Houston Astros vs Tampa Bay Rays Odds

The Astros will play the Rays on Wednesday, May 21st, 2025. Your timezone's first pitch time is 1:10 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - The Houston Astros have a 92.67 power ranking. The power ranking for the Tampa Bay Rays is 87.67.
  • Visiting Houston Astros - The Houston Astros have a 10-13 record as a visiting team, ranking them 5th Overall for visiting team wins.
  • Home Tampa Bay Rays - The Tampa Bay Rays have a 11-18 record as a home team. They rank 6th for home team wins in the Overall standings.
  • Runs Scored - The Houston Astros currently stand 18th (189) Overall, with the Tampa Bay Rays ranking 20th (182) for runs scored.
  • Runs Allowed - The Houston Astros are 25th (168) Overall for runs allowed. The Tampa Bay Rays stand 18th (192) for runs allowed.
  • Team Streaks - The Houston Astros have won their last 2 games. Meanwhile, the Tampa Bay Rays have lost their last 2 games.
  • Team Records - The Houston Astros have a 25-22 Overall record (2.5 GB American West Division), with the Tampa Bay Rays possessing a 21-26 Overall standing (6.5 GB American East Division).

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast, ye scurvy dogs! The Astros be ready to plunder Tampa Bay...

With a record like ours, the Rays won't stand a chance at home...

But don't take me word for it, head to SportsBetting3.com, bet on this game...

And review the odds below, because the Astros be on a winning streak!

Best Astros at Rays Odds


Best Moneyline Betting Odds
Underdog

Tampa Bay Rays
Favorite

Houston Astros
The Houston Astros are the -150 moneyline favorite. Risk $150 to win $100 on the Houston Astros at BetMGM. The Tampa Bay Rays are the +148 underdog at BetRivers. Risk $100 to win $148 on the Tampa Bay Rays. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 8.5 runs. Risk $118 to win $100. BetRivers has the best under line of 9 runs. Risk $130 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

Tampa Bay Rays
Favorite

Houston Astros
The Houston Astros have a -1.5 +115 run line at BetMGM PA. They are the run line favorite in this matchup. The Tampa Bay Rays have a +1.5 -115 run line at BetRivers PA. The Tampa Bay Rays are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the Houston Astros vs Tampa Bay Rays MLB game on Wednesday, May 21st, 2025?

The Houston Astros are the -150 moneyline favorite at BetMGM and the Tampa Bay Rays are the +148 moneyline underdog at BetRivers.

What is the over-under total line for the Houston Astros vs Tampa Bay Rays MLB game on Wednesday, May 21st, 2025?

The best over line is 8.5 -118 runs at BetMGM, which means you risk $118 to win $100 betting the over. The best under line is 9 -130 runs at BetRivers, and that means you risk $130 to win $100 betting the under.

What is the run line for the Houston Astros vs Tampa Bay Rays MLB game on Wednesday, May 21st, 2025?

The Houston Astros are -1.5 +115 run line favorites at BetMGM, while the Tampa Bay Rays are +1.5 -115 run line underdogs at BetRivers.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Astros
Rays
5/21/25 1:10pm EDT
-150+125
Bet $100 at BetMGM Pennsylvania
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Possible Moneyline Outcomes
  • Tampa Bay Rays bettors risk $100 to win $125 at +125 odds. The implied probability for Tampa Bay Rays is 44.44%.
  • Houston Astros bettors risk $100 to win $66.67 at -150 odds. The implied probability for Houston Astros is 60%.

Houston Astros at Tampa Bay Rays Prop Bets

MLB Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Astros
Rays
First Team to Score
5/21/25 1:10pm EDT
-200+155Bet
Astros
Rays
Tie
1st Inning Winner
5/21/25 1:10pm EDT
+250+375-140Bet
Astros
Rays
Tie
First 3 Innings Winner
5/21/25 1:10pm EDT
+110+185+280Bet
Astros
Rays
To Extra Innings
5/21/25 1:10pm EDT
Yes +775No -1400Bet
BetMGM Sports Betting BetMGM
Astros
Rays
1st Team to Score Will Win
5/21/25 1:10pm EDT
Yes -250No +190Bet
Astros
Total Runs
HOU at TAM
5/21/25 1:10pm EDT
4.5 o -1184.5 u -110Bet
Rays
Total Runs
HOU at TAM
5/21/25 1:10pm EDT
3.5 o -1253.5 u -105Bet
Hunter Brown
Strikeouts Thrown
HOU at TAM
5/21/25 1:10pm EDT
6.5 o -1506.5 u +115Bet
BetMGM Sports Betting BetMGM
Taj Bradley
Strikeouts Thrown
HOU at TAM
5/21/25 1:10pm EDT
5.5 o +1405.5 u -190Bet

Houston Astros & Tampa Bay Rays Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Houston Astros World Series Odds
2025 Houston Astros World Series Odds

Team
BetMGM Sports Betting BetMGM BetRivers Sports Betting BetRivers
Astros
+2500
Bet
+2500
Bet
Tampa Bay Rays World Series Odds
2025 Tampa Bay Rays World Series Odds

Team
BetMGM Sports Betting BetMGM BetRivers Sports Betting BetRivers
Rays
+8000
Bet
+7500
Bet

Houston Astros & Tampa Bay Rays Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - Houston Astros, Tampa Bay Rays
Team W L Pct GB Home Away RS RA Diff Strk L10
Houston Astros27250.519+6.517-1010-15209187+22W15-5
Tampa Bay Rays25260.490+8.015-1810-8199200-1W46-4

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Houston Astros vs Tampa Bay Rays MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, May 21st, 2025 at 1:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the Houston Astros vs Tampa Bay Rays Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Houston Astros vs Tampa Bay Rays Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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