Buffalo Bills vs New England Patriots Odds

The Bills will play the Patriots on Sunday, December 14th, 2025. The matchup takes place at Gillette Stadium. Watch this exciting Week 15 matchup at 1:00 pm EST. Check local listings for coverage on CBS.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.


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Table of Contents

Key Matchup Stats

It's now Week 15, as the 2025-26 NFL regular season is coming to a close. This week's action includes a matchup between the Buffalo Bills and New England Patriots. They'll play on Sunday, December 14th, 2025 at Gillette Stadium, in a game that may affect this season's playoff picture. We've highlighted each team's key performance stats below. Take note of the following as you handicap this matchup.

  • SportsBetting3.com Power Rankings - Now Week 15 of the 2025-26 NFL regular season, the Buffalo Bills have a 96.00 power ranking based on our formula. Their opponent, the New England Patriots, currently possess a 99.33 power ranking.
  • Away Buffalo Bills - With the season coming to a close, the Buffalo Bills have a 3-3-0 record as an away team, ranking them 4th in the league for away team wins.
  • Home New England Patriots - The New England Patriots come to this Week 15 game with a 5-2-0 record as a home team. They rank 2nd in the league for home team wins as the 2025-26 regular season wraps up.
  • Points Scored - The Buffalo Bills currently rank 5th (376) headed into Week 15, with the New England Patriots ranked 6th (351) for points scored to date.
  • Points Against - As the regular season winds down, the Buffalo Bills rank 19th (293) for points score against them. Note that the New England Patriots now rank 27th (241) for points scored against.
  • Team Records - The final games of the season will determine who heads to the playoffs. Heading into Week 15, the Buffalo Bills have a 9-4-0 record, with the New England Patriots at 11-2-0 for the 2025-26 NFL regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast ye scurvy dogs! The Bills be sailin' to enemy territory in Foxborough.

The regular season be nearin' its end, and this match may shape the playoff picture.

Buffalo stand at 9-4-0, while New England be boastin' an 11-2-0 record.

An epic clash awaits at Gillette Stadium. Will the Bills plunder or be plundered?

The SportsBetting3.com Power Rankings show the Patriots holdin' the edge over the Bills.

If ye be brave enough, place a bet at BetRivers or BetMGM. Arrr!

Be sure to look at this matchup's prop bets below, me hearties.

We've compared odds from our partner sportsbooks, so prepare for battle on Sunday!

Best Bills at Patriots Odds


Best Point Spread Betting Odds
Underdog

New England Patriots
Favorite

Buffalo Bills
The Buffalo Bills have a -1 -105 point spread at BetMGM OH. They are the point spread favorite in this matchup. The New England Patriots have a +1 -115 point spread at BetMGM OH. The New England Patriots are the point spread underdogs. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 49.5 points. Risk $110 to win $100. BetMGM has the best under line of 49.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

New England Patriots
Favorite

Buffalo Bills
The Buffalo Bills are the -115 moneyline favorite. Risk $115 to win $100 on the Buffalo Bills at BetMGM. The New England Patriots are the -105 underdog at BetMGM. Risk $105 to win $100 on the New England Patriots. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Buffalo Bills vs New England Patriots NFL game on Sunday, December 14th, 2025?

The Buffalo Bills are -1 -105 point spread favorites at BetMGM, while the New England Patriots are +1 -115 point spread underdogs at BetMGM.

What is the over-under total line for the Buffalo Bills vs New England Patriots NFL game on Sunday, December 14th, 2025?

The best over line is 49.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 49.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Buffalo Bills vs New England Patriots NFL game on Sunday, December 14th, 2025?

The Buffalo Bills are the -115 moneyline favorite at BetMGM and the New England Patriots are the -105 moneyline underdog at BetMGM.

NFL Odds Example

NFL Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Bills
Patriots
12/14/25 1:00pm EST
-1 -105+1 -115
Bet $100 at BetMGM Ohio
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Underdog New England Patriots - New England Patriots bettors risk $100 to win $86.96 at -115 odds.

A +1 New England Patriots underdog bet wins if the result is a tie, or they win outright. The bet pushes if they lose by 1. Your bet loses if they lose by 2 or more.

Favorite Buffalo Bills - Buffalo Bills bettors risk $100 to win $95.24 at -105 odds.

A -1 Buffalo Bills favorite bet wins if they win by 2 or more. The bet pushes if they win by 1. Your bet loses if the result is a tie, or they lose outright.

Buffalo Bills at New England Patriots Prop Bets

NFL Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Bills
Patriots
First Team To Score
12/14/25 1:00pm EST
-110-115Bet
Bills
Patriots
No Touchdown
To Score 1st Touchdown
12/14/25 1:00pm EST
-115-115+10000Bet
Bills
Patriots
Game to Overtime
12/14/25 1:00pm EST
Yes +725No -2500Bet
Bills
Patriots
Safety to be Scored
12/14/25 1:00pm EST
Yes +1000No -3000Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
WeekGameResultMargin
2025
Week 5
Patriots vs Bills
Sunday, October 5th, 2025
NE 23, BUF 20
Highmark Stadium
Patriots by 3
2024
Week 18
Bills vs Patriots
Sunday, January 5th, 2025
NE 23, BUF 16
Gillette Stadium
Patriots by 7
2024
Week 16
Patriots vs Bills
Sunday, December 22nd, 2024
BUF 24, NE 21
Highmark Stadium
Bills by 3
2023
Week 17
Patriots vs Bills
Sunday, December 31st, 2023
BUF 27, NE 21
Highmark Stadium
Bills by 6
2023
Week 7
Bills vs Patriots
Sunday, October 22nd, 2023
NE 29, BUF 25
Gillette Stadium
Patriots by 4
2022
Week 18
Patriots vs Bills
Sunday, January 8th, 2023
BUF 35, NE 23
Highmark Stadium
Bills by 12
2022
Week 13
Bills vs Patriots
Thursday, December 1st, 2022
BUF 24, NE 10
Gillette Stadium
Bills by 14
2021
Wild Card
Patriots vs Bills
Saturday, January 15th, 2022
AFC Wild Card Playoffs
BUF 47, NE 17
Highmark Stadium
Bills by 30
2021
Week 16
Bills vs Patriots
Sunday, December 26th, 2021
BUF 33, NE 21
Gillette Stadium
Bills by 12
2021
Week 13
Patriots vs Bills
Monday, December 6th, 2021
NE 14, BUF 10
Highmark Stadium
Patriots by 4

Team Standings

2025-2026 NFL Regular Season Standings - Buffalo Bills, New England Patriots
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
New England Patriots11200.8463512415-2-06-0-03-0-01.0006-2-00.75010W5-0-0
Buffalo Bills9400.6923762936-1-03-3-02-2-00.5006-3-00.6672W3-2-0

Buffalo Bills & New England Patriots Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Buffalo Bills Futures Odds
2025-26 Buffalo Bills Super Bowl Odds

Team
BetMGM Sports Betting BetMGM
Bills
+850
Bet
New England Patriots Futures Odds
2025-26 New England Patriots Super Bowl Odds

Team
BetMGM Sports Betting BetMGM
Patriots
+1000
Bet

Buffalo Bills & New England Patriots Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Buffalo Bills vs New England Patriots NFL Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Sunday, December 14th, 2025 at 1:00 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's NFL page, look for the Buffalo Bills vs New England Patriots Game.

    Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Buffalo Bills vs New England Patriots Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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