The Padres will play the Giants on Wednesday, May 6th, 2026. Your timezone's first pitch time is 3:45 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Matchup Stats
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - The San Diego Padres have a 97.33 power ranking. The power ranking for the San Francisco Giants is 88.67.
- Visiting San Diego Padres - The San Diego Padres have a 7-3 record as a visiting team, ranking them 3rd Overall for visiting team wins.
- Home San Francisco Giants - The San Francisco Giants have a 4-7 record as a home team. They rank 6th for home team wins in the Overall standings.
- Runs Scored - The San Diego Padres currently stand 16th (97) Overall, with the San Francisco Giants ranking 23rd (78) for runs scored.
- Runs Allowed - The San Diego Padres are 23rd (79) Overall for runs allowed. The San Francisco Giants stand 15th (97) for runs allowed.
- Team Streaks - The San Diego Padres have won their last 3 games. Meanwhile, the San Francisco Giants won their last game.
- Team Records - The San Diego Padres have a 16-7 Overall record (0.0 GB National West Division), with the San Francisco Giants possessing a 10-13 Overall standing (6.0 GB National West Division).
Best Padres at Giants Odds
| Underdog San Francisco Giants | Favorite San Diego Padres |
|---|---|
| Over | Under |
|---|---|
| Underdog San Francisco Giants | Favorite San Diego Padres |
|---|---|
Matchup Odds FAQs
The San Diego Padres are the -115 moneyline favorite at BetMGM and the San Francisco Giants are the -105 moneyline underdog at BetMGM.
The best over line is 8.5 -105 runs at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 8.5 -115 runs at BetMGM, and that means you risk $115 to win $100 betting the under.
The San Diego Padres are -1.5 +145 run line favorites at BetMGM, while the San Francisco Giants are +1.5 -180 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Padres
Giants
5/06/26 3:45pm EDT | -115-105 |
- San Francisco Giants bettors risk $100 to win $95.24 at -105 odds. The implied probability for San Francisco Giants is 51.22%.
- San Diego Padres bettors risk $100 to win $86.96 at -115 odds. The implied probability for San Diego Padres is 53.49%.
San Diego Padres at San Francisco Giants Prop Bets
| BetMGM Bet |
|
|---|---|
Padres
Giants
First Team to Score
5/06/26 3:45pm EDT | -150+115Bet |
Padres
Giants
Tie
1st Inning Winner
5/06/26 3:45pm EDT | +300+270-130Bet |
Padres
Giants
Tie
First 3 Innings Winner
5/06/26 3:45pm EDT | +154+125+300Bet |
Padres
Giants
To Extra Innings
5/06/26 3:45pm EDT | Yes +775No -1400Bet |
| BetMGM | |
Padres
Giants
1st Team to Score Will Win
5/06/26 3:45pm EDT | Yes -250No +190Bet |
Padres
Total Runs
SDG at SFO 5/06/26 3:45pm EDT | 4.5 o +1054.5 u -140Bet |
Giants
Total Runs
SDG at SFO 5/06/26 3:45pm EDT | 3.5 o -1403.5 u +105Bet |
San Diego Padres & San Francisco Giants Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
San Diego Padres World Series Odds|
Team | BetMGM |
|---|---|
| Padres | +4000 Bet |
|
Team | BetMGM |
|---|---|
| Giants | +20000 Bet |
San Diego Padres & San Francisco Giants Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| San Diego Padres | 16 | 7 | 0.696 | 0.0 | 9-4 | 7-3 | 97 | 79 | +18 | W3 | 9-1 |
| San Francisco Giants | 10 | 13 | 0.435 | +6.0 | 4-7 | 6-6 | 78 | 97 | -19 | W1 | 5-5 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Diego Padres vs San Francisco Giants MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, May 6th, 2026 at 3:45 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the San Diego Padres vs San Francisco Giants Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the San Diego Padres vs San Francisco Giants Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other May 6, 2026 MLB Games
- Toronto Blue Jays vs Tampa Bay Rays - 5/06/26 1:10pm EDT
- Milwaukee Brewers vs St. Louis Cardinals - 5/06/26 1:15pm EDT
- Los Angeles Dodgers vs Houston Astros - 5/06/26 2:10pm EDT
- Chicago White Sox vs Los Angeles Angels - 5/06/26 4:07pm EDT
- Atlanta Braves vs Seattle Mariners - 5/06/26 4:10pm EDT
- Oakland Athletics vs Philadelphia Phillies - 5/06/26 6:40pm EDT
- Baltimore Orioles vs Miami Marlins - 5/06/26 6:40pm EDT
- Boston Red Sox vs Detroit Tigers - 5/06/26 6:40pm EDT
- Minnesota Twins vs Washington Nationals - 5/06/26 6:45pm EDT
- Texas Rangers vs New York Yankees - 5/06/26 7:05pm EDT
- Cincinnati Reds vs Chicago Cubs - 5/06/26 7:40pm EDT
- Cleveland Guardians vs Kansas City Royals - 5/06/26 7:40pm EDT
- New York Mets vs Colorado Rockies - 5/06/26 9:20pm EDT
- Pittsburgh Pirates vs Arizona Diamondbacks - 5/06/26 9:40pm EDT