The Astros will play the Mariners on Tuesday, September 22nd, 2026. Your timezone's first pitch time is 9:40 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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 #1 BetRiversREVIEW | New Customers - 2nd Chance Bet up to $500 - Code: SPORTS Bet Now 21+ Playable in PA only Gambling Problem? Call 1-800-GAMBLER |
Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best Astros at Mariners Odds
| Underdog Houston Astros | Favorite Seattle Mariners |
|---|---|
| Over | Under |
|---|---|
| Underdog Houston Astros | Favorite Seattle Mariners |
|---|---|
Matchup Odds FAQs
The Seattle Mariners are the -141 moneyline favorite at BetRivers and the Houston Astros are the +118 moneyline underdog at BetRivers.
The best over line is 7.5 -121 runs at BetRivers, which means you risk $121 to win $100 betting the over. The best under line is 7.5 -103 runs at BetRivers, and that means you risk $103 to win $100 betting the under.
The Seattle Mariners are -1 +100 run line favorites at BetRivers, while the Houston Astros are +1 -122 run line underdogs at BetRivers.
MLB Odds Example
|
Game |
 BetRiversBet |
|---|---|
Astros
Mariners
9/22/26 9:40pm EDT | +118-141 |
- Houston Astros bettors risk $100 to win $118 at +118 odds. The implied probability for Houston Astros is 45.87%.
- Seattle Mariners bettors risk $100 to win $70.92 at -141 odds. The implied probability for Seattle Mariners is 58.51%.
Houston Astros at Seattle Mariners Prop Bets
| BetRivers Bet |
|
|---|---|
Astros
Mariners
9/22/26 9:40pm EDT | Pending BetRivers |
Houston Astros & Seattle Mariners Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Houston Astros World Series OddsNo World Series TM Houston Astros YR: futures available
Seattle Mariners World Series OddsNo World Series TM Seattle Mariners YR: futures available
Houston Astros & Seattle Mariners Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| x - Houston Astros | 81 | 81 | 0.500 | +22.0 | 39-42 | 42-39 | 734 | 766 | -32 | W2 | 5-5 |
| e - Seattle Mariners | 76 | 86 | 0.469 | +27.0 | 43-38 | 33-48 | 664 | 722 | -58 | W2 | 6-4 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Houston Astros vs Seattle Mariners MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Tuesday, September 22nd, 2026 at 9:40 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Houston Astros vs Seattle Mariners Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Houston Astros vs Seattle Mariners Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 22, 2026 MLB Games
- Toronto Blue Jays vs Baltimore Orioles - 9/22/26 6:35pm EDT
- Washington Nationals vs Detroit Tigers - 9/22/26 6:40pm EDT
- Milwaukee Brewers vs Philadelphia Phillies - 9/22/26 6:40pm EDT
- St. Louis Cardinals vs Pittsburgh Pirates - 9/22/26 6:40pm EDT
- Cleveland Guardians vs Boston Red Sox - 9/22/26 6:45pm EDT
- Tampa Bay Rays vs New York Yankees - 9/22/26 7:05pm EDT
- Cincinnati Reds vs Atlanta Braves - 9/22/26 7:15pm EDT
- Chicago White Sox vs Kansas City Royals - 9/22/26 7:40pm EDT
- New York Mets vs Texas Rangers - 9/22/26 8:13pm EDT
- Arizona Diamondbacks vs Colorado Rockies - 9/22/26 8:40pm EDT
- Los Angeles Angels vs Oakland Athletics - 9/22/26 9:40pm EDT