The Mariners will play the White Sox on Wednesday, May 21st, 2025. Your timezone's first pitch time is 2:10 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
| Bonus | |
|---|---|
 #1 BetMGMREVIEW | New Customers - Up to $1500 Paid Back in Bonus Bets Bonus Bets Expire in 7 Days One new customer offer/Add'l Terms Bet Now 21+ Playable in Ohio only Gambling Problem? Call 1-800-589-9966 |
Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - The Seattle Mariners have a 95.00 power ranking. The power ranking for the Chicago White Sox is 83.67.
- Visiting Seattle Mariners - The Seattle Mariners have a 14-8 record as a visiting team, ranking them 1st Overall for visiting team wins.
- Home Chicago White Sox - The Chicago White Sox have a 9-13 record as a home team. They rank 8th for home team wins in the Overall standings.
- Runs Scored - The Seattle Mariners currently stand 10th (221) Overall, with the Chicago White Sox ranking 25th (158) for runs scored.
- Runs Allowed - The Seattle Mariners are 17th (194) Overall for runs allowed. The Chicago White Sox stand 10th (215) for runs allowed.
- Team Streaks - The Seattle Mariners have won their last 4 games. Meanwhile, the Chicago White Sox have lost their last 5 games.
- Team Records - The Seattle Mariners have a 27-19 Overall record (0.0 GB American West Division), with the Chicago White Sox possessing a 14-34 Overall standing (17.0 GB American Central Division).
Captain Shady Lines
A broken compass is right at least twice a day.
Arr, ye scurvy dogs! The Mariners face the White Sox in Chicago...
The Mariners be sailin' in with a strong record, ready to plunder...
But don't be fooled by the White Sox's poor record, they be cunning...
SportsBetting3.com be where ye can bet on this game, review the odds below...
Ye better be prepared for a fierce battle on the diamond, mateys...
Will the Mariners continue their winning streak, or will the White Sox surprise?
Make yer bets wisely, for the outcome of this game be uncertain...
Sail on, Mariners, and may the wind be at yer backs on Wednesday!
Best Mariners at White Sox Odds
| Underdog Chicago White Sox | Favorite Seattle Mariners |
|---|---|
| Over | Under |
|---|---|
| Underdog Chicago White Sox | Favorite Seattle Mariners |
|---|---|
Matchup Odds FAQs
The Seattle Mariners are the -150 moneyline favorite at BetMGM and the Chicago White Sox are the +125 moneyline underdog at BetMGM.
The best over line is 8.5 -110 runs at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 8.5 -110 runs at BetMGM, and that means you risk $110 to win $100 betting the under.
The Seattle Mariners are -1.5 +110 run line favorites at BetMGM, while the Chicago White Sox are +1.5 -130 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Mariners
White Sox
5/21/25 2:10pm EDT | -150+125 |
- Chicago White Sox bettors risk $100 to win $125 at +125 odds. The implied probability for Chicago White Sox is 44.44%.
- Seattle Mariners bettors risk $100 to win $66.67 at -150 odds. The implied probability for Seattle Mariners is 60%.
Seattle Mariners at Chicago White Sox Prop Bets
| BetMGM Bet |
|
|---|---|
Mariners
White Sox
First Team to Score
5/21/25 2:10pm EDT | -175+135Bet |
Mariners
White Sox
Tie
1st Inning Winner
5/21/25 2:10pm EDT | +270+310-130Bet |
Mariners
White Sox
Tie
First 3 Innings Winner
5/21/25 2:10pm EDT | +125+150+300Bet |
Mariners
White Sox
To Extra Innings
5/21/25 2:10pm EDT | Yes +750No -1200Bet |
| BetMGM | |
Mariners
White Sox
1st Team to Score Will Win
5/21/25 2:10pm EDT | Yes -250No +190Bet |
Mariners
Total Runs
SEA at CWS 5/21/25 2:10pm EDT | 4.5 o -1104.5 u -115Bet |
Logan Evans
Strikeouts Thrown
SEA at CWS 5/21/25 2:10pm EDT | 3.5 o -1103.5 u -120Bet |
Shane Smith
Strikeouts Thrown
SEA at CWS 5/21/25 2:10pm EDT | 4.5 o -1654.5 u +125Bet |
Seattle Mariners & Chicago White Sox Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Seattle Mariners World Series Odds|
Team | BetMGM |
|---|---|
| Mariners | +3000 Bet |
|
Team | BetMGM |
|---|---|
| White Sox | +200000 Bet |
Seattle Mariners & Chicago White Sox Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Seattle Mariners | 29 | 23 | 0.558 | +5.0 | 13-11 | 16-12 | 238 | 219 | +19 | L2 | 6-4 |
| Chicago White Sox | 17 | 37 | 0.315 | +18.0 | 12-15 | 5-22 | 183 | 234 | -51 | L2 | 3-7 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Seattle Mariners vs Chicago White Sox MLB Game
-
Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, May 21st, 2025 at 2:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
-
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
-
Tap to the sportsbook's MLB page, look for the Seattle Mariners vs Chicago White Sox Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Seattle Mariners vs Chicago White Sox Game.
-
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other May 21, 2025 MLB Games
- Cincinnati Reds vs Pittsburgh Pirates
- Baltimore Orioles vs Milwaukee Brewers
- Chicago Cubs vs Miami Marlins
- Houston Astros vs Tampa Bay Rays
- Detroit Tigers vs St. Louis Cardinals
- Cleveland Guardians vs Minnesota Twins
- Kansas City Royals vs San Francisco Giants
- New York Mets vs Boston Red Sox
- Atlanta Braves vs Washington Nationals
- Texas Rangers vs New York Yankees
- San Diego Padres vs Toronto Blue Jays
- Cleveland Guardians vs Minnesota Twins
- Philadelphia Phillies vs Colorado Rockies
- Los Angeles Angels vs Oakland Athletics
- Arizona Diamondbacks vs Los Angeles Dodgers