The Astros will play the Rays on Wednesday, May 21st, 2025. Your timezone's first pitch time is 1:10 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - The Houston Astros have a 92.67 power ranking. The power ranking for the Tampa Bay Rays is 87.67.
- Visiting Houston Astros - The Houston Astros have a 10-13 record as a visiting team, ranking them 5th Overall for visiting team wins.
- Home Tampa Bay Rays - The Tampa Bay Rays have a 11-18 record as a home team. They rank 6th for home team wins in the Overall standings.
- Runs Scored - The Houston Astros currently stand 18th (189) Overall, with the Tampa Bay Rays ranking 20th (182) for runs scored.
- Runs Allowed - The Houston Astros are 25th (168) Overall for runs allowed. The Tampa Bay Rays stand 18th (192) for runs allowed.
- Team Streaks - The Houston Astros have won their last 2 games. Meanwhile, the Tampa Bay Rays have lost their last 2 games.
- Team Records - The Houston Astros have a 25-22 Overall record (2.5 GB American West Division), with the Tampa Bay Rays possessing a 21-26 Overall standing (6.5 GB American East Division).
Captain Shady Lines
A broken compass is right at least twice a day.
Avast, ye scurvy dogs! The Astros be ready to plunder Tampa Bay...
With a record like ours, the Rays won't stand a chance at home...
But don't take me word for it, head to SportsBetting3.com, bet on this game...
And review the odds below, because the Astros be on a winning streak!
Best Astros at Rays Odds
| Underdog Tampa Bay Rays | Favorite Houston Astros |
|---|---|
| Over | Under |
|---|---|
| Underdog Tampa Bay Rays | Favorite Houston Astros |
|---|---|
Matchup Odds FAQs
The Houston Astros are the -150 moneyline favorite at BetMGM and the Tampa Bay Rays are the +148 moneyline underdog at BetRivers.
The best over line is 8.5 -118 runs at BetMGM, which means you risk $118 to win $100 betting the over. The best under line is 9 -130 runs at BetRivers, and that means you risk $130 to win $100 betting the under.
The Houston Astros are -1.5 +115 run line favorites at BetMGM, while the Tampa Bay Rays are +1.5 -115 run line underdogs at BetRivers.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Astros
Rays
5/21/25 1:10pm EDT | -150+125 |
- Tampa Bay Rays bettors risk $100 to win $125 at +125 odds. The implied probability for Tampa Bay Rays is 44.44%.
- Houston Astros bettors risk $100 to win $66.67 at -150 odds. The implied probability for Houston Astros is 60%.
Houston Astros at Tampa Bay Rays Prop Bets
| BetMGM Bet |
|
|---|---|
Astros
Rays
First Team to Score
5/21/25 1:10pm EDT | -200+155Bet |
Astros
Rays
Tie
1st Inning Winner
5/21/25 1:10pm EDT | +250+375-140Bet |
Astros
Rays
Tie
First 3 Innings Winner
5/21/25 1:10pm EDT | +110+185+280Bet |
Astros
Rays
To Extra Innings
5/21/25 1:10pm EDT | Yes +775No -1400Bet |
| BetMGM | |
Astros
Rays
1st Team to Score Will Win
5/21/25 1:10pm EDT | Yes -250No +190Bet |
Astros
Total Runs
HOU at TAM 5/21/25 1:10pm EDT | 4.5 o -1184.5 u -110Bet |
Rays
Total Runs
HOU at TAM 5/21/25 1:10pm EDT | 3.5 o -1253.5 u -105Bet |
Hunter Brown
Strikeouts Thrown
HOU at TAM 5/21/25 1:10pm EDT | 6.5 o -1506.5 u +115Bet |
| BetMGM | |
Taj Bradley
Strikeouts Thrown
HOU at TAM 5/21/25 1:10pm EDT | 5.5 o +1405.5 u -190Bet |
Houston Astros & Tampa Bay Rays Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Houston Astros World Series Odds|
Team | BetMGM |
 BetRivers |
|---|---|---|
| Astros | +2500 Bet | +2500 Bet |
|
Team | BetMGM |
BetRivers |
|---|---|---|
| Rays | +8000 Bet | +7500 Bet |
Houston Astros & Tampa Bay Rays Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Houston Astros | 27 | 25 | 0.519 | +6.5 | 17-10 | 10-15 | 209 | 187 | +22 | W1 | 5-5 |
| Tampa Bay Rays | 25 | 26 | 0.490 | +8.0 | 15-18 | 10-8 | 199 | 200 | -1 | W4 | 6-4 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Houston Astros vs Tampa Bay Rays MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, May 21st, 2025 at 1:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Houston Astros vs Tampa Bay Rays Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Houston Astros vs Tampa Bay Rays Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other May 21, 2025 MLB Games
- Cincinnati Reds vs Pittsburgh Pirates - 5/21/25 12:35pm EDT
- Baltimore Orioles vs Milwaukee Brewers - 5/21/25 1:10pm EDT
- Chicago Cubs vs Miami Marlins - 5/21/25 1:10pm EDT
- Detroit Tigers vs St. Louis Cardinals - 5/21/25 1:15pm EDT
- Seattle Mariners vs Chicago White Sox - 5/21/25 2:10pm EDT
- Cleveland Guardians vs Minnesota Twins - 5/21/25 3:30pm EDT
- Kansas City Royals vs San Francisco Giants - 5/21/25 3:45pm EDT
- New York Mets vs Boston Red Sox - 5/21/25 6:45pm EDT
- Atlanta Braves vs Washington Nationals - 5/21/25 6:45pm EDT
- Texas Rangers vs New York Yankees - 5/21/25 7:05pm EDT
- San Diego Padres vs Toronto Blue Jays - 5/21/25 7:07pm EDT
- Cleveland Guardians vs Minnesota Twins - 5/21/25 7:10pm EDT
- Philadelphia Phillies vs Colorado Rockies - 5/21/25 8:40pm EDT
- Los Angeles Angels vs Oakland Athletics - 5/21/25 10:05pm EDT
- Arizona Diamondbacks vs Los Angeles Dodgers - 5/21/25 10:10pm EDT