet

BetMGM has the best over line of 7 runs. Risk $118 to win $100. BetMGM has the best under line of 7 runs. Risk $102 to win $100. Our tutorial explains more about total bets.

**Best Run Line Betting Odds**
Underdog St. Louis Cardinals	Favorite Chicago Cubs
+1.5 -190 BetMGM Bet	-1.5 +155 BetMGM Bet

The Chicago Cubs have a -1.5 +155 run line at BetMGM OH. They are the run line favorite in this matchup. The St. Louis Cardinals have a +1.5 -190 run line at BetMGM OH. The St. Louis Cardinals are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the St. Louis Cardinals vs Chicago Cubs MLB game on Sunday, September 28th, 2025?

The Chicago Cubs are the -150 moneyline favorite at BetMGM and the St. Louis Cardinals are the +125 moneyline underdog at BetMGM.

What is the over-under total line for the St. Louis Cardinals vs Chicago Cubs MLB game on Sunday, September 28th, 2025?

The best over line is 7 -118 runs at BetMGM, which means you risk $118 to win $100 betting the over. The best under line is 7 -102 runs at BetMGM, and that means you risk $102 to win $100 betting the under.

What is the run line for the St. Louis Cardinals vs Chicago Cubs MLB game on Sunday, September 28th, 2025?

The Chicago Cubs are -1.5 +155 run line favorites at BetMGM, while the St. Louis Cardinals are +1.5 -190 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained
Game	BetMGM Bet
Cardinals Cubs 9/28/25 3:20pm EDT	+125 -150

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Possible Moneyline Outcomes

St. Louis Cardinals bettors risk $100 to win $125 at +125 odds. The implied probability for St. Louis Cardinals is 44.44%.
Chicago Cubs bettors risk $100 to win $66.67 at -150 odds. The implied probability for Chicago Cubs is 60%.

St. Louis Cardinals at Chicago Cubs Prop Bets

MLB Prop Bets
+ Displays more odds
	BetMGM Bet
Cardinals Cubs First Team to Score 9/28/25 3:20pm EDT	-125 +100 Bet
Cardinals Cubs Tie 1st Inning Winner 9/28/25 3:20pm EDT	+375 +310 -165 Bet
Cardinals Cubs Tie First 3 Innings Winner 9/28/25 3:20pm EDT	+180 +130 +240 Bet
Cardinals Cubs To Extra Innings 9/28/25 3:20pm EDT	Yes +725 No -1200 Bet
	BetMGM
Cardinals Cubs 1st Team to Score Will Win 9/28/25 3:20pm EDT	Yes -250 No +190 Bet
Cubs Total Runs STL at CUB 9/28/25 3:20pm EDT	3.5 o -125 3.5 u -102 Bet
Cardinals Total Runs STL at CUB 9/28/25 3:20pm EDT	3.5 o +110 3.5 u -145 Bet
Javier Assad Strikeouts Thrown STL at CUB 9/28/25 3:20pm EDT	3.5 o -165 3.5 u +125 Bet

St. Louis Cardinals & Chicago Cubs Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

St. Louis Cardinals World Series Odds

No World Series TM St. Louis Cardinals YR: futures available

Chicago Cubs World Series Odds

No World Series TM Chicago Cubs YR: futures available

St. Louis Cardinals & Chicago Cubs Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - St. Louis Cardinals, Chicago Cubs
Team	W	L	Pct	GB	Home	Away	RS	RA	Diff	Strk	L10
y - Chicago Cubs	92	70	0.568	+5.0	50-31	42-39	793	649	+144	W3	4-6
e - St. Louis Cardinals	78	84	0.481	+19.0	44-37	34-47	689	754	-65	L4	4-6

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the St. Louis Cardinals vs Chicago Cubs MLB Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 28th, 2025 at 3:20 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's MLB page, look for the St. Louis Cardinals vs Chicago Cubs Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the St. Louis Cardinals vs Chicago Cubs Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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