The Padres will play the Giants on Thursday, June 5th, 2025. Your timezone's first pitch time is 3:45 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - As the 2025 season continues, the San Diego Padres possess a 95.00 SportsBetting3.com power ranking. The San Francisco Giants now have a 95.33 power ranking. Teams with a higher SportsBetting3.com power ranking will typically be moneyline favorites.
- Visiting San Diego Padres - The San Diego Padres head into this matchup with a 13-14 record as a visiting team. This standing ranks them 5th Overall for visiting team wins.
- Home San Francisco Giants - The San Francisco Giants will throw the first pitch possessing a 17-9 home team record. That puts them 4th for home team wins in the Overall MLB standings.
- Runs Scored - San Diego Padres batters have produced 217 runs, ranking them 18th Overall, with the San Francisco Giants ranking 10th (239) for runs scored.
- Runs Allowed - San Diego Padres pitchers and fielders have allowed 199 runs, ranking them 22nd Overall for runs allowed. Meanwhile, the San Francisco Giants now rank 22nd Overall, allowing 199 runs.
- Team Streaks - The San Diego Padres have won their last 2 games. Their opponent, the San Francisco Giants have lost their last 2 games.
- Team Records - Let's review each team's records. The San Diego Padres have a 30-22 Overall record (2.0 GB National West Division), with the San Francisco Giants notching a 31-24 Overall standing (3.0 GB National West Division).
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye! The Padres be facing the Giants on Thursday!
San Diego be needin' to turn things around after a poor run...
The Giants be no easy foe with a better overall record...
Ye can expect a fierce battle on the diamond this day...
Check out this game's prop bets below and bet on MLB baseball at legal US sportsbooks. Review each team's standing at the bottom of the page.
Best Padres at Giants Odds
| Underdog San Diego Padres | Favorite San Francisco Giants |
|---|---|
| Over | Under |
|---|---|
| Underdog San Francisco Giants | Favorite San Diego Padres |
|---|---|
Matchup Odds FAQs
The San Francisco Giants are the -115 moneyline favorite at BetMGM and the San Diego Padres are the -105 moneyline underdog at BetMGM.
The best over line is 7.5 +105 runs at BetMGM, which means you risk $100 to win $105 betting the over. The best under line is 7.5 -125 runs at BetMGM, and that means you risk $125 to win $100 betting the under.
The San Diego Padres are -1.5 +165 run line favorites at BetMGM, while the San Francisco Giants are +1.5 -200 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Padres
Giants
6/05/25 3:45pm EDT | -105-115 |
- San Diego Padres bettors risk $100 to win $95.24 at -105 odds. The implied probability for San Diego Padres is 51.22%.
- San Francisco Giants bettors risk $100 to win $86.96 at -115 odds. The implied probability for San Francisco Giants is 53.49%.
San Diego Padres at San Francisco Giants Prop Bets
| BetMGM Bet |
|
|---|---|
Padres
Giants
First Team to Score
6/05/25 3:45pm EDT | -150+115Bet |
Padres
Giants
Tie
1st Inning Winner
6/05/25 3:45pm EDT | +325+333-160Bet |
Padres
Giants
Tie
First 3 Innings Winner
6/05/25 3:45pm EDT | +154+150+240Bet |
Padres
Giants
To Extra Innings
6/05/25 3:45pm EDT | Yes +675No -1100Bet |
| BetMGM | |
Padres
Giants
1st Team to Score Will Win
6/05/25 3:45pm EDT | Yes -250No +190Bet |
Padres
Total Runs
SDG at SFO 6/05/25 3:45pm EDT | 3.5 o -1183.5 u -110Bet |
Giants
Total Runs
SDG at SFO 6/05/25 3:45pm EDT | 3.5 o -1103.5 u -118Bet |
Dylan Cease
Strikeouts Thrown
SDG at SFO 6/05/25 3:45pm EDT | 6.5 o +1006.5 u -130Bet |
| BetMGM | |
Robbie Ray
Strikeouts Thrown
SDG at SFO 6/05/25 3:45pm EDT | 5.5 o -1505.5 u +115Bet |
San Diego Padres & San Francisco Giants Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
San Diego Padres World Series Odds|
Team | BetMGM |
|---|---|
| Padres | +2500 Bet |
|
Team | BetMGM |
|---|---|
| Giants | +3500 Bet |
San Diego Padres & San Francisco Giants Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| San Diego Padres | 30 | 22 | 0.577 | +4.0 | 17-8 | 13-14 | 217 | 199 | +18 | W2 | 3-7 |
| San Francisco Giants | 31 | 24 | 0.564 | +4.5 | 17-9 | 14-15 | 239 | 199 | +40 | L2 | 5-5 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Diego Padres vs San Francisco Giants MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Thursday, June 5th, 2025 at 3:45 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the San Diego Padres vs San Francisco Giants Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the San Diego Padres vs San Francisco Giants Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other June 5, 2025 MLB Games
- Arizona Diamondbacks vs Atlanta Braves - 6/05/25 12:15pm EDT
- Detroit Tigers vs Chicago White Sox - 6/05/25 2:10pm EDT
- Philadelphia Phillies vs Toronto Blue Jays - 6/05/25 3:07pm EDT
- Minnesota Twins vs Oakland Athletics - 6/05/25 3:35pm EDT
- Baltimore Orioles vs Seattle Mariners - 6/05/25 3:40pm EDT
- New York Mets vs Los Angeles Dodgers - 6/05/25 4:10pm EDT
- Chicago Cubs vs Washington Nationals - 6/05/25 6:45pm EDT
- Cleveland Guardians vs New York Yankees - 6/05/25 7:05pm EDT
- Texas Rangers vs Tampa Bay Rays - 6/05/25 7:35pm EDT
- Kansas City Royals vs St. Louis Cardinals - 6/05/25 7:45pm EDT
- Houston Astros vs Pittsburgh Pirates - 6/05/25 8:45pm EDT